Noromectin Pour-On (Canada)

This page contains information on Noromectin Pour-On for veterinary use.
The information provided typically includes the following:
  • Noromectin Pour-On Indications
  • Warnings and cautions for Noromectin Pour-On
  • Direction and dosage information for Noromectin Pour-On

Noromectin Pour-On

This treatment applies to the following species:
Manufacturer: Kane Veterinary Supplies

(ivermectin)

for cattle

FOR VETERINARY USE ONLY

DIN 02248033

Active Ingredient

Each mL contains 5 mg of ivermectin

Net contents:

(1 L), (2.5 L), (5 L) or (20 L)

For the treatment of parasitic infections and infestations due to gastrointestinal roundworms, eyeworms, lungworms, grubs, sucking and biting lice, mites and hornflies in cattle.

Introduction

Noromectin Pour-On contains ivermectin, a unique chemical entity. Its convenience, broad-spectrum efficacy and wide safety margin make it an excellent antiparasitic product for cattle. One dose effectively controls a wide range of internal and external parasites that can impair the health and productivity of cattle.

Product Description

Noromectin Pour-On for cattle is a clear, blue coloured liquid containing 5 mg of ivermectin per mL (0.5% w/v). Noromectin Pour-On is formulated to deliver the recommended dose level of 500 µg of ivermectin per kg of body weight in cattle when applied along the top line from the withers to the tail head at the rate of 1 mL per 10 kg.

Active Ingredient

Ivermectin is an antiparasitic agent derived from the avermectin family of compounds. The avermectins are highly active, broad-spectrum antiparasitic agents isolated from fermentation of the soil organism Streptomyces avermitilis.

Noromectin Pour-On Indications

Noromectin Pour-On applied at the recommended dose level of 500 µg of ivermectin per kg of body weight is indicated for the treatment of parasitic infections and infestations due to gastrointestinal roundworms, eyeworms, lungworms, grubs, sucking and biting lice, mites and hornflies in cattle. In addition, due to its persistent effect, this product also controls certain parasitic infections and infestations as outlined in the enclosed package insert under PERSISTENT EFFECT.

Following is a complete list of the parasites against which efficacy has been demonstrated:

Gastrointestinal roundworms

Ostertagia ostertagi, adults and fourth stage larvae including inhibited O. ostertagi; Haemonchus placei, adults and fourth stage larvae; Trichostrongylus axei, adults and fourth stage larvae; T. colubriformis, adults and fourth stage larvae; Cooperia surnabada (syn. mcmasteri), adults; C. oncophora, adults; C. punctata, adults; Nematodirus helvetianus, fourth stage larvae; Oesophagostomum radiatum, adults and fourth stage larvae; O. venulosum, adults; Trichuris ovis, adults; Strongyloides papillosus, adults

Eye worms - Thelazia gulosa, adults; T. skrjabini, adults

Mange mites - Chorioptes bovis; Sarcoptes scabiei var bovis (if psoroptic mange is to be treated, Noromectin Injection for cattle and swine is recommended).

Lungworms - Dictyocaulus viviparus, adults and fourth stage larvae.

Cattle grubs (internal parasitic stages) - Hypoderma bovis; H. lineatum

Lice - Linognathus vituli; Haematopinus eurysternus; Damalinia (syn. Bovicola) bovis

Horn flies - Haematobia irritans

Persistent Effect

Endoparasites

Noromectin Pour-On given at the recommended dosage of 500 µg of ivermectin per kg of body weight effectively controls infections of Dictyocaulus viviparus and Oesophagostomum radiatum acquired up to 28 days after treatment; Trichostrongylus axei and Cooperia punctata acquired up to 21 days after treatment; and Haemonchus placei, Ostertagia ostertagi, Cooperia oncophora and Cooperia surnabada (syn. mcmasteri) acquired up to 14 days after treatment.

Ectoparasites

Noromectin Pour-On given at the recommended dosage of 500 µg of ivermectin per kg of body weight effectively controls infestations of Haematobia irritans acquired up to 35 days after treatment; Damalinia (Bovicola) bovis acquired up to 55 days after treatment and Linognathus vituli acquired up to 49 days after treatment.

Note to user - For best results, Noromectin Pour-On should be part of a total parasite control program including internal and external parasites based on the epidemiology of these parasites. Consult a veterinarian or entomologist for the most effective timing of applications.

Noromectin Pour-On Dosage And Administration

Noromectin Pour-On is formulated for external use only in cattle; it should not be used in other species. The formulation should be applied along the top-line in a narrow strip extending from the withers to the tail head at a dose rate of 1 mL per 10 kg of body weight.

Squeeze-Measure-Pour System (1 L bottle with 50 mL Metering Cup):

Attach the metering cup to the bottle.

Set the dose by turning the top section of the cup, aligning the correct body weight with the pointer on the knurled cap. When body weight is between the markings, use the higher setting.

Hold the bottle upright and squeeze it to deliver a slight excess of the required dose as indicated by the calibration lines.

By releasing the pressure, the dose automatically adjusts to the correct level. Tilt the bottle to dispense the dose. When 100 kg (10 mL) or 150 kg (15 mL) dose is required, turn the pointer to “stop” before dispensing the dose. The off (stop) position will close the system. Bottles should remain upright during storage.

Single/Twin Neck Dispenser System (1 L bottle)

Hold the bottle upright and squeeze it to deliver the required dose as indicated by the calibration lines.

Collapsible Packs (2.5 L and 5 L)

Use dosing equipment compatible with Noromectin Pour-On. Follow manufacturer’s directions for use and care of the equipment. Other dosing equipment may be incompatible resulting in locking, incorrect dosage and leakage. Connect the dosing gun to the collapsible pack as follows:

1 Attach the open end of the draw-off tubing to the dosing gun and attach draw off tubing to the self-venting cap with the stem.

2 Replace the shipping cap with the self-venting draw-off cap which has the stem and tighten this cap.

3 Invert the pack and gently prime the dosing gun, checking for leaks.

Container (20 L)

Use dosing equipment compatible with Noromectin Pour-On. Follow manufacturer’s directions for use and care of the equipment. Other dosing equipment may be incompatible resulting in locking, incorrect dosage and leakage. Connect the dosing gun to the container as follows:

1 Attach the open end of the draw-off tubing to the dosing gun and attach draw off tubing to the self-venting cap with the stem.

2 Replace the shipping cap with the self-venting draw-off cap which has the stem and tighten this cap.

3 Invert the pack and gently prime the dosing gun, checking for leaks.

Mode Of Action

Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).

The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated channels and they do not readily cross the blood-brain barrier.

Note To User

The colour of Noromectin Pour-On fades when exposed to light and depending upon the light intensity, fading may occur in less than 30 minutes. The rapid loss of colour does not reflect loss of potency of ivermectin. However, prolonged exposure (i.e. weeks) to light can also result in a gradual decline of ivermectin potency in the formulation.

Safety

Studies have demonstrated a wide safety margin. Based on plasma levels, the topically applied formulation is expected to be at least as well tolerated by breeding animals as is the subcutaneous formulation, which has demonstrated an adequate safety margin in breeding animals.

Environmental Safety

Studies indicate that when ivermectin comes in contact with the soil, it readily and tightly binds to the soil and becomes inactive over time. Drug containers and any residual contents should be disposed of safely (e.g. by burying or incinerating) as free ivermectin may adversely affect fish or certain water-borne organisms.

WARNING

1 Treated animals must not be slaughtered for use in food for at least forty-nine (49) days after the last treatment with this drug.

2 A withholding time for milk has not been established. Therefore, non-lactating dairy cows must not be treated within two (2) months of calving.

3 This product may be irritating to human skin and eyes. If accidental skin contact occurs, wash the affected area immediately with soap and water. If accidental eye exposure occurs, flush eyes immediately with water and contact a physician.

4 Keep this and all drugs out of the reach of children.

Noromectin Pour-On Caution

1 For topical application only. Do not administer orally or parenterally.

2 This product is not for use in species other than cattle.

3 Cattle should not be treated when hair or hide is wet since reduced efficacy will be experienced. Rain falling on cattle in less than 2 hours after dosing may result in reduced efficacy.

4 The antiparasitic activity of ivermectin will be impaired if the formulation is applied to areas of skin with mange scabs or lesions, or with dermatoses or adherent materials, e.g., caked mud or manure.

5 To prevent potential secondary reactions when treating infections with cattle grubs, consult your veterinarian on the correct timing of treatment.

Storage

Store below 25°C away from heat.

Noromectin Pour-On stored at temperatures below 0°C may become cloudy. Warming at room temperature will restore the normal appearance without affecting efficacy.

Store the bottle in the carton to protect from light.

Flammable: keep away from heat, sparks, open flame, or other sources of ignition.

Packaging Information

Noromectin Pour-On for cattle is available in four ready to use sizes: 1 L, 2.5 L, 5 L and 20 L.

1 L: is supplied in a multiple-dose bottle. Each pack contains enough solution to treat 40 x 250 kg of body weight.

2.5 L: is supplied in a soft, collapsible pack. Each pack contains enough solution to treat 100 x 250 kg of body weight.

5 L: is supplied in a soft, collapsible pack. Each pack contains enough solution to treat 200 x 250 kg of body weight.

20 L: is supplied in a container. Each pack contains enough solution to treat 800 x 250 kg of body weight.

Manufactured by: Norbrook Laboratories Limited, Newry, Co. Down, Northern Ireland

Distributed by: Kane Veterinary Supplies Ltd., 11204 - 186 Street, Edmonton AB T5S 2W2

016154I07

NAC No.: 12540030

KANE VETERINARY SUPPLIES LTD.
11204-186TH STREET, EDMONTON, AB, T5S 2W2
Telephone:   780-453-1516
Telephone (Cambridge):   519-740-0733
Order Desk:   800-361-3232
Fax:   780-455-9874
Fax (Cambridge):   519-740-6419
Website:   www.kanevet.com
Every effort has been made to ensure the accuracy of the Noromectin Pour-On information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2014 North American Compendiums. Updated: 2014-12-03

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