Tylan 200 (Canada)

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Tylan 200

This treatment applies to the following species:
Manufacturer: Elanco

Tylosin Injection

200 mg/mL

DIN 00103594

FOR VETERINARY USE ONLY

FOR USE IN BEEF CATTLE AND SWINE

AH 0206

DESCRIPTION:

Tylosin is an antibiotic substance produced by a strain of Streptomyces fradiae, an actinomycete. Tylan Injection is a sterile solution of tylosin base in 50% propylene glycol with 4% benzyl alcohol. Each mL contains 200 milligrams of tylosin activity.

PROPERTIES:

Tylan is relatively non-toxic. The oral LD50 in mice is greater than five grams per kilogram. In swine the LD50 by intramuscular route is approximately 1,000 milligrams per kilogram; by the oral route greater than five grams per kilogram.

Other studies in dogs, cats and swine further substantiate the safety of this antibiotic. Blood level studies have been conducted in cattle and swine comparing Tylan Injection to aqueous solutions of tylosin tartrate. A longer duration of activity was evidenced with Tylan Injection. Twenty-four hour levels can be expected in cattle with a single injection of this preparation. There has been no evidence of undue irritation in beef cattle at the site of injection.

Tylosin has an antibacterial spectrum that is essentially gram positive, but it is also active against certain gram negative organisms. It has also been found to be extremely active against Mycoplasma species.

INDICATIONS:

BEEF CATTLE: Tylan 200 Injection is effective for the treatment of pneumonia caused by strains of Pasteurella multocida and Actinomyces pyogenes sensitive to tylosin and contagious calf pneumonia and metritis caused by Actinomyces pyogenes.

SWINE: Tylan 200 Injection is effective for the treatment of erysipelas caused by Erysipelothrix rhusiopathiae, pneumonia caused by strains of Pasteurella multocida sensitive to tylosin and swine dysentery caused by Treponema hyodysenteriae sensitive to tylosin.

TABLE I In Vitro Activity of Tylosin Against Several Microorganisms Isolated from Animals

Microorganism

MIC* Broth (µg/mL)

1. Gram Positive Bacteria

Staphylococcus albus

0.78 - 1.56

Staphylococcus aureus

0.39 - 1.56

Streptococcus agalactia

0.39 - 0.78

Streptococcus dysgalactia

0.195 - 0.39

Streptococcus uberis

0.39 - 1.56

Actinomyces pyogenes

>0.1 - 0.78

Clostridium sp.

0.1

Micrococcus luteus

0.2

Erysipelothrix rhusiopathiae

1.0

2. Gram Negative Bacteria

Pasteurella haemolytica

25.0 - 50.0

Pasteurella multocida

3.12 - 50.0

Moraxella bovis

0.4

Haemophilus somnus

6.25 - 12.5

Bordetella bronchiseptica

>100

Escherichia coli

>100

Salmonella sp.

>100

Haemophilus gallinarum

6.25 - 12.5

Treponema hyodysenteriae

3.12 - >100

Fusobacterium necrophorum

1.56

3. Mycoplasma

Mycoplasma bovis

0.097

Mycoplasma dispar

0.195

Mycoplasma gallisepticum

0.05 - 0.1

Mycoplasma hyopneumoniae

0.19

Mycoplasma hyorhinis

0.097

Mycoplasma hyosynoviae

0.097 - 100

Mycoplasma synoviae

<0.097

*MIC = Minimum inhibitory concentration

DOSAGE AND ADMINISTRATION:

BEEF CATTLE: Inject intramuscularly a daily dose of 4 mL per 45 kg (100 lbs) body weight. This is the equivalent of 17.6 mg of tylosin per kg body weight (8 mg per pound body weight). Do not exceed 5 days of treatment. If no improvement is observed in 3 days the diagnosis should be reconfirmed.

SWINE: Inject intramuscularly a daily dose of 1/2 to 2 mL per 45 kg (100 lbs) body weight. This is the equivalent of 2.2 to 8.8 mg of tylosin per kg body weight (1 to 4 mg of tylosin per pound body weight).

Do not exceed 3 days of treatment. If no improvement is observed in 3 days the diagnosis should be reconfirmed.

NOTE:

For the most effective treatment of swine dysentery, inject with Tylan 200 Injection and follow immediately with Tylan Soluble in the drinking water for 3-10 days at the rate of 1 gram per 4 litres (1 gram per U.S. gallon). To prevent a recurrence of swine dysentery, feed Tylan 10 Premix (tylosin phosphate) at the rate of 5 kg (110 g activity) per tonne of finished feed for three weeks. After three weeks the level should be reduced to 2 kg (44 g activity) per tonne of finished feed. Swine receiving drinking water containing Tylan Soluble or feed containing 110 g activity Tylan 10 Premix should not be slaughtered for use in food less than 48 hours following the latest treatment with this drug. No withdrawal is required when Tylan 10 Premix is included in feed at the 44 g activity per tonne of finished feed level. Swine dysentery appears sporadically in swine herds in this country. Tylan 10 Premix should therefore only be used for treatment and prevention of dysentery in swine following diagnosis of the disease in the herd by a veterinarian.

CONDITIONS OF USE:

Do not mix Tylan 200 Injection with other injectable solutions as this may cause precipitation of the active ingredient.

WARNING:

1. Do not use in lactating dairy cattle.

2. Treated cattle must not be slaughtered for use in food for at least 21 days and treated swine for at least 14 days following the latest treatment with this drug.

CONTRA-INDICATIONS:

There are no known contra-indications at this time.

CAUTION:

Reactions to tylosin have been observed in sensitive animals. In swine, reactions have included oedema of rectal mucosa, mild anal protrusion, diarrhea, erythema and pruritus. Discontinuation of treatment effected an uneventful recovery. This product contains propylene glycol. Temporary irritation may occur at the site of injection. Avoid injection of more than 5 mL at any one site in swine or more than 10 mL in cattle. To avoid excessive trim, do not slaughter swine for at least 21 days after treatment or cattle for at least 42 days after treatment with this drug.

KEEP OUT OF REACH OF CHILDREN.

STORE IN A COOL PLACE NOT EXCEEDING 30° C.

Tylan 200 Injection is supplied in 250 mL vials.

*ELANCO®, Tylan® are registered trademarks of Eli Lilly and Company

Used under license by ELANCO/Division Eli Lilly Canada Inc.

ELANCO®, Division Eli Lilly Canada Inc., Guelph, Ontario, Canada N1G 4T2

250 mL

31/05/2007

NAC No.: 11840132

ELANCO
Division Eli Lilly Canada Inc.

RESEARCH PARK CENTRE, 150 RESEARCH LANE, SUITE 120, GUELPH, ON, N1G 4T2
Telephone:   519-821-0277
Order Desk:   800-773-7603
Fax:   519-821-7831
Website:   www.Elanco.ca
Every effort has been made to ensure the accuracy of the Tylan 200 information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2014 North American Compendiums. Updated: 2014-12-03

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