Ive been on 100 mg of Zoloft for abut the last 4 months. I started on 25 mg, then it went to 50 mg then 100 mg. I felt great with the 100 mg then all the sudden last week it feels like it quit working. I have had a big increase of stress in my life so Im not sure if thats it or not. Has anyone seen a big change in 100 to 200 mg or a friend of mine even suggested to talk to my doctor about adding another prescription with it