... switched me to Effexor by slowly decreasing the zoloft while simultaneously slowly stepping into Effexor. Just went from the 37.5 to 75 mg. Effexor and my depression is worse than ever. She told me I would definitely need a higher dose, since I was on the max zoloft. I don't know how long I can handle this horrible feeling. My anxiety is through the roof, and I feel hopeless. I have combat PTSD, major depression and generalized anxiety disorder