... now locked in the safe) but while he was on it, his mood and anxiety was so good. Can 16 year old be prescribed Lyrica?
I'm copying this from a Doctor's Internet post:
Pregabalin is a gamma-aminobutyric acid analog that is approved by the US Food and Drug Administration (FDA) for the treatment of pain associated with diabetic neuropathy, postherpetic neuralgia, fibromyalgia, and neuropathic pain associated with spinal cord injury. In addition, it is approved as adjunctive therapy for adults with partial-onset seizures. Pregabalin is a Schedule V medication in the United States. Although pregabalin has not been FDA-approved for general anxiety disorder (GAD), there is evidence to support its use as monotherapy and adjunctive therapy, and it is considered to be a first-line treatment by the World Federation of Societies of Biological Psychiatry.
Generalized anxiety is one of the most common psychiatric disorders, with a lifetime prevalence of 4%-7%. Patients with GAD experience exaggerated worry and tension accompanied by several somatic physical symptoms, such as headache, gastrointestinal symptoms, insomnia, and pain. Patients with GAD often worry about multiple situations, including money, health, family, work, or other life issues. GAD is diagnosed when a person worries excessively about a variety of everyday problems for at least 6 months. The mainstays for the pharmacologic treatment of GAD include selective serotonin reuptake inhibitors (SSRIs), serotonin/norepinephrine reuptake inhibitors (SNRIs), buspirone, tricyclic antidepressants, and benzodiazepines.
Although antidepressants and buspirone effectively treat GAD, it may take 4-6 weeks for symptom relief to occur. In general, patients with GAD desire relief as soon as possible. Benzodiazepines have a rapid onset of action and work quickly to relieve physiologic symptoms of anxiety. However, benzodiazepines are not ideal drugs in most patients because of adverse effects, drug interactions, and risk for dependence and addiction. In addition, benzodiazepines do not treat depression or other anxiety disorders, which commonly co-occur with GAD. Benzodiazepines are most appropriate when used during the first 2 weeks of antidepressant use and then discontinued as the antidepressant begins working. Benzodiazepines should be avoided in patients with a history of substance abuse.
Pregabalin works by binding to the alpha-2-delta subunit of N-type voltage-gated calcium channels in the central nervous system. Pregabalin decreases presynaptic calcium currents, thus decreasing the release of several excitatory neurotransmitters that play an important role in anxiety.
Pregabalin was found to be effective for the treatment of GAD in 8 published trials and 1 meta-analysis.[3-11] Several studies used active controls, including alprazolam, lorazepam, and venlafaxine. Although the benefit of pregabalin compared with placebo was demonstrated, the trials with active controls were not designed or powered to detect differences. Overall, patients treated with pregabalin experienced significant decreases in the Hamilton Anxiety Rating Scale (HAM-A) from baseline compared with placebo. Significant benefits on anxiety symptoms were seen as early as 1 week after initiation. Pregabalin was well tolerated; the most common adverse effects were somnolence, dizziness, dry mouth, and headache.
A recent trial examined the dose/response relationship of pregabalin for the treatment of GAD. Overall, maximal reduction in anxiety symptoms occurred at a dose of about 450 mg/day, with a small reduction in treatment effect beyond this dose. There appears to be a different dose/response curve for somatic and psychic anxiety symptoms. Somatic symptoms may respond better to doses close to 600 mg/day, whereas psychic anxiety symptoms may respond to doses around 400 mg/day.
Preliminary evidence suggests that pregabalin is effective for treating GAD in older adults. Elderly patients had a significant improvement in HAM-A scores from baseline compared with patients treated with placebo, similar to that found in trials with younger adults. However, the therapeutic onset was not seen for more than 2 weeks in elderly persons. Although adverse effects were similar to those in the younger population, 3 serious adverse effects occurred that were attributed to pregabalin: increased anxiety, somnolence, and a fracture secondary to a fall.
One study evaluated the long-term efficacy of pregabalin for preventing relapse. A fixed daily dose of pregabalin 450 mg was significantly more effective than placebo for preventing relapse over 6 months in patients with chronic GAD who initially responded to 8 weeks of acute treatment. The investigators also found that dependence and withdrawal were not significantly different from placebo over the 32-week treatment period. However, package labeling for pregabalin recommends that dosing be tapered over 1 week when the medication is discontinued.
Overall, pregabalin seems to be effective for the treatment of GAD, with the best response occurring at 450 mg/day. Pregabalin is well tolerated, but adverse effects of dizziness and somnolence should be monitored in elderly patients. Pregabalin is not FDA-approved for the treatment of GAD, but it is recognized as a valuable treatment option in clinical guidelines. It relieves anxiety within days, which confers an advantage over first-line therapies for SSRIs and SNRIs. Pregabalin seems to have little risk for dependence or withdrawal upon discontinuation of use, which are key advantages over benzodiazepine therapy.
twistedtime; Yes please make an appointment with the doctor and you must be very honest that he was taking some of yours and started to feel better and see if the doctor well orders it due to the black box warning which they well go over it with you. So at least you know the problem is worse than you were thinking but if nothing else the doctor may give him something very close to Lyrica. But at his age and knowing what he is going through now is the time to get all the help you can for your son. Be it some medication along with some type of therapy that they can help him learn what to do when the overwhelming feelings of anxiety pop up. So best to get him into the doctor he knows or looks for a pediatric psychiatrist. good luck Chuck1957
I went on Lyrica after being in pain for 30 years with severe fibromyalgia and anxiety pain, I am still taking Xanax, and Tramadol I quit the Gabapentin. I started the Lyrica and overnight it was like black and white, day and night a miracle the pain anxiety the anxiousness went away. I ask my doctor why this wasn't given to me 30 years ago 20 years ago 10 years ago because I was suffering so much with pain and flares and crying and feeling like I was going to die and hoping that I would not that I wanted to. But that Lyrica for me was a miracle med. My doctor did not have any words for me why I suffered so much. I had to go to 15 doctors rheumatologist, neurologist Etc. and they would not help me until I said could you prescribe me Lyrica?and he did. I am in a different world now. Thank you
- Lyrica Information for Consumers
- Lyrica Information for Healthcare Professionals (includes dosage details)
- Side Effects of Lyrica (detailed)
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