Rapinovet (Canada)

This page contains information on Rapinovet for veterinary use.
The information provided typically includes the following:
  • Rapinovet Indications
  • Warnings and cautions for Rapinovet
  • Direction and dosage information for Rapinovet

Rapinovet

This treatment applies to the following species:
Manufacturer: Merck Animal Health

Injection Propofol 10 Mg/ml

Sterile Intravenous Anesthetic For Dogs And Cats

For Veterinary Use Only

DIN 02138255

Propofol (RAPINOVET) is a substituted phenol which, when given by intravenous injection, is a short-acting anesthetic with a rapid rate of onset. After a single bolus dose blood level profiles are characterized by a rapid distribution phase and a rapid elimination phase. No accumulation of propofol blood levels has been observed after multiple daily dosing. Urinary excretion is the major route of elimination of metabolites from the body.

Active Ingredient

Each mL contains 10 mg propofol.

Rapinovet Indications

A short-acting, intravenous, general anesthetic for use in dogs and cats as follows:

1. As a single injection for induction of general anesthesia for procedures lasting less than five minutes.

2. For induction and maintenance of general anesthesia using incremental doses to effect. Propofol has only mild analgesic properties and when used as a maintenance agent should be restricted to minor surgical procedures such as endoscopy or cat castration. For more painful procedures the patient should be premedicated, induced with propofol and maintained with inhalation agents as in 3) below.

3. For induction of general anesthesia where maintenance is provided by gaseous anesthetics.

Rapinovet Is Particularly Suitable For Cases Where A Short Recovery Period Is Required.

dosage And Administration

Dose

1. INDUCTION - The induction dose is computed according to bodyweight and may be given in full, as a single dose. Alternatively, the computed dose may be administered to effect over a period of 10-40 seconds. The induction dose is reduced by the use of premedicants.

It should be noted that the dose rates shown are for guidance and in practice the dose rate should be based on response. The average induction dose for cats and dogs, either unpremedicated or when premedicated with a tranquilizer such as acepromazine, is indicated as follows:

 

Dose rate mg/kg bodyweight

Dose volume mL/kg bodyweight

DOGS

Unpremedicated

6.5

6.5 mL/10 kg

Premedicated

4.0

4.0 mL/10 kg

CATS

Unpremedicated

8.0

2.0 mL/2.5 kg

Premedicated

6.0

1.5 mL/2.5 kg

2. MAINTENANCE BY RAPINOVET - Where anesthesia is maintained by incremental injections, the dose rate will vary between animals. Incremental doses should be given to effect. Experience in clinical trials has shown that doses of around 1 mL per 4.0-8.0 kg bodyweight sustain anesthesia for periods up to five minutes.

3. MAINTENANCE BY INHALATION AGENTS - Where inhalation agents are used to maintain general anesthesia, clinical experience indicates that there may be a need to use a higher initial concentration of inhalation agent than is normally the case following induction with barbiturate agents such as thiopentone.

Administration

- By intravenous injection only.

- The vial should be shaken thoroughly before opening.

- The emulsion should not be mixed with other therapeutic agents or infusion fluids prior to administration.

Rapinovet Has Been Used In Association With Commonly Used Premedicants, E.g., Atropine, Acepromazine, Diazepam, Inhalational Agents, E.g., Halothane, Nitrous Oxide, Enflurane; And Analgesic Agents, E.g., Pethidine, Buprenorphine. No Pharmacological Incompatibility Has Been Encountered. Inadvertent Perivascular Administration Has Not Been Found To Produce Local Tissue Reactions.

contraindication

None.

Rapinovet Caution

During induction of anesthesia, mild hypotension and transient apnea, similar to effects with other intravenous anesthetic agents, may occur. When using RAPINOVET, facilities for the maintenance of a patient’s airway, artificial ventilation, and oxygen enrichment should be available. As with other intravenous anesthetic agents, caution should be applied in dogs and cats with cardiac, respiratory, renal or hepatic impairment, or in hypovolemic or debilitated animals.

Rapinovet Has Not Been Used In Cats And Dogs Where The Pregnancy Is To Be Maintained, But Has Been Used For Induction Prior To Caesarean Section In Bitches. If Injected Very Slowly, An Inadequate Plane Of Anesthesia May Result.

side Effects

Induction is generally smooth in dogs and cats. In clinical trials, excitement phenomena including, nystagmus, paddling of limbs, focal muscle twitching and opisthotonous were seen in 11% of cats and dogs anesthetized. These signs were transient and may be reduced by use of premedication. In clinical trials in cats, transient apnea during induction and a paw/face-licking characteristic during recovery have been observed in a small proportion of cases. If panting is evident before induction, it may continue throughout the subsequent periods of anesthesia and recovery. Side effects during maintenance and recovery are uncommon.

Overdosage

Accidental overdosage is likely to cause cardio-respiratory depression. Respiratory depression should be treated by artificial ventilation with oxygen. Cardiovascular depression requires the use of plasma expanders and pressor agents.

Storage

Store between 2° and 25°C. Do not freeze.

Any portion of the contents of a vial remaining after use should be discarded.

Presentation

10 vials of 20 mL - Product Code: 0068014

® Registered trademark of Schering-Plough Animal Health Corporation, used under license by Intervet Canada Corp.

Intervet Canada Corp., 16750, route Transcanadienne, Kirkland QC, H9H 4M7

For technical enquiries, call toll free 1 888 306-0069.

0090366

02-0025INS

Nac No.

12080806

MERCK ANIMAL HEALTH
Intervet Canada Corp.
16750 ROUTE TRANSCANADIENNE, KIRKLAND, QC, H9H 4M7
Order Desk:   514-428-7013
Toll-Free:   866-683-7838
Fax:   Toll-free 888-498-4444; local 514-428-7014
Website:   www.merck-animal-health.ca
Every effort has been made to ensure the accuracy of the Rapinovet information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2014 North American Compendiums. Updated: 2014-04-11

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