Zilmax Medicated Premix (Canada)

Manufacturer: Intervet/Schering-Plough

Zilpaterol Hydrochloride 4.8% W/w

DIN 02324121

For Veterinary Use Only

TO BE USED ONLY IN CATTLE WEIGHING OVER 450 KG AND FED IN CONFINEMENT FOR SLAUGHTER

Warnings

Treated animals must not be slaughtered for use in food for at least four (4) days after the latest treatment with this drug. Do not use in calves to be processed for veal. Not for use in humans. Keep out of reach of children.

Active Ingredient

Contains zilpaterol hydrochloride, 48 grams per kilogram

Zilmax Medicated Premix Indications

For increased carcass leanness, increased dressing percent, improved rate of body weight gain and improved feed efficiency in cattle fed in confinement for slaughter during the last 20 to 40 days on feed.

In clinical trials performed at various locations in North America, the following effects were demonstrated:

Nc

Carcass Effects	Effect of Zilpaterola
Dressing Percentage, %	↑
Hot Carcass Weight, (kg)	↑
Ribeye Area, (cm2)	↑
Yield Grade	↓b
12th Rib Fat Thickness, (cm)
Marbling Score	Nc When Fed For 20 Days

^a The effect of zilpaterol on parameters listed in this table is supported by data generated at the dose tested in the clinical efficacy trials. NC = No Change, ↑ = increased, ↓ = decreased

^b Reduction indicates an improvement in Yield Grade

Zilmax Medicated Premix Dosage And Administration

For use in Manufactured Feeds Only. Do not feed undiluted. Zilmax^® must be thoroughly mixed into feeds before use.

The recommended inclusion rate in complete feed for cattle fed in confinement is 8.3 g zilpaterol hydrochloride per tonne (8.3 ppm) on a 100% dry matter basis. The amount of zilpaterol hydrochloride consumed daily by cattle fed in confinement for slaughter will depend upon the consumption rate of the medicated feed. Zilpaterol hydrochloride consumption will range between 60 and 90 mg per head per day based on the consumption rates in the table below:

Cattle Weight (kg)	Average Feed Consumption1/Head/Day, 100% Dry Matter (kg)	Zilpaterol Hydrochloride Consumed Daily by each Animal (mg)
450	7.65	63.50
500	9.00	74.70
550	10.45	86.74
600	12.00	99.60

¹ assumes ad libitum intake

Mixing Directions: It is recommended that Zilmax^® be diluted in a suitable carrier before addition to the final feed. A dilution of 1 part Zilmax^® and 9 parts carrier is the suggested working premix. No medicated Feed should be manufactured with less than 8.3 grams zilpaterol hydrochloride/tonne on a 100% dry matter basis. Zilmax^® and working premix addition rates for complete feeds of varying dry matter are in the following table:

Complete Feed % Dry Matter	Zilpaterol Hydrochloride Level (g/tonne)	kg to Be Added Per Tonne of Feed
		Zilmax®	1-9 Working Premix
60	5.0	0.104	1.04
70	5.8	0.121	1.21
80	6.7	0.140	1.40
90	7.5	0.156	1.56
100	8.3	0.173	1.73

Thoroughly mix both working premix and finished feed to ensure complete and uniform distribution of the Zilmax^®.

Feeding Directions: Complete feed for cattle fed in confinement for slaughter must be fed continuously at a rate of 8.3 g zilpaterol hydrochloride/tonne on a 100% dry matter basis for a period of not less than 20 consecutive days nor more than 40 consecutive days at the end of the feeding period.

Liquid Supplements Intended For Addition To Dry Feeds For Confinement Cattle

● Liquid Supplements should be in a pH range of 3.8 to 7.5

● Liquid Supplements should be recirculated or agitated daily and prior to use for 10 to 20 minutes

● Liquid Supplements can be manufactured containing 83 to 830 g zilpaterol hydrochloride/tonne.

Before feeding, the medicated Liquid supplement must be thoroughly mixed with other feed materials to make a complete feed. Examples of addition rates to complete feeds are shown in the following table:

Zilpaterol Hydrochloride in Liquid Supplements (g/tonne)	Addition Rate of Liquid Supplement to Complete Feed, 100% Dry Matter (kg/tonne)	Zilpaterol Hydrochloride in Final Complete Feed, 100% Dry Matter (g/tonne)*
83	100	8.3
415	20	8.3
830	10	8.3

* The dry matter content of the complete feed will be reduced proportional to the amount of liquid supplement added to the feed.

Zilmax Medicated Premix Cautions

Not for animals intended for breeding. Do not allow horses or other equines access to feed containing Zilmax^®. Animals receiving Zilmax^® may exhibit an increased respiratory rate as well as elevated levels of creatine phosphokinase (CPK) and creatinine.

Handler Safety Warnings

The active ingredient in Zilmax^®, is zilpaterol hydrochloride a beta₂-adrenergic agonist. Not for use in humans. Individuals with cardiovascular disease should exercise special caution to avoid exposure to this medicated feed. An anti-dust process has been applied in order to greatly reduce inhalation risk. Extended handling tasks with the potential for dust generation requires respiratory protection. Wear appropriate skin protection (e.g., impervious gloves, apron, overalls) if there is potential for extended skin contact. Wear protective eye wear, if there is a potential for eye contact. If accidental eye contact occurs, immediately rinse with water and consult a physician. Operators should wash thoroughly with soap and water after handling.

Storage

Store between 15 to 25°C.

Intervet Canada Corp., 16750, route Transcanadienne, Kirkland QC, H9H 4M7

1 888 306-0069

Canadian Patent #: CA2178783

Net Weight:
10 kg	024558.01.0000.570 09-0045PCH

Nac No.

12082130