Alright, so I started taking Zoloft on Tuesday night (3 nights in a row now) and the first day after my first dose I feel AMAZING. Not sure why because I was told it will take 1-2 weeks for me to feel anything, but anywho, I felt ontop of the World. Yesterday/last night my anxiety came back in full force out of nowhere. I was resentful towards my fiancé, my mind would NOT stop racing, and I couldn't sleep. I woke up this morning gently shaking and again, my mind would NOT stop racing. I've read a few posts saying that it's normal for it to get worse before it gets better and I'm just hoping someone can put some truth into that for me! I'm going to stick it out regardless but I'm hoping that it will pass soon.
From the literature regarding Zoloft:
"Common (1% to 10% of users): Affect/emotional lability, aggravated depression, aggression, agitation, anxiety, bruxism/teeth grinding, depression, nervousness"
"Side effects have been reported to be generally mild and transient. They are most common during the first 2 weeks of treatment and decrease in intensity and frequency with continued treatment. They generally do not lead to treatment cessation."
"Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood, anxiety, and lack of interest in activities may need up to 6-8 weeks to fully improve.
Sertraline (Zoloft) | NAMI: National Alliance on Mental Illness"
So you see these are common side effects for some people when starting treatment with an antidepressant/anxiolytic. Your initial reaction is what is called the placebo effect as it takes time for the medication to reach therapeutic levels in your blood/brain.
Glad to hear you're determined to stick with it... you'll be feeling much better soon... and Zoloft is rated amongst the top three medications for depression/anxiety by user reviews.
Best regards... and if you have any other specific questions or concerns please feel free to post again anytime!
Wildcat vet is 100% correct. For me the first two or three weeks were the roughest. So give it some time to work and you should start feeling better and better. It takes a good 6 weeks to reach full therapeutic levels. I know it's hard but hang in there. Best of luck and remember we are always here if you need to talk.
I’ve been taking Zoloft for 3 months almost. I started at 25mg & did feel better within a week. I then increased to 37.5mg and could not stay awake, I had that dose a month. Because I’m so sensitive to meds my doc has me at only 25mg which isn’t even a therapeutic dose for most people. My depression is 50% better . I’ve tried many ssri’s & snris this is the only one that has done anything. As the others have said, give it some more time & hopefully your side effect will get better. I’m even sleepy on 25mg & use my Adderall not only for my adhd but to stay awake!
- Zoloft Information for Consumers
- Zoloft Information for Healthcare Professionals (includes dosage details)
- Side Effects of Zoloft (detailed)
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Updated 18 Mar 2019 • 5 answers
Updated 17 Jan 2017 • 1 answer
Updated 6 May 2018 • 1 answer
Updated 24 Aug 2018 • 1 answer
Updated 20 Feb 2019 • 1 answer