Phenylbutazone Tablets

This page contains information on Phenylbutazone Tablets for veterinary use.
The information provided typically includes the following:
  • Phenylbutazone Tablets Indications
  • Warnings and cautions for Phenylbutazone Tablets
  • Direction and dosage information for Phenylbutazone Tablets

Phenylbutazone Tablets

This treatment applies to the following species:
Manufacturer: RXV

For Horses

INGREDIENTS: Each tablet contains:

Phenylbutazone, U.S.P.

1 gram

Plus excipients.

Description & Pharmacology:

Phenylbutazone chemically is 4-butyl-1, 2-diphenyl-3, 5-pyrazolidinedione. It has the following structural formula:

Phenylbutazone was first synthesized in 1948 and introduced into human medicine in 1949, Kuzell1,2,3, Payne4, Fleming5, and Denko6, demonstrated the clinical effectiveness of phenylbutazone in gout, gouty arthritis, acute arthritis, acute rheumatism and various other rheumatoid disorders in humans. Fabre7, Domenjoz8, Wilhelmi9, and Yourish10, have established the anti-rheumatic and anti-inflammatory activity of phenylbutazone. It is entirely unrelated to the steroid hormones.

Toxicity of phenylbutazone has been investigated in rats and mice11, Ogilvie and Sutter12, have also made a study on the chronic toxicity of phenylbutazone in dogs. They have shown that dogs receiving 10 mg. and 100 mg. per Kg. body weight, per day for 90 days, maintain good appetites, excrete normal feces, gain weight and maintain a normal blood picture. They also report no abnormal macroscopic or microscopic changes in sacrificed animals which could have been attributed to the drug.

Phenylbutazone has been used by Camberos13 in thoroughbred horses. Favorable results were reported in cases of traumatism, muscle rupture, strains and inflammations of the third phalanx. Results were not as favorable in the periodic treatment of osteo-arthritis of medial and distal bones of the hock, arthritis of the stifle and hip, arthrosis of the trapezious muscles, and generalized arthritis. Sutter14 reported a favorable response in chronic equine arthritis of long duration, fair results in a severely bruised mare, and poor results in two cases where the condition was limited to the third phalanx.

Phenylbutazone Tablets Indications

Phenylbutazone is for the relief of inflammatory conditions associated with the musculoskeletal system in horses.

A non-hormonal anti-inflammatory agent.

DOSAGE & ADMINISTRATION: For horses only.

HORSES: Orally - 1 to 2 tablets per 500 lb. body weight. DO NOT EXCEED 4 GRAMS DAILY. Reduce dosage as symptoms regress. Intermittent treatment given only when symptoms appear may be indicated.

Contraindications

Use with caution in patients who have a history of drug allergy.

PRECAUTION: In the treatment of inflammatory conditions associated with infections, specific anti-infective therapy should be used concurrently.

Warning

Not for use in horses intended for food.

Phenylbutazone Tablets Caution

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Storage

Store at controlled room temperature between 15°-30°C (59°-86°F). Keep container tightly closed when not in use.

AVAILABILITY: Available in 1 gm. tablets - 100 tablets per bottle.

REFERENCES

1. Kuzell, W.C., Schaffarzick, R.W., Naughler, W.E., Gandia, G. and Mankle, E.A.: A.M.A. Arch, Inst. Med., 92; 646 (1953).

2. Kuzell, W.C., Schaffarzick, R.W., Brown, B. and Mankle, E.A.: J.A.M.A. 149; 729 (1952).

3. Kuzell, W.C., and Schaffarzick, R.W.: Calif. Med. 77; 319 (1952).

4. Payne, R.W., Shelter, M.R., Farr, C.H., Hellbaum, A.A. and Ishmall, W.K.: J. Lab. Clin. Med. 45; 331 (1955).

5. Fleming, J., and Will, G.: Ann. Rheumat., Dis., 12; 95 (1953).

6. Denko, C.W., and Rumi, D.: American Pract. 6; 1865 (1955).

7. Fabre, J., et al: Semain. Hop. (Paris) 31; 87 (1955).

8. Domenjoz, R., et al: Arzneimittel-Forsch, 5; 488 (1955).

9. Wilhelmi, G. and Pulver, R.: Arzneimittel-Forsch, 5; 221 (1955).

10. Yourish, W., Paton, B., Brodie, B., Burns, J.: A.M.A. Arch. Ophth., 53: 264 (1955).

11. Hazelton, L.W., Tusing, T.W. and Hollana, E.G.: J. Pharmacol. Exper. Ther., 109; 387 (1953).

12. Ogilvie, F.B. and Sutter, M.D.: Vet. Med. 52; 492-4 (1957).

13. Camberos, H.R.: Rev. Med. Vet. (Buenos Aires) 38; 9 (1956).

14. Sutter, M.D.: Vet. Med., 53; 83 (Feb. 1958).

For Animal Use Only - Keep Out of Reach of Children

Manufactured for: RXVeterinary Products, Westlake, TX 76262 U.S.A.

NADA 048-647, Approved by FDA

Net Contents:

NDC#

 

100 Tablets

64556-313-10

Iss. 04-05

NAC No.: 10910691

RXV
822 7TH STREET, SUITE 605, GREELEY, CO, 80631
Telephone:   817-859-3000
Every effort has been made to ensure the accuracy of the Phenylbutazone Tablets information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2014 North American Compendiums. Updated: 2014-07-28

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