Oxstrin

This page contains information on Oxstrin for veterinary use.
The information provided typically includes the following:
  • Oxstrin Indications
  • Warnings and cautions for Oxstrin
  • Direction and dosage information for Oxstrin

Oxstrin

This treatment applies to the following species:
Manufacturer: Nutramax

Palatable Scored Tablets For Dogs

Sold only through veterinarians

Oxstrin, a veterinary exclusive product for dogs, is comprised of a melon extract that is complexed with wheat gluten. This product has been formulated to contain 400 IU of superoxide dismutase activity, which is protected from gastric degradation by a gluten complex, in each scored tablet.

Background

Superoxide Dismutase (SOD) is an enzyme found in oxygen utilizing organisms. SOD converts a reactive oxygen species (ROS), the superoxide anion, into molecular oxygen and hydrogen peroxide.1,2 Superoxide and nitric oxide, an important regulatory free radical, react very rapidly to form peroxynitrite, a highly damaging reactive nitrogen species (RNS).2 Therefore this “dismutation” of the superoxide ion reduces not only the level of superoxide, which alone can adversely affect biological molecules, but also helps maintain nitric oxide at physiological levels at which it regulates cells (e.g. smooth muscle)3 and reduces formation of peroxynitrite. Hydrogen peroxide and its derivative ROS can also adversely affect cell membranes, proteins, and DNA. To avoid these effects, it is further reduced to water and molecular oxygen by the enzymes catalase and glutathione peroxidase.2,4 These and other enzymes comprise a group of antioxidants that act as enzymatic antioxidants.

Purpose

The purpose of supplementation with Oxstrin is to “up-regulate” endogenous enzymatic antioxidants and to help manage oxidant/antioxidant imbalances, which cause oxidative stress.5,6 Excessive reactive oxygen species and oxidative stress cause increased lipid peroxidation in dogs.7 Oxstrin contains SOD that has been complexed with wheat gluten, protecting the SOD from gastric degradation and also playing a role in uptake of the SOD complex by the intestinal tract.3,8 Oral administration of the SOD complex found in Oxstrin over a 4 week period to mice9 and dogs10 elicited an increase in circulating SOD, catalase, and glutathione peroxidase levels. These increases in the three enzymatic antioxidants improved the ability of hepatocytes in mice to withstand oxidative stress.9 The SOD complex in Oxstrin was shown to reduce oxidative stress associated with a compromised renal condition of mice.11 Superoxide dismutase up-regulation may also benefit dogs in ameliorating oxidative stress involved in conditions of ischemia/reperfusion,12-14 gingival health,15 parasitic conditions,16 hepatic health,17 brain health,18 and eye health.19

Safety

In acute and chronic toxicity studies no abnormal clinical signs were observed in rats receiving Oxstrin's active ingredient. In the chronic toxicity study rats received up to 2000 mg/kg/day. No histopathologic changes were observed in any tissues for the groups receiving the SOD complex compared to controls. Clinical trials in dogs have not reported any side effects from receiving Oxstrin.

Ingredients

Melon extract*, maltodextrin, dicalcium phosphate, natural chicken flavor, wheat gluten, silicon dioxide, and magnesium stearate.

*Contains a wheat gluten complex that protects superoxide dismutase from gastric degradation

Each tablet standardized to contain 400 IU superoxide dismutase.

Administration

Oxstrin™ is formulated in a tasty chewable tablet that may be given as a treat or with food. Tablets are scored for ease of administration. Recommended administration amounts are provided below.

DAILY ADMINISTRATION GUIDE

Body Weight

Oxstrin tablet

<44 lbs.

1/2 tablet

≥44 lbs.

1 tablet

VETERINARIANS: for additional information about Oxstrin go to: www.nutramaxlabs.com and register at MyVetPort.

Storage

Store in a cool, dry area. Keep lid tightly secured to ensure freshness. Keep bottle out of the reach of children.

This bottle contains (1) non-toxic desiccant to help preserve freshness and ensure the shelf life of the product.

References

1 Bradford, R., Allen, HW. (1997) Oxidology, 2nd Ed., Robert W Bradford Foundation, Chula Vista, California

2 Halliwell, B., Gutteridge, JM. (1999) Free radicals in biology and medicine, third Ed., Oxford University Press, Oxford, UK

3 Jung, O., Marklund, S. L., Geiger, H., Pedrazzini, T., Busse, R., and Brandes, R. P. (2003) Circ Res 93(7), 622-629

4 Center, S. (2004) Veterinary Clinics of North America 34, 67-172

5 McCord, J. M. (1993) Clin Biochem 26(5), 351-357

6 McCord, J. M., and Edeas, M. A. (2005) Biomed Pharmacother 59(4), 139-142

7 Freeman, L. M., Rush, J. E., Milbury, P. E., and Blumberg, J. B. (2005) J Vet Intem Med 19(4), 537-541

8 Vouldoukis, I., Lacan, D., Kamate, C., Coste, P, Calenda, A., Mazier, D., Conti, M., and Dugas. B. (2004) J Ethnopharmacol 94(1), 67-75

9 Vouldoukis, I., Conti, M., Krauss, P., Kamate, C., Blazquez, S., Tefit, M., Mazier, D., Calenda, A., and Dugas, B. (2004) Phytother Res 18(12), 957-962

10 Data on file.

11 Naito, Y., Akagiri, S., Uchiyama, K., Kokura, S., Yoshida, N., Hasegawa, G., Nakamura, N., Ichikawa, H., Toyokuni, S., Ijichi,T., andYoshikawa, T. (2005) Biofactors 23(2). 85-95

12 Ogura, Y., Takagi. K., Kawarada, Y., and Mizumoto, R. (1996) J Gastroenterol 31(3), 379-386

13 Kapoor, R., Kalra, J., and Prasad, K. (1997) Mol Cell Biochem 176(1-2), 291-301

14 Omar, B. A., Flores, S. C., and McCord, J. M. (1992) Adv Pharmacol 23, 109-161

15 Sakallioglu, U., Aliyev, E., Eren, Z., Aksimsek, G., Keskiner, I., and Yavuz, U. (2005) Arch Oral Biol 50(12), 1040-1046

16 Vouldoukis, I., Drapier, J. C., Nussler, A. K., Tselentis, Y., Da Silva, O.A., Gentilini, M., Mossalayi, D. M., Monjour, L., and Dugas. B. (1996) Antimicrob Agents Chemother 40(1), 253-256

17 Sato. R., Inanami, O., Syuto, B., Sato, J., Kuwabara. M., and Naito, Y. (2003) J Vet Med Sci 65(4), 465-469

18 Siwak, C. T., Tapp, P. D., Head, E., Zicker, S. C., Murphey. H. L., Muggenburg, B. A., Ikeda-Douglas, C. J., Colman, C. W., and Milgram, N. W. (2005) Prog Neuropsychopharmacol Biol Psychiatry 29(3). 461-469

19 Barros, P. S., Safatle, A. M., Queiroz, L., Silva, V. V., and Barros, S. B. (2004) Can J Ophthalmol 39(1), 19-24

Nutramax Laboratories, Inc., 2208 Lakeside Boulevard, Edgewood, Maryland 21040

1-800-925-5187

nutramaxlabs.com

02-1008-00

30 Chewable Tablets

00-1039-00

Nac No.

12910140
NUTRAMAX LABORATORIES, INC.
2208 LAKESIDE BLVD., EDGEWOOD, MD, 21040
Telephone:   410-776-4000
Toll-Free:   800-925-5187
Fax:   410-776-4009
Website:   www.nutramaxlabs.com
Every effort has been made to ensure the accuracy of the Oxstrin information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Oxstrin product label or package insert.

Copyright © 2014 North American Compendiums. Updated: 2014-05-28

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