Welactin Turn Back The Clock

HIGH-POTENCY NATURAL SALMON OIL SUPPLEMENT FOR DOGS

Convenient, highly palatable formulation to help support overall wellness.

Available only from your veterinarian

Guaranteed Analysis Per Pump - 1.5 Ml

(One fully depressed pump delivers approximately 1.5 mL)

INGREDIENTS: Salmon oil, d-alpha tocopheryl acetate, mono-and diglycerides, tocopherols, soybean oil, citric acid, and rosemary extract.

When measured by AOCS method Ce 1b-89 or calculated following measurement by AOCS Ce 1-62 per 1.5 mL.

Not recognized as an essential nutrient by the AAFCO Dog Food Nutrient Profiles.

Administration

Add to your dog's food once a day according to the chart below or as directed by your veterinarian.

many Of welactin's important Functions Are At Work Inside Your Dog's Body. While Using welactin, look For An Improvement In Your Dog's Activity Level, Attitude, Appetite, Alertness, And General Appearance.

once Opened, Store In A Cool Dry Place Away From Extreme Heat.

for Animal Use Only. Keep Out Of Reach Of Children.

what Is Welactin?

Welactin is a specially prepared salmon oil manufactured to maintain a high content of Omega 3 fatty acids. Welactin is manufactured in two separate formulations, Welactin for Cats, and Welactin for Dogs. Each has been carefully formulated for maximum palatability.

What Are Omega 3 Fatty Acids?

Specific fatty acids known as “Omega 3 fatty acids” are the “good health” fatty acids that you may have read about for human heart health. Humans have been encouraged to eat larger amounts of certain fish, which are high in Omega 3 fatty acids. The two predominant Omega 3 fatty acids are docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA).

How Can Welactin Help My Pet?

These two fatty acids have been shown in veterinary research to perform many functions. In dogs and pocket pets, Omega 3 fatty acids support a normal heart rhythm.^1-6 Omega 3 fatty acids support many other organ systems in the body, too, providing important benefits as pets age. Omega 3 fatty acids have been shown to protect kidney function,^7-15 which is especially important to older animals who are more prone to problems in kidney function. They also support the body's immune system,^16-18 again beneficial because as animals age, immune function may decrease. Omega 3 fatty acids can support skin and coat health as well.^19,20 Because the outer layer of skin cells “turns over” (sloughs off and is replaced by other cells), the skin can benefit from long-term administration of Omega 3 fatty acids.²¹

Welactin contains a higher proportion of the Omega 3 fatty acid DHA than do other fish oil products. This is ideal as DHA has a function in many organ systems. DHA is a major component of cell membranes. It affects fluidity and stability of cell membranes,^22,23 which means it has a key effect on every-day function of all of the cells in the body. More specifically, it is essential to early development of the brain and retina^22-24 and has been shown to be very important later in life as well in protecting brain cells;^25,26 a continual supply is needed as DHA is gradually broken down and eliminated.²⁷ This importance to the nervous system has been demonstrated in studies which showed that DHA supplementation has beneficial effects on brain function and learning^28-31 and on vision.³¹ Another study showed that dogs with compromised retinal function had lower levels of DHA in the bloodstream; therefore, supplementing with DHA may be helpful.²⁴

Administering DHA specifically rather than oils that contain precursor fatty acids to DHA may be important as some studies have shown that cats and dogs may not be able to readily use other fatty acids to make DHA in the body.^24,32,33

As this demonstrates, Welactin has far-reaching effects throughout the body and can help “turn back the clock” in your dog and “activate your cat ”!

How Do I Know That Welactin Is Absorbed By My Pet?

Welactin has been clinically evaluated in a carefully designed research study and was shown to increase levels of DHA in the blood three times over baseline levels in cats and more than five times over baseline levels in dogs.

What Changes Should I Expect To See In My Pet With Welactin?

While many of Welactin's important functions are at work inside your pet's body, changes that you may notice are an improvement in your pet's activity level, attitude, alertness, and general appearance.

How Do I Give Welactin?

Welactin is a tasty liquid and is easily administered with the accompanying pump over your pet's food. Please follow the administration instructions, which are based on your pet's weight, found on the label. In most cases, Welactin is administered longterm for continuing benefits.

Are Any Side Effects Seen In Animals Given Welactin?

No side effects were observed and no harmful effects on bloodwork were noted when Welactin was administered to cats and dogs in a trial. Rarely, side effects, including vomiting and diarrhea, itching, and lethargy, have been reported with other fish oil supplementation.³⁴ While there are no known interactions or side effects with administration of Welactin, if your pet has a medical condition, you should always consult with your veterinarian before administering any nutritional supplement or drug.

Doesn't My Pet Get Enough Omega 3 Fatty Acids From Food?

Another type of fatty acids are Omega 6 fatty acids. While the “natural diet” of animals in the past contained more balanced levels of Omega 6 and Omega 3 fatty acids,³⁵ pet foods today may have higher amounts of the Omega 6 fatty acids relative to the amounts of Omega 3 fatty acids.³⁶ Supplementing with the Omega 3 fatty acids in Welactin can, therefore, help re-establish the balance between these two kinds of fatty acids.

While some pet foods contain added levels of flaxseed oil, which contains alpha-linolenic acid, a precursor to DHA and EPA, the body may not be able to use it to make the DHA that the cells need.³² A few pet foods are fortified with the specific fatty acids DHA and EPA; however, levels are often well below the amounts found in Welactin. In addition, even if the amounts added are initially adequate, DHA and EPA are prone to break down so that they may not be maintained in the food. Welactin is specifically formulated to provide optimal amounts of DHA and EPA: levels that are both beneficial and safe for your pet.

Why Did My Veterinarian Recommend Welactin Instead Of Fish Oil Capsules Or Other Liquids?

The salmon oil found in Welactin differs from the fish oil found in capsules or other liquids in several ways - from palatability (how much your pet will like the taste) to levels of DHA and EPA.

In regards to palatability, Welactin has been evaluated in “taste tests” with dogs and cats.³⁷ When Welactin was added over the food, all of the dogs ate it. In addition, when dogs were then offered their food with and without Welactin, more of the dogs preferred their food with Welactin. In the cat taste test, Welactin was also shown to be palatable.

The levels of DHA and EPA are an issue in two ways. First, most other fish oils have a higher proportion of EPA, but Welactin has a higher proportion of DHA, with all of its important benefits, compared to these other supplements. Second, there is less oversight for supplements (compared to drugs), and a recent report showed that over 25% of fish oil products tested contained less DHA than what was listed on the label.³⁸ Another problem with fish oil products is that they can potentially turn rancid (they will then have a foul odor). In addition to containing vitamin E, which helps protect against this, Welactin contains other ingredients to help maintain freshness and stability. Finally, as heavy metal contamination is a potential problem with any fish-derived products, Welactin is monitored for the presence of heavy metals.

Where Can I Purchase Welactin?

Welactin is available only through your veterinarian. Your veterinarian can help you decide if Welactin is right for your pet and help you monitor your pet's response to it.

References

1. Freeman LM. Interventional nutrition for cardiac disease. Clin Tech Small Anim Pract 1998;13:232-7.

2. Freeman LM, Rush JE, Kehayias JJ, et al. Nutritional alterations and the effect of fish oil supplementation in dogs with heart failure. J Vet Intern Med 1998;12:440-8.

3. Leaf A, Kang JX, Xiao YF, et al. n-3 fatty acids in the prevention of cardiac arrhythmias. Lipids 1999;34 Suppl:S187-9.

4. Leaf A, Kang JX, Xiao YF, et al. The antiarrhythmic and anticonvulsant effects of dietary N-3 fatty acids. J Membr Biol 1999;172:1-11.

5. Leaf A, Xiao YF, Kang JX, et al. Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids. Pharmacol Ther 2003;98:355-77.

6. McLennan P, Howe P, Abeywardena M, et al. The cardiovascular protective role of docosahexaenoic acid. Eur J Pharmacol 1996;300:83-9.

7. Grauer GF, Greco DS, Behrend EN, et al. Effects of dietary n-3 fatty acid supplementation versus thromboxane synthetase inhibition on gentamicin-induced nephrotoxicosis in healthy male dogs. Am J Vet Res 1996;57:948-56.

8. Neumayer HH, Heinrich M, Schmissas M, et al. Amelioration of ischemic acute renal failure by dietary fish oil administration in conscious dogs. J Am Soc Nephrol 1992;3:1312-20.

9. Brown SA, Brown CA, Crowell WA, et al. Effects of dietary polyunsaturated fatty acid supplementation in early renal insufficiency in dogs. J Lab Clin Med 2000;135:275-86.

10. Brown SA, Finco DR, Brown CA. Is there a role for dietary polyunsaturated fatty acid supplementation in canine renal disease? J Nutr 1998;128:2765S-2767S.

11. Brown SA, Brown CA, Crowell WA, et al. Beneficial effects of chronic administration of dietary omega-3 polyunsaturated fatty acids in dogs with renal insufficiency. J Lab Clin Med 1998;131:447-55.

12. Brown SA, Finco DR. Fatty acid supplementation and chronic renal disease, in: D. P. Carey, S. A. Norton and S. M. Bolser, eds. Recent Advances in Canine and Feline Nutritional Research: Proceedings of the 1996 Iams International Nutrition Symposium. Wilmington, OH: Orange Frazer Press, 1996;159-167.

13. Brown SA, Brown CA, Crowell WA, et al. Does modifying dietary lipids influence the progression of renal failure? Vet Clin North Am Small Anim Pract 1996;26:1277-85.

14. Plantinga EA, Beynen AC. A case-control study on the intake of polyunsaturated fatty acids and chronic renal failure in cats. J App Res Vet Med 2003;1:127-131.

15. Plotnick AN. The role of omega-3 fatty acids in renal disorders. J Am Vet Med Assoc 1996;209:906-10.

16. Hall JA, Tooley KA, Gradin JL, et al. Effects of dietary n-6 and n-3 fatty acids and vitamin E on the immune response of healthy geriatric dogs. Am J Vet Res 2003;64:762-72.

17. Calder PC, Yaqoob P, Thies F, et al. Fatty acids and lymphocyte functions. Br J Nutr 2002;87 Suppl 1:S31-48.

18. Calder PC. Dietary modification of inflammation with lipids. Proc Nutr Soc 2002;61:345-58.

19. Scott DW, Miller WH, Jr., Reinhart GA, et al. Effect of an omega-3/omega-6 fatty acid-containing commercial lamb and rice diet on pruritus in atopic dogs: results of a single-blinded study. Can J Vet Res 1997;61:145-53.

20. Lechowski R, Sawosz E, Klucinski W. The effect of the addition of oil preparation with increased content of n-3 fatty acids on serum lipid profile and clinical condition of cats with miliary dermatitis. Zentralbl Veterinarmed A 1998;45:417-24.

21. Campbell KL. Clinical use of fatty acid supplements in dogs. Vet Dermatol 1993;4:167-173.

22. Youdim KA, Martin A, Joseph JA. Essential fatty acids and the brain: possible health implications. Int J Dev Neurosci 2000;18:383-99.

23. Dunbar BL, Bauer JE. Metabolism of dietary essential fatty acids and their conversion to long-chain polyunsaturated metabolites. J Am Vet Med Assoc 2002;220:1621-6.

24. Waldron MK, Spencer AL, Bauer JE. Role of long-chain polyunsaturated n-3 fatty acids in the development of the nervous system of dogs and cats. J Am Vet Med Assoc 1998;213:619-22.

25. Lim GP, Calon F, Ubeda O, et al. Diets enriched with polyunsaturated DHA (docosahexanoic acid) can lower amyloid levels and plaque burden in an Alzheimer's disease mouse model. Society for Neuroscience 2003.

26. De Wilde MC, Leenders I, Broersen LM, et al. The omega-3 fatty acid docosahexaenoic acid (DHA) inhibits the formation of beta amyloid in CHO7PA2 cells. Society for Neuroscience 2003.

27. Connor WE, Neuringer M, Lin DS. Dietary effects on brain fatty acid composition: the reversibility of n-3 fatty acid deficiency and turnover of docosahexaenoic acid in the brain, erythrocytes, and plasma of rhesus monkeys. J Lipid Res 1990;31:237-47.

28. Hashimoto M, Hossain S, Shimada T, et al. Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats. J Neurochem 2002;81:1084-91.

29. Morris MC, Evans DA, Bienias JL, et al. Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch Neurol 2003;60:940-6.

30. Ikemoto A, Ohishi M, Sato Y, et al. Reversibility of n-3 fatty acid deficiency-induced alterations of learning behavior in the rat: level of n-6 fatty acids as another critical factor. J Lipid Res 2001;42:1655-63.

31. Carrie I, Smirnova M, Clement M, et al. Docosahexaenoic acid-rich phospholipid supplementation: effect on behavior, learning ability, and retinal function in control and n-3 polyunsaturated fatty acid deficient old mice. Nutr Neurosci 2002;5:43-52.

32. Bibus DM, Stitt PA. Metabolism of alpha-linolenic acid from flaxseed in dogs. World Rev Nutr Diet 1998;83:186-98.

33. Pawlosky RJ, Denkins Y, Ward G, et al. Retinal and brain accretion of long-chain polyunsaturated fatty acids in developing felines: the effects of corn oil-based maternal diets. Am J Clin Nutr 1997;65:465-72.

34. Hall JA. Potential adverse effects of long-term consumption of (n-3) fatty acids. Compend Contin Educ Vet Pract 1996;18.

35. Hayek MG, Reinhart GA. Utilization of omega 3 fatty acids in companion animal nutrition. World Rev Nutr Diet 1998;83:176-85.

36. Roudebush P, Davenport DJ, Novotny BJ. The use of nutraceuticals in cancer therapy, in: L. Mandelker, ed. Vet Clin North Am Small Anim Pract 2004;34:249-269.

37. Data on file. Nutramax Laboratories, Inc., Edgewood, MD 21040, USA 2004.

38. Product review: omega-3 fatty acids (EPA and DHA) from fish/marine oils.

http://www.consumerlab.com/results/omega3.asp

Manufactured for: The Nutraceutical Company

NUTRAMAX^® LABORATORIES, INC., 2208 Lakeside Boulevard, Edgewood, Maryland 21040

1-800-925-5187

nutramaxlabs.com

Product manufactured in Chile

02-1003-01

Nac No.