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Trivetrin Injection (Canada)

This page contains information on Trivetrin Injection for veterinary use.
The information provided typically includes the following:
  • Trivetrin Injection Indications
  • Warnings and cautions for Trivetrin Injection
  • Direction and dosage information for Trivetrin Injection

Trivetrin Injection

This treatment applies to the following species:
Manufacturer: Schering-Plough

Trimethoprim and Sulfadoxine Injection

Sterile Antibacterial

For Veterinary Use Only

DIN 02145995

Chemistry

The active ingredients of TRIVETRIN are a combination of trimethoprim and sulfadoxine which has been established in a ratio of 1:5.

Action

TRIVETRIN Injection contains trimethoprim, a synthetic antibacterial developed in the Wellcome Research Laboratories, and sulfadoxine, a sulfonamide. The two components of TRIVETRIN produce a sequential double blockade of bacterial metabolism, giving a level of activity many times greater than that obtained from either drug alone.

TRIVETRIN provides effective antibacterial activity against a wide range of infections caused by Gram-positive and Gram-negative bacteria.

TRIVETRIN has shown activity in vitro against the following organisms:

Very Sensitive Organisms

Escherichia coli, Clostridium spp., Shigella spp., Salmonella spp., Proteus mirabilis, Bacillus anthracis, Pasteurella spp., Haemophilus influenzae, Streptococcus zooepidemicus, Vibrio spp.

Sensitive Organisms

Streptococcus viridans, Brucella spp., Enterococci spp., Staphylococcus aureus including penicillinase-producing organisms, Klebsiella spp., Proteus spp., Actinomyces spp., Corynebacterium spp., Bordetella spp., Neisseria spp.

Moderately Sensitive Organisms

Enterobacter aerogenes, Nocardia spp.

Non-sensitive Organisms

Pseudomonas aeruginosa , Mycobacterium tuberculosis, Leptospira spp., Erysipelothrix rhusiopathiae

usually non-sensitive.

Trivetrin Injection Indications And Clinical Uses

TRIVETRIN Injection may be used in cattle and swine where potent systemic antibacterial action against a wide range of infections caused by sensitive organisms is required.

TRIVETRIN Injection is indicated in cattle for the treatment of:

Respiratory Tract Infections-bacterial Pneumonias Including Bovine Pneumonic Pasteurellosis (shipping Fever).

alimentary Tract Infections-primarily Enteric And Septicemic Colibacillosis And Salmonellosis.

other Infections-infectious Pododermatitis (foot Rot, Foul In The Foot) And Septicemias.

trivetrin Injection Is Indicated In Swine For The Treatment Of:

respiratory Tract Infections-bacterial Pneumonias.

alimentary Tract Infections-colibacillosis And Post-weaning Scours.

other Infections-mastitis-metritis-agalactia Syndrome Of Sows (mma) And Bacterial Arthritis.

contraindications

TRIVETRIN Injection should not be used in cattle or swine showing marked liver parenchymal damage or blood dyscrasias, nor in those with a history of sulfonamide sensitivity.

Adverse Reactions

No significant adverse reactions have been reported.

Precautions

With intravenous therapy generally, and sulfonamides in particular, hypersensitivity reactions can occur and should be appropriately treated with corticosteroids or epinephrine.

Temporary, local, irritating swellings are encountered occasionally after intramuscular injection of TRIVETRIN.

Warning

Milk taken from treated animals within 96 hours after the latest treatment must not be used in food. Treated animals must not be slaughtered for use in food for at least 10 days after the latest treatment with this drug.

Trivetrin Injection Dosage And Administration

TRIVETRIN Injection should be administered at a dose rate of 16 mg/kg bodyweight (3 mL per 45 kg [100 lb]) daily. In piglets weighing less than 4.5 kg (10 lb), do not exceed a dose of 0.5 mL.

Intramuscular injection is recommended for cattle and swine, but if a particularly rapid response is required in acute infections TRIVETRIN can be administered by slow intravenous injection.

Treatment should continue for 2-3 days after symptoms have subsided. The usual course of treatment is for not longer than 5 consecutive days.

Dosage Form

TRIVETRIN Injection is a solution containing 4% w/v trimethoprim and 20% w/v sulfadoxine in an organic solvent. Each mL contains 40 mg trimethoprim and 200 mg sulfadoxine.

Full details of TRIVETRIN Injection are contained in the Product Monograph which is available on request.

Imported by SCHERING-PLOUGH CANADA INC., POINTE-CLAIRE, QUÉBEC, H9R 1B4

100 mL, 250 mL and 500 mL

1742020B R1197

Schering-Plough Animal Health (SCHERING-PLOUGH CANADA INC.), Pointe-Claire, Québec, H9R 1B4

® Registered trademark of Schering-Plough Animal Health Corporation, used under license by Schering-Plough Canada Inc.

Nac No.

12080903
SCHERING-PLOUGH ANIMAL HEALTH
Division of Schering Canada Inc.

3535 TRANS CANADA HWY., POINTE CLAIRE, QC, H9R 1B4
Telephone:   800-605-2584
Telephone Orders:  
Quebec:   FRENCH: 800-361-2431 or 514-426-7340
Telephone:   ENGLISH: 800-361-6550 or 514-426-7344
Atlantic Provinces & Ontario:   800-361-6550
Fax Orders:   888-428-7400 or 514-428-7400
Telephone Orders:  
Manitoba/Saskatchewan/Alberta/British Columbia:   800-661-3134 or 403-236-7363
Fax Orders:   403-236-5196
Every effort has been made to ensure the accuracy of the Trivetrin Injection information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Trivetrin Injection product label or package insert.

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