2. Are osmotic diuretics used for the treatment of hypertension?
3. Oral hypoglycemic agents such as metformine and glibenclamide are administered best
a) Before meal in the morning
b) Before meal at mid day
c) Before meal in the evening
d) After meal in the morning
e) After meal at mid day
f) After meal in the evening
4 More than 3 inhalations of salbutamole should not be required with in 24hr. why?
5 We don’t undertake strenuous exercise while taking Norfloxacin. Why?
6 Is there an interaction between co-artem and
If there is, is it harmful or useful interaction?
7 How does amitriptillin used for diabetic neuropaty?
8 What is the difference between omeprazole and cimetidin, omeprazole and antiacid, cimetidin and antiacid with respect to their clinical indication?
1. Why ACEIs are best among Antihypertensive drugs while there is diabetes mellitus concomitantly?
- 14 Sep 2012 by mastewal abebaw
- 14 September 2012
- diabetes mellitus, diabetes, type 2, hypertension
I can help with a few of these-hopefully some of our pharmacists can chime in and will help more. If I remember right ACE inhibitors are used because they are more sparing of the kidneys than some of the others and protecting kidney function is vital in diabetics because diabetes in itself can destroy kidney function. Osmotic diuretics are not typically used for hypertension-they can actually aggravate HTN. Loop and thiazide diuretics are indicated for HTN. Oral hypoglycemics should be given before meals. Usually they are started out before breakfast or before dinner (with metformin), if that doesnt do it then a dose is added before evening meal (or morning meal if evening meal is started first). Very rarely have I seen them given TID or with the noon meal. Strenuous exercise and fluoroquinalones like Norfloxacin do not mix becuse of the possibility of tendon rupture is increased while taking fluorquinalones-any pain, inflammation or tendon issues should be reported and followed by the physician immediately until tendon rupture is ruled out. As for amitriptyline in diabetic neuropathy-The TCAs are widely used to treat chronic pain states,
including low back pain and other types of neuropathic
pain. Their analgesic effect is independent of their antidepressant
effect and, like the SNRIs, is thought to be
related to inhibition of serotonin and norepinephrine
reuptake, leading to more of these neurotransmitters
available in the synapse. Despite their widespread use,
none of the TCAs has been approved by the FDA for
treatment of DPNP or any type of pain.
Omeprazole is a proton pump inhibitor and cimetidine is a H2 receptor antagonist.
Omeprazole inhibits activity of acid (proton) pump and binds to hydrogen-potassium adenosine triphosphatase at secretory surface of gastric parietal cells to block formation of acid. Cimetidine competitively inhibits action of histamine on the H2 receptor sites of parietal cells, decreasing acid secretion. Hopefully that answers some of your homework but there a still a couple of questions I didnt answer. You need to look those up or we have a pharmacist who comes on pretty regular and perhaps she can answer more.
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