SparMectin-EThis page contains information on SparMectin-E for veterinary use.
The information provided typically includes the following:
- SparMectin-E Indications
- Warnings and cautions for SparMectin-E
- Direction and dosage information for SparMectin-E
SparMectin-EThis treatment applies to the following species:
10 mg per mL
Liquid for Horses
FOR VETERINARIAN USE ONLY
Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian
SparMectin-E (ivermectin) Liquid for Horses has been formulated for professional administration by stomach tube or oral drench. One low-volume dose is effective against important internal parasites, including the arterial stages of Strongylus vulgaris, and bots.
Ivermectin is derived from the avermectins, a family of potent, broad-spectrum antiparasitic agents, which are isolated from fermentation of Streptomyces avermitilis.
SparMectin-E Liquid is a clear, ready-to-use solution with each mL containing 1% ivermectin (10 mg), 0.2 mL propylene glycol, 80 mg polysorbate 80, 9 mg sodium phosphate monobasic monohydrate, 1.3 mg sodium phosphate dibasic anhydrous, 1 mg butylated hydroxytoluene, 0.1 mg disodium edetate, 3% benzyl alcohol and purified water q.s. ad 100%.
Mode Of Action
Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).
The margin of safety is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.
SparMectin-E Liquid is indicated for the effective treatment and control of the following parasites in horses:
Large Strongyles: Strongylus vulgaris (adults and arterial larval stages), S. edentatus (adults and tissue stages) and Triodontophorus spp (adults).
Small Strongyles - including those resistant to some benzimidazole class compounds (adults and fourth-stage larvae): Cyathostomum spp, Cylicocyclus spp, Cylicostephanus spp and Cylicodontophorus spp.
(adults and fourth-stage larvae): Oxyuris equi.
Ascarids (adults and third- and fourth-stage larvae): Parascaris equorum.
Hairworms (adults): Trichostrongylus axei.
Large-mouth Stomach Worms
(adults): Habronema muscae.
Bots (oral and gastric stages): Gasterophilus spp.
(adults and fourth-stage larvae): Dictyocaulus arnfieldi.
(adults): Strongyloides westeri.
Summer Sores caused by Habronema and Draschia spp cutaneous third-stage larvae.
Dermatitis caused by neck threadworm microfilariae, Onchocerca sp.
SparMectin-E Liquid for Horses is formulated for administration by stomach tube (nasogastric intubation) or as an oral drench. The recommended dose is 200 mcg of ivermectin per kilogram (91 mcg/lb) of body weight. Each mL contains sufficient ivermectin to treat 110 lb (50 kg) of body weight: 10 mL will treat an 1100 lb (500 kg) horse.
Use a calibrated dosing syringe inserted into the bottle to measure the appropriate dose, or pour the SparMectin-E Liquid into a graduated cylinder for dose measurement. Use a clean syringe if accessing the bottle to avoid contaminating the remaining product.
Administration By Stomach Tube
(gravity or positive flow): The recommended dose can be used undiluted or diluted up to 40 times with clean tepid water (see Notes to Veterinarian). Use tepid water to flush any drug remaining in the tube into the horse’s stomach.
Administration By Drench:
For administration by this method, an undiluted dose is usually preferred. Clear the horse’s mouth of any food material, elevate the horse’s head, and using a syringe, deposit the appropriate dose in the back of the mouth. In order to avoid unnecessary coughing or the potential for material to enter the trachea and lungs, do not use excessive pressure (squirting), do not use a large (diluted) dose volume, and do not deposit the dose in the laryngeal area. Increased dose rejection may occur if the dose is deposited in the buccal space. Keep the horse’s head elevated and observe the horse to insure the dose is retained.
Suggested Parasite Control Program
All horses should be included in a regular parasite control program with particular attention being paid to mares, foals and yearlings. Foals should be treated initially at 6 to 8 weeks of age, and routine treatment repeated as appropriate. SparMectin-E effectively controls gastrointestinal nematodes and bots in horses. Regular treatment will reduce the chances of verminous arteritis and colic caused by Strongylus vulgaris. With its broad spectrum, ivermectin is well suited to be the major product in a parasite control program.
Ivermectin liquid may be used in horses of all ages including mares at any stage of pregnancy. Stallions may be treated without adversely affecting their fertility. These horses have been treated with no adverse effects other than those noted under Notes to Veterinarian.
The Material Safety Data Sheet (MSDS) contains more detailed occupational safety information. To report adverse effects, obtain an MSDS or for assistance, contact:
Sparhawk Laboratories, Inc.
Lenexa, KS 66215, USA
WarningDo not use in horses intended for human consumption.
Caution: SparMectin-E Liquid has been formulated specifically for use in horses only. This product should not be used in other animal species as severe adverse reactions, including fatalities in dogs, may result.
Refrain from smoking and eating when handling. Wash hands after use. Avoid contact with eyes. Keep this and all drugs out of reach of children.
Store in a tightly closed container at room temperature between 15° and 30°C (59°-86°F).
Protect SparMectin-E Liquid (undiluted or diluted) from light.
Studies indicate that when ivermectin comes in contact with the soil, it readily and tightly binds to the soil and becomes inactive over time. Free ivermectin may adversely affect fish and certain water-borne organisms on which they feed. Do not contaminate lakes, streams, or ground water by direct application or by improper disposal of drug containers. Dispose of drug container in approved landfill or by incineration.
Notes To Veterinarian
Swelling and itching reactions after treatment with ivermectin have occurred in horses carrying heavy infections of neck threadworm microfilariae, Onchocerca sp. These reactions were most likely the result of microfilariae dying in large numbers. Symptomatic treatment may be advisable. Healing of summer sores involving extensive tissue changes may require other therapy in conjunction with ivermectin. Reinfection, and measures for its prevention, should also be considered. Special consideration should be given to the effects or potential for injury from handling, restraint, and placement of the tube during administration by stomach tube. Ivermectin liquid should be administered by drench if the risks associated with tubing are of concern. Due to the consequences of improper administration (also see Dosage and Administration), SparMectin-E Liquid is intended for use by a veterinarian only and is not recommended for dispensing.
Ivermectin liquid in 1 to 20 and 1 to 40 dilutions with tap water has been shown to be stable for 72 hours under the conditions recommended for the product (i.e., at room temperature, in a tightly closed container, protected from light). The diluted product does not promote the growth of common organisms. However, prolonged storage of the diluted product cannot be recommended, as the effects of possible contaminants and interactions with untested materials are unknown.
SparMectin-E Liquid for Horses is available in a 100 mL plastic bottle. Each bottle contains sufficient ivermectin to treat 10-500 kg (1100 lb) horses. Contents may be poured into a graduated cylinder for dose measurement. Alternatively, a clean syringe may be inserted directly into the bottle to draw off the appropriate dose.
Made in U.S.A.
ANADA 200-341, Approved by FDA
Sparhawk Laboratories, Inc., Lenexa, KS 66215, USA
NAC No.: 10510030
12340 SANTA FE TRAIL DRIVE, LENEXA, KS, 66215
|Every effort has been made to ensure the accuracy of the SparMectin-E information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.|
Copyright © 2014 North American Compendiums. Updated: 2014-07-28