... I have been on it for 5 weeks now. My doctor added Latuda to it 3 weeks ago. I am having a lot of irritability. I am thinking this is coming from the Latuda. Would it be a good idea to go off the Latuda and continue on the 112.5 of Effexor for a few more weeks? I have been going through this for two years and on multiple medicines that haven’t worked. I haven’t been in any of them for the 6-8 weeks and I work with a psychiatrist. If I was at the 150 of Effexor for four weeks and dropped down to 112.5, will it still take 6-8 weeks for the decreased dose to work?