Vetalar (Canada)This page contains information on Vetalar for veterinary use.
The information provided typically includes the following:
- Vetalar Indications
- Warnings and cautions for Vetalar
- Direction and dosage information for Vetalar
VetalarThis treatment applies to the following species:
Ketamine Hydrochloride Injection U.S.P.
For Veterinary Use only
Vetalar (ketamine hydrochloride) is a rapid acting, nonnarcotic, nonbarbiturate general anesthetic for cats, chemically designed 2 - (o-chlorophenyl)-2-methylamino-cyclohexanone hydrochloride. It is supplied as a slightly acid (pH 3.5-5.5) solution for intramuscular injection.
Ketamine (as ketamine hydrochloride) 100 mg/mL.
Non-Medicinal Ingredient: 0.01% w/v Benzethonium chloride (as preservative)
ACTION: Vetalar is a rapid acting anesthetic producing an anesthetic state characterized by profound analgesia, normal pharyngeal-laryngeal reflexes and skeletal muscle tone, mild cardiac stimulation and some respiratory depression. The anesthesia state produced by ketamine has been termed “dissociative anesthesia” in that it appears to selectively interrupt association of the brain before producing somesthetic sensory blockade.
Following administration of recommended doses of Vetalar, blood pressure and heart rate are usually moderately and transiently increased. Respiratory rate, on the other hand, is usually decreased in cats. The pharyngeal reflexes are maintained thus aiding in the maintenance of a patent airway. Although some salivation is occasionally noted, the persistence of the swallowing reflex effectively reduces the hazards of salivation.
Other reflexes, e.g. corneal, pedal, etc., are maintained under Vetalar anesthesia, and should not be used as criteria for depth of anesthesia. Moreover, the eyes normally remain open with the pupil dilated, making it prudent to apply a bland ointment if anesthesia is to be prolonged. By single intramuscular injection in cats Vetalar has a wide margin of safety.
Following administration of recommended doses of Vetalar most cats become ataxic in about 5 minutes, and anesthesia will normally last 30 - 45 minutes. Recovery is generally smooth and uneventful, especially if animals are not stimulated by sound or handling during the recovery period. At lower doses complete recovery usually occurs in 4 - 5 hours but with higher levels of Vetalar recovery time is more prolonged and less predictable. With high levels, complete recovery may take 24 hours or more in some selected cases especially if the patient is in poor condition or suffering from nephritis.
Vetalar is recommended as the sole anesthetic agent for diagnostic and surgical procedures. Although best suited to short procedures, it can be used, with additional doses, in procedures requiring anesthesia for periods of six hours or longer.
The use of Vetalar is not indicated in kittens under 12 weeks of age as it is not unusual in immature cats for anesthesia to be of shorter duration. Ketamine hydrochloride is contraindicated for procedures in cats requiring complete skeletal muscle relaxation.
CAUTIONS: Because the drug is excreted in the urine by cats, largely unchanged, caution should be exercised in dosing subjects with severe renal impairment. Caution should also be exercised in administering the drug to animals with cardio-vascular abnormalities due to its hypertensive effect in cats.
Premedication with atropine may, to some degree, deepen and prolong anesthesia in the cat.
Adverse ReactionsAt high dosage, respiratory depression may occur. If at any time cyanosis occurs, or if respiration becomes excessively depressed, resuscitative measures should be instituted promptly e.g. artificial respiration, oxygen administration, etc.
ADMINISTRATION AND DOSAGE: Vetalar is well tolerated by cats when administered by intramuscular injection.
Fasting prior to induction of anesthesia by Vetalar is not essential, however, when preparing for elective surgery it is prudent to withhold food for at least six hours prior to induction of anesthesia.
DOSAGE: As with other general anesthetic agents, the individual response to Vetalar is somewhat varied depending upon the dose, general condition, and age of the subject so that dosage recommendations cannot be absolutely fixed.
THE FOLLOWING SCHEDULE OF DOSAGE (BASE) IS RECOMMENDED:
11-22 mg/kg body weight: MINOR SURGERY, SUTURING, ETC., MINOR DENTAL PROCEDURES, SIMPLE DIAGNOSTIC X-RAY, RESTRAINT FOR EXAMINATION (INCLUDING INTERIOR OF EYE), DRESSING, GROOMING, ETC.
22-33 mg/kg body weight: CASTRATION, CATHETERIZATION, DECLAWING.
33-44 mg/kg body weight: GENERAL SURGERY, ABDOMINAL SURGERY (INCLUDING OVARIOHYSTERECTOMY), ORTHOPEDIC SURGERY, MAJOR DENTISTRY.
StorageStore at room temperature (15-30°C); protect from light.
NOTE: Colour of solution may vary from colourless to very slight yellowish and may darken upon prolonged exposure to light. This darkening does not affect potency. Do not use if precipitate appears.
SUPPLY: Vetalar is supplied as the hydrochloride in concentrations equivalent to Ketamine base.
Each 10 mL vial contains 100 mg/mL
Each 50 mL vial contains 100 mg/mL
BIONICHE ANIMAL HEALTH CANADA INC., P.O. Box 1570, Belleville, Ontario K8N 5J2
NAC No.: 12150298
BIONICHE ONE HEALTH
P.O. BOX 1570, 231 DUNDAS ST. E., BELLEVILLE, ON, K8N 1E2
|Every effort has been made to ensure the accuracy of the Vetalar information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.|
Copyright © 2014 North American Compendiums. Updated: 2013-12-23