NuflorGOLD

This page contains information on NuflorGOLD for veterinary use.
The information provided typically includes the following:
  • NuflorGOLD Indications
  • Warnings and cautions for NuflorGOLD
  • Direction and dosage information for NuflorGOLD

NuflorGOLD

This treatment applies to the following species:
Manufacturer: Intervet/Merck Animal Health

(florfenicol)

NADA 141-265, Approved by FDA.

Injectable Solution, An Antimicrobial

300 mg/mL

For subcutaneous use in beef and non-lactating dairy cattle only

Not for use in female dairy cattle 20 months of age or older or in calves to be processed for veal

NuflorGOLD Caution

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Description

NUFLOR GOLD™ is an injectable solution of the synthetic antibiotic florfenicol. Each milliliter of sterile NUFLOR GOLD™ contains 300 mg of florfenicol, 300 mg of 2-pyrrolidone, and triacetin qs.

NuflorGOLD Indications

NUFLOR GOLD™ is indicated for treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis in beef and non-lactating dairy cattle.

Dosage and Administration

NUFLOR GOLD™ should be administered once by subcutaneous injection at a dose rate of 40 mg florfenicol/kg body weight (6 mL/100 lb). Do not administer more than 15 mL at each site. The injection should be given only in the neck. Injection sites other than the neck have not been evaluated.

NUFLOR GOLD™ Dosage Guide

ANIMAL WEIGHT

(lb)

DOSAGE
(mL)

100

6.0

200

12.0

300

18.0

400

24.0

500

30.0

600

36.0

700

42.0

800

48.0

900

54.0

1000

60.0

Recommended Injection Location:

Contraindications

Do not use in animals that have shown hypersensitivity to florfenicol.

WARNINGS: NOT FOR HUMAN USE. KEEP OUT OF REACH OF CHILDREN. This product contains materials that can be irritating to skin and eyes. Avoid direct contact with skin, eyes, and clothing. In case of accidental eye exposure, flush with water for 15 minutes. In case of accidental skin exposure, wash with soap and water. Remove contaminated clothing. Consult a physician if irritation persists. Accidental injection of this product may cause local irritation. Consult a physician immediately. The Material Safety Data Sheet (MSDS) contains more detailed occupational safety information.

For customer service, to report suspected adverse reactions, or to obtain a copy of the MSDS, call 1-800-211-3573.

Precautions

Not for use in animals intended for breeding purposes. The effects of florfenicol on bovine reproductive performance, pregnancy, and lactation have not been determined. Toxicity studies in dogs, rats, and mice have associated the use of florfenicol with testicular degeneration and atrophy.

Subcutaneous injection in cattle can cause a transient local tissue reaction that may result in trim loss of edible tissue at slaughter.

RESIDUE WARNINGS: Animals intended for human consumption must not be slaughtered within 44 days of treatment. Do not use in female dairy cattle 20 months of age or older. Use of florfenicol in this class of cattle may cause milk residues. A withdrawal period has not been established in pre-ruminating calves. Do not use in calves to be processed for veal.

Adverse Reactions

Transient inappetence, diarrhea, decreased water consumption, and injection site swelling have been associated with the use of florfenicol in cattle. In addition, anaphylaxis and collapse have been reported post-approval with the use of another formulation of florfenicol in cattle.

Clinical Pharmacology

The pharmacokinetic disposition of NUFLOR GOLD™ was evaluated in feeder calves following single subcutaneous injection at a dose rate of 40 mg florfenicol/kg body weight. Administration of NUFLOR GOLD™ resulted in florfenicol plasma concentrations of 2 µg (mcg)/mL within two hours of injection.

Table 1. Pharmacokinetic Parameter Values for Florfenicol Following a Single Subcutaneous Injection of NUFLOR GOLD™ at a Dose Rate of 40 mg Florfenicol/kg Body Weight to Feeder Calves (n=24).

 

Cmax
(µg/mL)

Tmax
(hr)

AUClast
(µg*hr/mL)

T1/2
(hr)

n

24

24

24

232

Mean

5.93

51

150

37.7

% CV

38.3

2-121

20.9

27.3

Cmax: Maximum observed plasma concentration

Tmax: Time at which Cmax is observed

AUClast: Area under the plasma-concentration-time curve from time zero to the last quantifiable concentration that is equal to or greater than the limit of quantification of the validated analytical method

T1/2: Terminal elimination half-life

% CV: Percent coefficient of variance

1 Tmax is presented as the median value or range of observed values (minimum to maximum)

2 T1/2 value could not be accurately estimated for one calf

Figure 1. Mean Florfenicol Plasma Concentration versus Time Following a Single Subcutaneous Injection of NUFLOR GOLD™ at a Dose Rate of 40 mg Florfenicol/kg Body Weight in Feeder Calves (Mean ± Standard Error of the Mean)

MICROBIOLOGY: Florfenicol is a synthetic, broad-spectrum antibiotic active against many Gram-negative and Gram-positive bacteria isolated from domestic animals. It acts by binding to the 50S ribosomal subunit and inhibiting bacterial protein synthesis. Florfenicol is generally considered a bacteriostatic drug, but it exhibits bactericidal activity against certain bacterial species. In vitro studies demonstrate that florfenicol is active against the BRD pathogens M. haemolytica, P. multocida, H. somni, and M. bovis and that florfenicol exhibits bactericidal activity against strains of M. haemolytica and H. somni.

The minimum inhibitory concentrations (MICs) of florfenicol were determined for BRD isolates obtained from calves enrolled in BRD field studies in the U.S. in 2006 using methods recommended by the Clinical and Laboratory Standards Institute (M31-A2)1. Isolates were obtained from pre-treatment nasal swabs from all calves enrolled at all four sites, post-treatment nasal swabs from treatment failures in the NUFLOR GOLD Injectable Solution and saline control treatment groups at three sites, and lung tissue from one calf that died in the saline control treatment group. The results are shown below in Table 2.

Table 2. Florfenicol MIC values* of indicated pathogens isolated from cattle with naturally-occurring BRD

Indicated pathogens

Year of isolation

No. of isolates

MIC50**
(µg/mL)

MIC90**
(µg/mL)

MIC range
(µg/mL)

Mannheimia haemolytica

2006

158

1.0

1.0

0.5 to 32

Pasteurella multocida

2006

103

0.5

0.5

≤ 0.125 to 16

Histophilus somni

2006

85

≤ 0.125

≤ 0.125

≤ 0.125 to 0.25

Mycoplasma bovis

2006

59

1.0

1.0

0.5 to 1.0

* The correlation between in vitro susceptibility data and clinical effectiveness is unknown.

** The lowest MIC to encompass 50% and 90% of the most susceptible isolates, respectively.

1 CLSI methods for M. bovis MIC determination have not been established.

The reproducibility of the method used was confirmed in 3 independent microbiology laboratories.

ANIMAL SAFETY: A target animal safety study was conducted to evaluate the effects of NUFLOR GOLD™ when administered to feeder cattle by subcutaneous injection at 1X, 3X, or 5X the labeled dose for three consecutive days (3X the labeled duration). Decreased feed consumption (inappetence), decreased water consumption, and injection site swelling were observed in the 1X, 3X, and 5X groups.

A separate injection site study conducted in cattle demonstrated that NUFLOR GOLD™ may induce a transient local reaction in the subcutaneous tissue and underlying muscle tissue.

STORAGE INFORMATION: Store between 2°-30°C (36°-86°F). Use within 28 days of first use. Refrigeration is not required. The solution is light yellow to straw colored. Color does not affect potency.

How Supplied

NUFLOR GOLD™ is packaged in 100 mL (NDC 0061-5327-01), 250 mL (NDC 0061-5327-02), and 500 mL (NDC 0061-5327-03) glass sterile multiple-dose vials.

Made in Germany

Intervet Inc., Roseland, NJ 07068

© 2009, Intervet Inc.

All rights reserved.

Rev. 9/09

US 3313_1 R

US 3313_1 V

NAC No.: 10472971

MERCK ANIMAL HEALTH
Intervet Inc.

556 MORRIS AVE., SUMMIT, NJ, 07901
Customer Service:   800-521-5767
Order Desk:   800-648-2118
Technical Service (Companion Animal):   800-224-5318
Technical Service (Livestock):   800-211-3573
Fax:   908-473-5560
Website:   www.merck-animal-health-usa.com
Every effort has been made to ensure the accuracy of the NuflorGOLD information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2014 North American Compendiums. Updated: 2014-12-03

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