Medication Guide App

Panolog Ointment

This page contains information on Panolog Ointment for veterinary use.
The information provided typically includes the following:
  • Panolog Ointment Indications
  • Warnings and cautions for Panolog Ointment
  • Direction and dosage information for Panolog Ointment

Panolog Ointment

This treatment applies to the following species:
Manufacturer: Zoetis

NYSTATIN-NEOMYCIN SULFATE-THIOSTREPTON-TRIAMCINOLONE ACETONIDE OINTMENT USP

FOR USE IN DOGS AND CATS ONLY

NADA 12-258, Approved by FDA

Panolog Ointment Caution

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Description

Panolog Ointment (Nystatin-Neomycin Sulfate-Thiostrepton-Triamcinolone Acetonide Ointment USP) combines nystatin, neomycin sulfate, thiostrepton and triamcinolone acetonide in a non-irritating, protective vehicle, a Plasticized Hydrocarbon Gel (polyethylene and mineral oil gel base).

Each mL contains:

Nystatin

100,000 units

Neomycin sulfate equivalent to neomycin base

2.5 mg

Thiostrepton

2,500 units

Triamcinolone acetonide

1.0 mg

The preparation is intended for local therapy in a variety of cutaneous disorders of cats and dogs; it is especially useful in disorders caused, complicated or threatened by bacterial and/or candidal (monilial) infection.

Actions

By virtue of its four active ingredients, Panolog Ointment provides four basic therapeutic effects; anti-inflammatory, antipruritic, antifungal and antibacterial. Triamcinolone acetonide is a potent synthetic corticosteroid providing rapid and prolonged symptomatic relief on topical administration. Inflammation, edema and pruritus promptly subside and lesions are permitted to heal. Nystatin is the first well-tolerated antifungal antibiotic of dependable efficacy for the treatment of cutaneous infections caused by Candida albicans (Monilia). Nystatin is fungistatic in vitro against a variety of yeast and yeast-like fungi including many fungi pathogenic to animals. No appreciable activity is exhibited against bacteria. Thiostrepton has a high order of activity against gram-positive organisms, including many which are resistant to other antibiotics: neomycin exerts antimicrobial action against a wide range of gram-positive and gram-negative bacteria. Together they provide comprehensive therapy against those organisms responsible for most superficial bacterial infections.

Panolog Ointment Indications

Panolog Ointment is particularly useful in the treatment of acute and chronic otitis of varied etiologies, in interdigital cysts in cats and dogs and in anal gland infections in dogs.

The preparation is also indicated in the management of dermatologic disorders characterized by inflammation and dry or exudative dermatitis, particularly those caused, complicated or threatened by bacterial or candidal (Candida albicans) infections. It is also of value in eczematous dermatitis, contact dermatitis and seborrheic dermatitis; and as an adjunct in the treatment of dermatitis due to parasitic infestation.

Warnings

Clinical and experimental data have demonstrated that corticosteroids administered orally or by injection to animals may induce the first stage of parturition if used during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta and metritis.

Additionally, corticosteroids administered to dogs, rabbits and rodents during pregnancy have resulted in cleft palate in offspring. Corticosteroids administered to dogs during pregnancy have also resulted in other congenital anomalies including deformed forelegs, phocomelia and anasarca.

Precautions

Panolog Ointment (Nystatin-Neomycin Sulfate-Thiostrepton-Triamcinolone Acetonide Ointment USP) is not intended for the treatment of deep abscesses or deep-seated infections such as inflammation of the lymphatic vessels. Parenteral antibiotic therapy is indicated in these infections.

Panolog Ointment has been extremely well tolerated. Cutaneous reactions attributable to its use have been extremely rare. The occurrence of systemic reactions is rarely a problem with topical administration. There is some evidence that corticosteroids can be absorbed after topical application and cause systemic effects. Therefore, an animal receiving Panolog Ointment therapy should be observed closely for signs such as polydipsia, polyuria and increased weight gain.

Panolog Ointment is not generally recommended for the treatment of deep or puncture wounds or serious burns.

Sensitivity to neomycin may occur. If redness, irritation or swelling persists or increases, discontinue use. Do not use if pus is present since the drug may allow the infection to spread. Keep this and all medications out of the reach of children.

Avoid ingestion. Oral or parenteral use of corticosteroids, depending on dose, duration and specific steroid, may result in inhibition of endogenous steroid production following drug withdrawal.

Side Effects

SAP and SGPT (ALT) enzyme elevations, polydipsia and polyuria have occurred following parenteral or systemic use of synthetic corticosteroids in dogs. Vomiting and diarrhea (occasionally bloody) have been observed in dogs.

Cushing’s Syndrome in dogs has been reported in association with prolonged or repeated steroid therapy. Temporary hearing loss has been reported in conjunction with treatment of otitis. However, regression usually occurred following withdrawal of the drug. If hearing dysfunction is noted during the course of treatment, discontinue use of Panolog Ointment.

Panolog Ointment Caution

Before instilling any medication into the ear, examine the external ear canal thoroughly to be certain the tympanic membrane is not ruptured in order to avoid the possibility of transmitting infection to the middle ear as well as damaging the cochlea or vestibular apparatus from prolonged contact. If hearing or vestibular dysfunction is noted during the course of treatment, discontinue use of Panolog Ointment.

Panolog Ointment Dosage And Administration

Frequency of administration is dependent on the severity of the condition. For mild inflammations, application may range from once daily to once a week; for severe conditions Panolog Ointment may be applied as often as two to three times daily, if necessary. Frequency of treatment may be decreased as improvement occurs.

Otitis: Clean ear canal of impacted cerumen. Inspect canal and remove any foreign bodies such as grass awns, ticks, etc. Instill three to five drops of Panolog Ointment.

Infected anal glands, cystic areas, etc.: Drain gland or cyst and then fill with Panolog Ointment.

Other dermatologic disorders: Clean affected areas, removing any encrusted discharge or exudate. Apply Panolog Ointment sparingly in a thin film.

How Supplied

Panolog Ointment is supplied in tubes of 1/4 fl. oz. (7.5 mL), 1/2 fl. oz. (15 mL) and 1 fl. oz. (30 mL) each with an elongated tip for easy application.

Do not store above 86°F (30°C).

© 2005 Fort Dodge Animal Health. All Rights Reserved.

Fort Dodge Animal Health, Fort Dodge, Iowa 50501 USA

02995

Revised October 2005

4212840D

 

NDC

7.5 mL tube

53501-581-19

7.5 mL tube x 144

53501-581-78

15 mL tubes

53501-581-17

15 mL tube x 72

 

30 mL tubes

53501-581-28

NAC No.: 10031434

ZOETIS INC.
333 PORTAGE STREET, KALAMAZOO, MI, 49007
Telephone:   269-833-4000
Customer Service:   800-733-5500 and 800-793-0596
Veterinary Medical Investigations & Product Support:   800-366-5288
Technical Services (USA):   800-366-5288
Website:   www.zoetis.com
Every effort has been made to ensure the accuracy of the Panolog Ointment information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2014 North American Compendiums. Updated: 2014-05-28

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