Generic Name: azacitidine (ay za SYE ti deen)
Brand Names: Vidaza

What is Vidaza?

Vidaza (azacitidine) is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Vidaza is used to treat certain types of bone marrow cancers and blood cell disorders.

Vidaza may also be used for purposes not listed in this medication guide.

Important information

Vidaza is a cancer medication used to treat certain types of bone marrow cancers and blood cell disorders.

You should not receive this medication if you have liver cancer.

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Vidaza can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).

Before receiving Vidaza

You should not receive Vidaza if you are allergic to azacitidine or mannitol, or if you have liver cancer.

To make sure Vidaza is safe for you, tell your doctor if you have:

  • kidney disease; or

  • liver disease, or a history of liver cancer.

FDA pregnancy category D. Do not use Vidaza if you are pregnant. It could harm the unborn baby.

See also: Pregnancy and breastfeeding warnings (in more detail)

Use birth control to prevent pregnancy while you are receiving Vidaza, whether you are a man or a woman. If a man fathers a baby while using Vidaza, the baby may have birth defects. Use a condom to prevent pregnancy during your treatment, and for at least 4 weeks after your treatment ends.

It is not known whether azacitidine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How is Vidaza given?

Vidaza is injected into a vein through an IV. A healthcare provider will give you this injection.

This medication is usually given for 7 days in a row every 4 weeks for at least 4 treatment cycles. Your treatment schedule may be different. Follow your doctor's instructions.

You may also be given medications to reduce nausea and vomiting while you are receiving Vidaza.

Tell your caregiver right away if this medication accidentally gets on your skin. Wash the area thoroughly with soap and warm water.

Vidaza can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Vidaza injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid?

Azacitidine can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Patients and caregivers should wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Body fluids should not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Do not receive a "live" vaccine while using Vidaza, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Vidaza side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Vidaza: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • pale skin, feeling light-headed or short of breath, easy bruising, unusual bleeding;

  • fever, chills, body aches, flu symptoms, sores in your mouth and throat;

  • redness, swelling, warmth, oozing, or other signs of skin infection;

  • sudden chest pain or discomfort, wheezing, dry cough or hack;

  • severe ongoing nausea, vomiting, or diarrhea;

  • burning or skin changes where the injection was given;

  • lower back pain, blood in your urine, little or no urinating;

  • numbness or tingly feeling around your mouth;

  • muscle weakness, tightness, or contraction, overactive reflexes;

  • fast or slow heart rate, weak pulse, confusion, fainting; or

  • low potassium (extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling).

Common Vidaza side effects may include:

  • mild nausea, vomiting, loss of appetite;

  • stomach pain, diarrhea, constipation;

  • feeling weak or tired;

  • pain, redness, bruising, or other irritation where the injection was given;

  • headache, dizziness, anxiety;

  • joint or muscle pain; or

  • cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Vidaza?

Other drugs may interact with Vidaza, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about Vidaza.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Vidaza only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 6.02. Revision Date: 2013-07-01, 11:51:53 AM.

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