Generic Name: glyburide (GLYE bue ride)
Brand Name: DiaBeta, Glynase PresTab, Micronase
What is glyburide?
Glyburide is used to treat type 2 diabetes.
Glyburide is not for treating type 1 diabetes.
You should not use Glyburide if you are being treated with bosentan (Tracleer), or if you have diabetic ketoacidosis (call your doctor for treatment).
Before taking glyburide, tell your doctor if you are allergic to sulfa drugs, if you have been using insulin or chlorpropamide (Diabinese), or if you have hemolytic anemia (a lack of red blood cells), an enzyme deficiency (G6PD), a nerve disorder, liver disease, or kidney disease.
Take care not to let your blood sugar get too low. Low blood sugar (hypoglycemia) can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency.
Before taking this medicine
You should not use glyburide if you are allergic to it, or:
if you are being treated with bosentan (Tracleer);
if you have type 1 diabetes; or
if you have diabetic ketoacidosis (call your doctor for treatment with insulin).
To make sure this medicine is safe for you, tell your doctor if you have:
hemolytic anemia (a lack of red blood cells);
an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);
a nerve disorder affecting bodily functions;
liver or kidney disease; or
an allergy to sulfa drugs.
Before taking glyburide, tell your doctor if you have taken chlorpropamide or used insulin during the past 2 weeks.
Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of taking this medicine.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Follow your doctor's instructions about taking glyburide if you are pregnant or breast-feeding a baby. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester of pregnancy. Your dose needs may also be different while you are breast-feeding. Your doctor may want you to use insulin while you are pregnant or breast-feeding.
It is not known whether glyburide passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
How should I take glyburide?
Take glyburide exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Take glyburide with your first meal of the day, unless your doctor tells you otherwise.
Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.
Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, and feeling anxious or shaky. To quickly treat low blood sugar, always keep a fast-acting source of sugar with you such as fruit juice, hard candy, crackers, raisins, or non-diet soda.
Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency.
Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination, blurred vision, headache, and tiredness.
Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.
If your doctor changes your brand, strength, or type of glyburide, your dosage needs may change. Ask your pharmacist if you have any questions about the new kind if medicine you receive at the pharmacy.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
Glyburide dosing information
Usual Adult Dose for Diabetes Type 2:
-Initial dose: 2.5 mg to 5 mg orally once a day
-Dose titration: Increase in increments of no more than 2.5 mg at weekly intervals based upon blood glucose response
-Maintenance dose: 1.25 mg to 20 mg orally as a single dose or in divided doses
-Maximum dose: 20 mg/day
-Initial dose: 1.5 mg to 3 mg orally once a day
-Dose titration: Increase in increments of no more than 1.5 mg at weekly intervals based upon blood glucose response
-Maintenance dose: 0.75 mg to 12 mg orally as a single dose or in divided doses
-Maximum dose: 12 mg/day
-Administer with breakfast or the first main meal of the day
-Lower initial doses may be used in patients who are sensitive to hypoglycemic drugs
-Once a day therapy is generally satisfactory, however, some patients may have a more satisfactory response with twice-a-day dosing, especially those receiving higher doses.
TRANSFER FROM OTHER HYPOGLYCEMIC THERAPY:
-Oral Antidiabetic Therapy: No exact dosage relationships exists between standard glyburide, micronized glyburide, or other oral hypoglycemic agents; when transferring patients from other oral hypoglycemic therapy, the maximum starting doses should be observed.
--If the insulin dose is less than 20 units per day substitute 2.5 mg to 5 mg (standard) OR 1.5 mg to 3 mg (micronized) orally once a day.
--If the insulin dose is between 20 and 40 units per day, substitute 5 mg (standard) OR 3 mg (micronized) orally once a day.
--If the insulin dose is more than 40 units per day; transition the patient by concomitantly decreasing insulin by 50% and starting glyburide at 5 mg (standard) OR 3 mg (micronized) orally once a day; as insulin is progressively withdrawn, titrate the dose in increments of 1.25 mg to 2.5 mg (standard) OR 0.75 mg to 1.5 mg (micronized) orally once a day every 2 to 10 days.
Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Usual Geriatric Dose for Diabetes Type 2:
Initial dose: 1.25 mg to 2.5 mg (standard) orally or 0.75 mg to 1.5 mg (micronized) orally once a day.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A glyburide overdose can cause life-threatening hypoglycemia.
Symptoms of severe hypoglycemia include extreme weakness, confusion, tremors, sweating, fast heart rate, trouble speaking, nausea, vomiting, rapid breathing, fainting, and seizure (convulsions).
What should I avoid while taking glyburide?
If you also take colesevelam, avoid taking it within 4 hours after you take glyburide.
Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.
Avoid exposure to sunlight or tanning beds. Glyburide can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Glyburide side effects
Get emergency medical help if you have signs of an allergic reaction to glyburide: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using glyburide and call your doctor at once if you have:
sudden weakness or ill feeling, fever, chills, sore throat,
mouth sores, red or swollen gums, easy bruising or bleeding;
low levels of sodium in the body - headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady;
liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
severe skin reaction - fever, swelling in your face or tongue, burning in your eyes, skin pain, red or purple skin rash that spreads (especially in the face or upper body), itching, blisters, breakdown of the outer layer of skin.
Older adults may be more likely to have low blood sugar while taking glyburide.
Common glyburide side effects may include:
nausea, upset stomach, heartburn, feeling full;
muscle or joint pain;
blurred vision; or
mild rash or skin redness.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect glyburide?
Many other medicines can affect your blood sugar, and some medicines can increase or decrease the effects of glyburide. Some drugs can also cause you to have fewer symptoms of hypoglycemia, making it harder to tell when your blood sugar is low. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products.
More about glyburide
Other glyburide documents
Where can I get more information?
- Your pharmacist can provide more information about glyburide.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use glyburide only for the indication prescribed.
- Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2017 Cerner Multum, Inc. Version: 11.01.
Date modified: October 05, 2017
Last reviewed: August 22, 2017