P.G. 600 (Canada)

FOR VETERINARY USE ONLY

DESCRIPTION

Gilts normally reach puberty (begin experiencing normal estrus cycles and exhibiting regular estrus or heat) at any time between six and eight months of age, although some gilts will not have exhibited their first estrus at ten months of age. Age at first estrus is influenced by several factors including breed type, season of the year, environmental conditions and management practice. (Hurtgen, 1986)

Sows normally exhibit estrus three to seven days after weaning their litters; however, some otherwise healthy sows may not exhibit estrus for 30 days or more after weaning (Dial and Britt, 1986). The causes of delayed return to estrus in healthy sows are poorly understood, but probably include season of the year (so-called seasonal anestrus; Hurtgen, 1979), adverse environmental conditions, such as high ambient temperatures (Love, 1978), and the number of previous litters, because the condition is more prevalent after the first litter than after later litters (Hurtgen, 1986).

P.G. 600 is a combination of serum gonadotrophin (Pregnant Mare Serum Gonadotrophin or PMSG) and chorionic gonadotrophin (Human Chorionic Gonadotrophin or HCG) for use in prepuberal gilts (gilts that have not yet exhibited their first estrus) and in sows at weaning. It is supplied in freeze-dried form with sterile diluent for reconstitution.

In gilts and sows, the action of serum gonadotrophin is similar to the action of Follicle-Stimulating Hormone (FSH), which is produced by the animals' anterior pituitary gland. It stimulates the follicles of the ovaries to produce mature ova (eggs), and it promotes the outward signs of estrus (heat).

The action of chorionic gonadotrophin in gilts and sows is similar to the action of Luteinizing Hormone (LH), which is also produced by the animals' anterior pituitary gland. It causes the release of mature ova from the follicles of the ovaries (ovulation), and it promotes the formation of corpora lutea, which are necessary for the maintenance of pregnancy once the animals have become pregnant.

The combination of serum gonadotrophin and chorionic gonadotrophin in P.G. 600 induces fertile estrus in most prepuberal gilts and weaned sows three to seven days after administration (Schilling and Carne, 1972; Britt et al., 1986; Bates et al., 1991). The animals may then be mated or, in the case of gilts, mating may be delayed until the second estrus after treatment.

NOTE: P.G. 600 IS INTENDED AS A MANAGEMENT TOOL TO IMPROVE REPRODUCTIVE EFFICIENCY IN SWINE PRODUCTION OPERATIONS. TO OBTAIN MAXIMUM BENEFIT FROM THIS PRODUCT, ESTRUS DETECTION AND OTHER ASPECTS OF REPRODUCTIVE MANAGEMENT MUST ALSO BE ADEQUATE. IF YOU ARE IN DOUBT ABOUT THE ADEQUACY OF YOUR BREEDING PROGRAM, CONSULT YOUR VETERINARIAN.

P.G. 600 is available in two package sizes.

Single dose vials - Five 5 mL vials containing white, freeze-dried powder, plus five 5 mL vials containing sterile diluent. When reconstituted, each single dose vial (5 mL) of P.G. 600 contains:

Five dose vials - One 10 mL vial containing white, freeze-dried powder, and one 25 mL vial containing sterile diluent. When reconstituted, the five dose vial (25 mL) of P.G. 600 contains:

INDICATIONS FOR USE

PREPUBERAL GILTS: P.G. 600 is indicated for induction of fertile estrus (heat) in healthy prepuberal (non-cycling) gilts over five and one-half months of age and weighing at least 85 kg (185 lb).

SOWS AT WEANING: P.G. 600 is indicated for induction of estrus in healthy weaned sows experiencing delayed return to estrus.

CAUTIONS

Treatment will not induce estrus in gilts that have already reached puberty (begun to cycle). Gilts that are less than five and one-half months of age or that weigh less than 85 kg (185 lb) may not be mature enough to continue normal estrus cycles or maintain a normal pregnancy to full term after treatment. Treatment will not induce estrus in sows that are returning to estrus normally three to seven days after weaning. Delayed return to estrus is most prevalent after the first litter; the effectiveness of P.G. 600^® has not been determined after later litters. Delayed return to estrus often occurs during periods of adverse environmental conditions, and sows mated under such conditions may farrow smaller than normal litters.

WARNING

Treated animals must not be slaughtered for use in food for at least 7 days after the latest treatment.

DOSAGE AND ADMINISTRATION

One dose (5 mL) of reconstituted P.G. 600, containing 400 IU serum gonadotrophin and 200 IU chorionic gonadotrophin, should be injected subcutaneously into the gilt's or sow's neck behind the ear.

DIRECTIONS FOR USE

Single dose vials: Using a sterile syringe and a sterile hypodermic needle, transfer the contents of one vial of sterile diluent into the vial of freeze dried powder. Shake the vial gently to dissolve the powder. Inject the contents of the vial subcutaneously into the gilt's or sow's neck behind the ear.

Five dose vials: Using a sterile syringe and a sterile hypodermic needle, transfer approximately 5 mL of the sterile diluent into the vial of freeze dried powder. Shake the vial gently to dissolve the powder.

Transfer the dissolved product back into the vial of diluent and shake the vial gently to mix. Inject one dose (5 mL) of the reconstituted solution subcutaneously into the gilt's or sow's neck behind the ear.

STORAGE PRECAUTIONS

Refrigerate at 2-8°C (36-46°F). Once reconstituted, P.G. 600 should be used immediately. Unused solution should be disposed of properly and not stored for future use. In case of anaphylaxis administer 2 to 3 mL of epinephrine.

PRESENTATION:

1 x 25 mL (4 dose)

5 x 5 mL (1 dose)

DIN 00803472

Manufactured in Holland for: INTERVET CANADA, 250 WATER STREET, WHITBY, ONTARIO L1N 9T5

092052A 0042.570.2610

Nac No.