Univax-Plus

Bursal Disease Vaccine

Live Virus

DRINKING WATER AND SUBCUTANEOUS ADMINISTRATION

Univax-Plus Caution

Federal regulations prohibit the repackaging or sale of the contents of this package in fractional units. Do not accept if seal is broken.

Read Full Directions Below Carefully

Use entire contents of vial when first opened.

Do not vaccinate within 21 days before slaughter.

Store vaccine in refrigerator under 45°F (7°C).

Gentamicin is added as a preservative.

CAUTION: Burn containers and all unused contents.

Description

UNIVAX-Plus is a live virus vaccine containing two live bursal disease viruses. The vaccine viruses have been demonstrated in controlled studies to provide protection against standard and variant bursal disease viruses. The vaccine viruses are grown in chicken embryos and cell culture, and are combined with stabilizing agents. The product is supplied as a lyophilized vaccine contained in vials sealed under vacuum.

Univax-Plus Indications For Use

The vaccine is recommended for the vaccination of chickens one day of age by subcutaneous route of administration or by drinking water at 2 weeks or older as an aid in preventing bursal disease associated with infection by standard and variant bursal disease viruses.

Vaccination Programs

Many factors must be considered in determining the proper vaccination program for a particular farm or poultry operation. To be fully effective, the vaccine must be administered to healthy receptive chickens held in a proper environment under good management. In addition, the response may be modified by the age of the chickens and their immune status. Seldom does one vaccination under field conditions produce complete protection for all individuals in a given flock. The amount of protection required will vary with the type of operation and the degree of exposure that a flock is likely to encounter. For these reasons a program of periodic revaccination may be required.

Precautions

ONLY VACCINATE HEALTHY CHICKENS

Consult your poultry pathologist for further recommendations based on conditions existing in your area at any given time. Different vaccines should not be mixed for single application. The vaccination program for replacement pullets should not be started after chickens are 16 weeks of age.

Chickens should not be placed on contaminated premises. Exposure should be avoided immediately after vaccination, because it takes up to 10 days to develop resistance. All susceptible chickens on the same premises should be vaccinated at the same time. If this is not possible, then strict isolation and separate caretakers should be employed for non-vaccinated units. Efforts should be taken to reduce stress conditions at the time the vaccine is administered.

Rehydration Of The Vaccine

FOR DRINKING WATER ADMINISTRATION

2,500 dose vials and 5,000 dose vials are for mass administration use only. Do not open and mix the vaccine until ready to begin vaccination. Use vaccine immediately after mixing

1. Tear off the aluminum seal from the vial containing the dried vaccine.

2. Lift off the rubber stopper.

3. Use cool, clean non-chlorinated water to which powdered milk has been added as directed.

4. Put back the rubber stopper and shake vigorously until all material is dissolved.

5. The vaccine is now ready for drinking water use in accordance with directions below. For best results be sure to follow directions carefully.

Drinking Water Administration

For chickens 2 weeks of age or older

1. Remove all medication, sanitizers, and disinfectants from the drinking water, preferably 72 hours before vaccinating and 24 hours following vaccination.

2. Provide enough watering space so that at least two-thirds of the chickens can drink at one time.

3. Scrub waterers thoroughly and rinse with fresh, clean water.

4. Withhold water for 2 hours before vaccinating to stimulate thirst.

5. Rehydrate the vaccine as directed above.

6. Drinking water for vaccination should be mixed with powdered milk to prevent inactivation from chlorine or other water additives and also to stabilize the vaccine virus. The powdered milk should be added to the water at the rate of 3 grams per 11 liters (1 heaped teaspoon per 3 US gallons or 2.5 Imp. gallons); or 90 grams per 300 liters (1 heaped cupful per 80 US gallons or 66 Imp. gallons).

7. Distribute the vaccine solution, as prepared above, among the waterers provided for the chickens. Avoid placing waterers in direct sunlight.

8. Provide no other drinking water until all the vaccine treated water has been consumed.

Rehydration Of Vaccine

FOR SUBCUTANEOUS ROUTE OF ADMINISTRATION:

1. Do not open and mix the vaccine until ready for use.

2. Mix only one vial at a time and use entire contents within 2 hours.

3. Lift up top of seal on vaccine vial to expose rubber stopper. Using sterile needle and 5 or 10 ml syringe, remove a small amount (5 ml) of diluent from a 500 ml diluent bottle (2,500 doses), or from a 1,000 ml diluent bottle (5,000 doses), and transfer this to the vaccine vial.

4. Vigorously shake vaccine vial with transferred diluent to rehydrate the vaccine.

5. Using the same sterile needle and syringe, completely transfer the rehydrated vaccine to remaining diluent in diluent bottle. Rinse syringe and vaccine vial by withdrawing a small amount of vaccine-diluent mixed solution and repeating the process.

6. Vigorously shake final rehydrated vaccine for 20-30 seconds to mix thoroughly.

7. The vaccine is now ready for use.

Subcutaneous Route Of Administration

Insert a filling tube (large, sharpened transfer tube) into the bottle of vaccine. Connect the filling tube by means of rubber or plastic tubing to an automatic vaccinator fitted with a 22-gauge 1/2 inch needle. The automatic vaccinator should be calibrated accurately ahead of time to deliver 0.2 ml.

Notice

All Schering Plough Animal Health vaccines released for sale meet the requirements of the licensing authority (US Department of Agriculture) in regard to safety, purity, potency and the capacity to immunize normal, susceptible chickens.

Univax-Plus Caution

The capacity of this vaccine to produce satisfactory results depends on many factors including, but not limited to, conditions of storage and handling by the user, administration of the vaccine, health and responsiveness of individual animals and degree of field exposure. Therefore, directions for use should be followed carefully.

The use of this vaccine is subject to applicable state and federal laws and regulations.

Store Vaccine In Refrigerator Under 45º F (7º C)

Made in the USA

Schering-Plough Animal Health, Millsboro, DE 19966 U.S.A.

U.S. Veterinary License No. 226

Nac No.