Zentonil (Canada)

S-Adenosylmethionine

ENTERIC-COATED TABLETS FOR CATS AND DOGS

Sold Only Through Veterinarians

What Is Zentonil?

ZENTONIL is a nutritional supplement. It is a newly available form of S-Adenosylmethionine intended for dogs and cats with liver problems.

How Does It Work?

The active ingredient in ZENTONIL, S-adenosylmethionine, is used by the liver in many biochemical pathways. It helps in strengthening cell membranes, improving liver cell function, detoxifying destructive metabolic by-products and providing the building blocks for antioxidants used by the liver.

How Can It Help My Pet?

ZENTONIL will in many cases help reduce the evidence of liver damage. It helps prevent the build up of free radicals in the liver by boosting glutathione levels in dogs and cats, protects liver cells from toxins and death and helps repair and heal already damaged liver cells.

How Long Will It Take Before I See Some Improvement?

Depending on the actual liver condition, evidence of benefits may be noted within 30 days. Studies have shown that peak values are in the body's circulation within 1 to 2 hours following administration. The beneficial effects take longer to manifest themselves due to the complex chemical reactions that occur in the liver.

How Long Will My Pet Have To Take Zentonil?

The length of administration depends on the actual problem. Acute or sudden onset conditions (such as liver poisoning) may show improvement within weeks. Chronic or long-standing conditions (such as cirrhosis or liver inflammation) may require months to years of administration. Your veterinarian is the best source of information regarding the duration of usage.

Will I Eventually Be Able To Reduce The Amount I Give To My Pet?

As mentioned above, a condition will often stabilize following administration of ZENTONIL. Your veterinarian will be able to determine future dosage based on your pet's response.

Do I Have To Buy Zentonil From My Veterinarian?

The importance of consulting your veterinarian should not be underestimated. Hepatic disorders are complex and difficult to diagnose, as well as manage. That is why ZENTONIL is available exclusively through your veterinarian. While there are similar products for sale over the counter and through mail order companies, ZENTONIL is produced under the strictest manufacturing conditions. We stand behind our products and veterinarians can trust the purity and consistency of our formulas.

Will Zentonil Interact With Any Other Products My Pet May Be Taking?

There are extensive studies proving the safety and efficacy of S-adenosylmethionine. As with all supplements, your veterinarian should consider all medication or treatment protocols currently in use.

Zentonil Administration Guide

For optimal absorption, ZENTONIL should be administered on an empty stomach (i.e. at least one hour before or two hours after feeding).

To protect ZENTONIL from destruction by stomach acids, tablets should not be split or crumbled.

In cases where it is difficult for the owner to administer a tablet, ZENTONIL may be disguised in a small bite of food or treat.

Storage

Store in a cool dry place. Keep tablets in their original blister pack until used. Tablets are sensitive to moisture and extreme heat.

References

Brown M.D., Dudeja P.K., Brasitus TA. S-Adenosyl-L-methionine modulates Na+ + K+-ATPase activity in rat colonic basolateral membranes. Biochem J 1988 Apr 1, 251(1): 215-22

Center S.A., Warner K.L., McCabe J. et al. Evaluation of the influence of S-adenosylmethionine on systemic and hepatic effects of prednisolone in dogs. Am. J. Vet. Res. 2005, 66(2), 330-341

Center S.A., Warner K.L., Erb H.N. Liver glutathione concentrations in dogs and cats with naturally occurring liver disease. Am. J. Vet. Res. 2002, 63(8), 1187-1197

Center S.A., Randolph J.F., Warner K. et al. Influence of S-adenosylmethionine on erythrocytes and liver tissue in healthy Cats. Proc. 18^th ACVIM, Seattle WA, 2002, 734

Center S.A. S-adenosylmethionine: an antioxidant and anti-inflammatory nutraceutical. Proc. 18^th ACVIM, Seattle, WA 2000, 550-553

Colell A., Garcia-Ruiz C., Morales A., et al. Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and S-adenosyl-L-methionine. Hepatol. 1997, 26(3), 699-708

Dunne J.B., Davenport M., Williams R., Tredger J.M. Evidence that S-adenosylmethionine and N-acetylcysteine reduce injury from sequential cold and warm ischemia in the isolated perfused rat liver. Transplantation 1994, 57(8), 1161-8

Dzanis D.A. Nutraceuticals: Food or drug? Proc. North Am. Vet. Conference 1998, Orlando, FL, 430-431

Friedel H.A., Goa K.L., Benfield P. S-adenosyl-L-methionine. A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism. Drugs. 1989, 38(3), 389-416. Review

Frezza M., Surrenti C., Manzillo G. et al. Oral S-Adenosyl-L-methionine in the symptomatic treatment of intrahepatic cholestasis. A double blind, placebo-controlled study. Gastroenterol. 1990, 99, 211-215

Kaye G.L., Blake J.C., Burroughs A.K. Metabolism of exogenous S-Adenosyl-L-methionine in patients with liver disease. Drugs 1990, 40 Suppl 3:124-8

Lieber C.S. S-Adenosyl-L-methionine: its role in the treatment of liver disorders. Am. J. Clin. Nutrition 2002, 76(suppl), 1183S-1187S

Mato J., Camara J., Fernandez de Paz, et al. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double blind, multicenter clinical trial. J. Hepatol. 1999, 30, 1081-1089

Moss R.L., Haynes A.L., Pastuszyn A., et al. Methionine infusion reproduces liver injury of parenteral nutrition cholestasis. Pediatr Res. 1999, 45(5 Pt 1): 664-8

New approach to managing hepatic dysfunction. Part I. Vet Forum 2000 Nov: 40-45

New approach to managing hepatic dysfunction. Part II. Vet Forum 2000 Nov: 44-49

Pisi E., Marchesini G. Mechanisms and consequences of the impaired transsulphuration pathway in liver disease: Part II. Clinical consequences and potential for pharmacological intervention in cirrhosis. Drugs 1990, 40(suppl 3), 65-72

Stramentinoli G. Pharmacologic aspects of S-adenosylmethionine. American Journal of Medicine 1987, 83(Suppl 5A), 35-42

Vendemiale G., Altomare E., Trizio T., et al. Effects of oral S-Adenosyl-L-methionine on hepatic glutathione in patients with liver disease. Scand. J. Gastroenterol. 1989, 24, 407-415

Wallace K.P., Center S.A., Hickford F.H., Warner K.L., Smith S. S-adenosyl-L-methionine (S-adenosylmethionine) for the treatment of acetaminophen toxicity in a dog. J. Am. Anim. Hosp. Assoc. 2002, 38(3), 246-254

Webster C.R.L., Boria P., Usechak P., Sawkat Anwer M. S-adenosylmethionine and cAMP confer differential cytoprotection against bile acid-induced apoptosis in canine renal tubular cells and primary rat heptatocytes. Vet. Therapeutics 2002, 3(4), 474-484

Watson P., et al. The use of S-adenosylmethionine in cats and dogs with liver disease. Proc. ECVIM-CA/ESVIM, Munich, 2002, 178

Vétoquinol N.-A. Inc., 2000 ch. Georges, Lavaltrie, QC, Canada J5T 3S5

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