PZI VETThis page contains information on PZI VET for veterinary use.
The information provided typically includes the following:
- PZI VET Indications
- Warnings and cautions for PZI VET
- Direction and dosage information for PZI VET
Pzi VetThis treatment applies to the following species:
(protamine Zinc Insulin)
Active Ingredient(s)PZI VET® insulin is a white to off-white sterile injectable suspension that contains 40 International Units (U) of insulin per milliliter. It is formulated within a pH range of 7.1 to 7.4. Inactive ingredients include phenol, glycerin, dibasic sodium phosphate, and sterile water for injection.
PZI VET IndicationsPZI VET® insulin is indicated for the reduction of hyperglycemia and hyperglycemia-associated clinical signs in cats with diabetes mellitus.
PharmacologyDescription PZI VET® insulin is composed of a mixture of 90% beef and 10% pork insulin. Species differences in insulin structure occur due to amino acid substitutions. Feline insulin differs from bovine insulin by one amino acid and from porcine insulin by four amino acids.1,2
The insulin is complexed with protamine zinc to form a microcrystalline suspension that results in prolonged dissolution, delivery and an extended duration of effect.3,4
PZI VET Dosage And AdministrationPZI VET® insulin should be administered subcutaneously. Dosage regimens of PZI VET® insulin will vary among patients. The recommended starting dose is 0.1-0.3 U per pound of body weight (0.22-0.6 U/kg) every 12 to 24 hours. This dose should be adjusted based on changes in blood glucose levels and resolution of clinical signs. Further adjustments in dosage may be necessary with changes in the cat's diet, body weight, or concomitant medication, or if the cat develops concurrent infection, inflammation, neoplasia, or an additional endocrine or other medical disorder.5
The time course of action of all insulin types may vary within and between individual patients. The duration also depends on the site of injection, concurrent secretion of insulin antagonistic hormones and the cat's hydration status and physical activity level.
The vial should be gently rolled to re-suspend the insulin before each use. Do not shake. PZI VET® insulin should appear uniformly cloudy or milky after re-suspending. Do not use if a pellet of white material remains at the bottom of the vial after re-suspending. Do not use if clumps are apparent after re-suspending.
Drug InteractionsInsulin requirements may be increased by medications with hyperglycemic activity, most notably glucocorticoids and progestagens.8,9 Insulin requirements may be decreased by medications with antidiabetic activity, such as oral hypoglycemic drugs, or antihyperglycemic drugs.
Contraindication(s)PZI VET® insulin is contraindicated during episodes of hypoglycemia and in cats sensitive to protamine zinc insulin or any other ingredients in PZI VET® insulin.
Precaution(s)Storage Conditions: Store at 2°-8°C (36°-46°F). Do not freeze. Do not expose to direct sunlight.
PZI VET Caution(s)Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
Any change in insulin should be made cautiously and only under a veterinarian's supervision. Changes in insulin strength, manufacturer, type, species (animal, human) or method of manufacture (rDNA versus animal-source insulin) may result in the need for a change in dosage.
Use PZI VET® with U-40 syringes only. Use of a syringe other than a U-40 syringe will result in incorrect dosing.
General: Hypoglycemia, hypokalemia, hypophosphatemia and allergic reactions are among the clinical adverse effects associated with the use of insulin.5,6 Care should be taken in dosing cats with inappetence or vomiting.
Hypoglycemic reaction may be associated with the administration of PZI VET® (see Warnings). Common causes for hypoglycemia include excessive doses of insulin, failure to eat, overlap of insulin activity in cats treated twice daily, strenuous exercise, correction of obesity or other insulin antagonistic disorders, concomitant use of oral antidiabetic drugs, discontinuation of insulin antagonistic drugs, and reversion to a noninsulin-dependent state.5,7
Mixing and Diluting of Insulins: Diluting PZI VET® insulin or mixing it with other insulins is not recommended.
For animal use only.
Warning(s)Keep out of reach of children.
Human safety: Contact your physician immediately in case of accidental injection with this insulin product.
Animal safety: Use of this product, even at established doses, has been associated with hypoglycemia. An animal with signs of hypoglycemia should be treated immediately. Glucose should be given orally or intravenously as dictated by clinical signs. Insulin should be temporarily withheld and, subsequently, the dosage should be adjusted, if indicated.
Adverse ReactionsHypoglycemia with and without associated clinical signs (lethargy, shakiness, and seizures) may be observed after treatment with PZI VET®. To report adverse reactions, call 1-800-374-8006.
ReferencesAvailable upon request.
PZI VET is a trademark of Idexx Pharmaceuticals, Inc.
Presentation10 mL multiple dose vials, each mL containing 40 U protamine zinc insulin.
A Subsidiary of Idexx Laboratories, Inc.
4249-105 PIEDMONT PARKWAY, GREENSBORO, NC, 27410
|Every effort has been made to ensure the accuracy of the PZI VET information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.|
Copyright © 2014 North American Compendiums. Updated: 2014-05-28