26 year old female - I am confused because I have high levels of IgG protein in my blood (1843)... Gamma Globulin (1.7), M-spike (0.7). I was tested for multiple myeloma (bone marrow biopsy and full body bone scan) because of the above symptoms (bone pain and IgG, and m-spike). The m-spike is supposed to indicate myeloma but the full body x-ray scan showed no lesions or fractures. I don't understand why I would have something that indicates cancer, but yet nothing has been found. Should we look at something else? I know that most of my symptoms are related to iron deficiency anemia but I am still concerned about what is showing up in my blood work.
I lived in the states for a long time, now I do not... the country I live in now, one goes to the doctor, then get your orders for the exams, once you have the exams you make an appoinmet with the same doctor and he/she will explain to you your test readings. Luckily I am a very healthy person, and was never ordered any kind of test ( or see a doc). I do not know how the system works in the US, but they can not just give you the results and not have them explained to you, you are not a doctor.
By the way in your question, you never mention anything about going to the doctor to have your readings explained to you... just wanted to clarify that point.- You say you know it is because of iron deficiency and that is all.-
In multiple myeloma, there are immunoglobin light chains in additon to full Immunoglobin molecules
There is a condition called Lymphoplasmocytic Lymphoma that secretes only Ig M as u said and does not produce characterstic bone findings of Multiple Myeloma.
In addition it produces anemia, blurring of vision etc.
I think u suffer from this disease.
Consult your doctor.
Another condition called Solitary myeloma involves only one site and not the whole body. Most often it involves bones but may involve lungs, oronasopharynx and nasal sinuses or other soft tissues. Must take these into consideration as these can be corrected by local resection.
Thanks for ur responses... I have an appt with internal medicine dr on Thursday. I will mention all this to him... there are so many possible conditions but yet I am the only person I know that has been jumping through hoops just to know what is wrong with me. I aso heard that it could be crohns disease or hepatitis... hopefully the internal med dr will do mire than my hematologist. Thanks.
I have had multiple myeloma since 2004 -- in full remission. The first bone marrow biopsy I had showed no sign of the myeloma. Have you done the 24-hour urine collection? In that they look for specific light chains that indicate myeloma. Just from experience and advice from many oncologists, a bone scan is fairly useless in myeloma. A metastatic skeletal survey (full body x-ray) picks up osteolytic lesions better than any other test. From the myeloma and chemo/radiation, my immune system no longer works (hypogammaglobulinemia) and so receive a weekly infusion of IgG and will for the rest of my life. Myeloma is very elusive and usually not found until a lesion develops. You will know without a doubt if you develop one. Just keep pushing the doctors to find the reason for the anomalies in your blood work. Hope this helps.
Thanks so much for the comments. I haven't been on here for a while... I've given up hope until something solid is certain is found out. After the bone x-rays which showed nothing. I also had the bone marrow biopsy but the only thing that showed was the absent iron stores. Everything else was okay... I mean everything. Which of course left the dr's confused again. It's been almost 3 years and still no diagnosis and the last time we checked my spike (almost a year ago) it had gone done one point. I know that something is wrong; I have a wide range of internal symptoms and swollen nodes but to this day and after test after test after test, still nothing. I really thank you all for the help and wish you all the best.
I had very similar blood work which indicated Myeloma but the doctors would not confirm the diagnosis until the bone marrow biopsy. My e ray and CTC scans didn´t show any lesions or fractures of significance but the bone marrow biopsy showed myeloma cells which confirmed the diagnosis.
I think it could be a good idea to go back and explain your concerns and ask the direct question Do I have myeloma? Even if the diagnosis is that you do many people are stable and do not require treatment for many years . in my case I lived quite happily for five years before my doctor decided to start any treatment. - I have now had treatment and am doing really well, in fact I have recently started riding my horse again.
Remember also that even if you do have Myeloma new drugs are coming along all the time and the outlook for Myeloma patients has improved dramatically during the last few years.
Good Luck with everything
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