Noromectin Injection for Cattle and Swine (Canada)

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  • Noromectin Injection for Cattle and Swine Indications
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Noromectin Injection for Cattle and Swine

This treatment applies to the following species:
Manufacturer: Kane Veterinary Supplies

(ivermectin)

FOR VETERINARY USE ONLY

DIN: 02247349

For the treatment of infections and infestations due to internal and external parasites in cattle and swine.

Introduction

Noromectin contains ivermectin, a unique chemical entity. Its convenience, broad-spectrum efficacy and wide safety margin make it an excellent antiparasitic product for cattle and swine. One low-volume dose effectively controls internal and external parasites of cattle and swine that can impair health and productivity.

Product Description

Noromectin Injection is a ready-to-use sterile solution containing the following ingredients per mL: 10 mg ivermectin, 0.40 mL glycerol formal and polyethylene glycol q.s. ad 1 mL. Noromectin Injection is formulated to deliver the recommended dose level of 200 μg ivermectin per kg of bodyweight in cattle when given subcutaneously at the rate of 1 mL per 50 kg. In swine, Noromectin Injection is formulated to deliver the recommended dose level of 300 μg ivermectin per kg bodyweight when given subcutaneously at the rate of 1 mL per 33 kg. Studies show that Noromectin Injection is stable for two years when stored under normal conditions.

Noromectin Injection for Cattle and Swine Indications

Cattle

Noromectin Injection is indicated for the treatment of infections and infestations due to gastrointestinal roundworms, lungworms, grubs, sucking lice and mange mites in cattle:

Gastrointestinal Roundworms*: Ostertagia ostertagi (adults and fourth stage larvae including inhibited O. ostertagi); O. lyrata (adults); Haemonchus placei (adults and fourth stage larvae); Trichostrongylus axei (adults and fourth stage larvae); T. colubriformis (adults); Cooperia oncophora (adults and fourth stage larvae); C. punctata (adults); Oesophagostomum radiatum (adults and fourth stage larvae); Strongyloides papillosus (adults).

Eye Worms: Thelazia spp.

Lungworms*: Dictyocaulus viviparus (adults and fourth stage larvae).

Cattle grubs (internal parasitic stages): Hypoderma bovis; H. lineatum.

Sucking lice: Linognathus vituli; Haematopinus eurysternus; Solenopotes capillatus

Mites: Sarcoptes scabiei var bovis; Psoroptes ovis (syn. P. communis var bovis)

*Noromectin Injection given at the recommended dosage controls infections of Dictyocaulus viviparus, Ostertagia ostertagi and Oesophagostomum radiatum for 21 days after treatment; Haemonchus placei, Trichostrongylus axei, Cooperia punctata and Cooperia oncophora for 14 days after treatment.

Swine

Noromectin Injection is indicated for the treatment of the following parasitic infections and infestations in swine:

Gastrointestinal roundworms: large roundworms, Ascaris suum (adults and L4); Red stomach worm, Hyostrongylus rubidus (adults and L4); Nodular worm, Oesophagostomum spp (adults and L4); Threadworm, Strongyloides ransomi (adults and somatic larvae).

Somatic Threadworm Larvae (Strongyloides ransomi). Sows must be treated at least seven days before farrowing to prevent infection of piglets.

Lungworm: Metastrongylus spp (adults).

Lice: Haematopinus suis.

Mites: Sarcoptes scabiei var suis.

Noromectin Injection for Cattle and Swine Dosage And Administration

Cattle

Noromectin Injection should be given only by subcutaneous injection at the recommended dosage level of 200 μg of ivermectin per kg of bodyweight. Each mL contains 10 mg of ivermectin, sufficient to treat 50 kg of bodyweight (maximum 10 mL per injection site).

Noromectin Injection should be given subcutaneously only. Inject under the loose skin in front of or behind the shoulder. Use of a 16 gauge, 15 to 20 mm (3/4 inch) needle is suggested. Use sterile equipment.

Swine

The recommended dose level is 1 mL of Noromectin Injection per 33 kg bodyweight (300 μg of ivermectin per kg of bodyweight). The recommended route of administration is by subcutaneous injection in the neck. The solution may be given with any standard automatic or single-dose equipment. In young pigs, especially those below 16 kg for which less than 0.5 mL of Noromectin Injection is indicated, dosing accuracy is important. The use of a syringe that can accurately deliver as little as 0.1 mL is recommended. Use aseptic technique.

Recommended Treatment Program

I. Breeding Animals

At the time of initiating any parasite control program it is important to treat all breeding animals in the herd. After the initial treatment, use Noromectin Injection regularly as follows:

Sows

Treat prior to farrowing, preferably 7-14 days before, to minimise infection of piglets.

Gilts

Treat 7-14 days prior to breeding. Treat 7-14 days prior to farrowing.

Boars

Frequency and need for treatments are dependent upon exposure. Treat at least two times per year.

Ii. Feeder Pigs

All feeder pigs should be treated before placement in clean quarters. Pigs exposed to contaminated soil or premises may need retreatment if reinfection occurs.

Note:

1. Noromectin Injection has a persistent drug level sufficient to control mite infestations throughout the egg to adult life cycle. However, since the ivermectin effect is not immediate, care must be taken to prevent reinfestation from exposure to untreated animals or contaminated facilities. Generally, pigs should not be moved to clean quarters or exposed to uninfested pigs for approximately one week after treatment. Sows should be treated at least one week before farrowing to minimise transfer of mites to newborn baby pigs.

2. Louse eggs are unaffected by Noromectin Injection and may require up to three weeks to hatch. Louse infestations developing from hatching eggs may require retreatment.

3. Consult a veterinarian for aid in the diagnosis and control of internal and external parasites of swine.

Mode Of Action

Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).

The margin of safety for compounds of this class is attributable to the fact that mammals do not have glumate-gated chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.

Clinical Advantages

Injectable Convenience

Noromectin Injection is an injectable antiparasitic agent highly effective against both internal and external parasites of cattle and swine in Canada. It can be administered quickly and easily.

Broad Spectrum

Noromectin Injection provides broad-spectrum efficacy against gastrointestinal roundworms, lungworms, cattle grubs, and sucking lice and mange mites of cattle and swine with one easy to give injection (see complete list of parasites).

Unique Chemical Compound

Noromectin Injection contains ivermectin, a unique antiparasitic compound.

Safety

Noromectin Injection has demonstrated a wide safety margin at the recommended dose level in cattle and swine. Noromectin Injection may be used in breeding animals.

Stability

Noromectin Injection has been shown to be stable for two years when stored under normal conditions.

WARNING

1. Treated cattle must not be slaughtered for use in food for at least thirty-five (35) days after the last treatment with this drug; treated swine must not be slaughtered for use in food for at least twenty-eight (28) days after the last treatment with this drug.

2. Non-lactating dairy cattle must not be treated with this drug for at least two (2) months prior to calving.

3. Not for use in lactating dairy cattle.

4. Keep this and all drugs out of the reach of children.

Noromectin Injection for Cattle and Swine Caution

1. Do not administer intravenously or intramuscularly.

2. Transitory discomfort has been observed in some animals following subcutaneous administration. A low incidence of soft tissue swelling at the injection site has been observed. These reactions have disappeared without treatment. Divide doses greater than 10 mL between injection sites to reduce occasional discomfort to site reaction. Different sites should be used for other parenteral products.

3. Cattle - To prevent potential secondary reactions when treating infections with cattle grubs, consult your veterinarian on the correct timing of treatment.

Environmental Safety

Studies indicate that when ivermectin comes in contact with the soil, it readily and tightly binds to the soil and becomes inactive. Drug containers and any residual contents should be disposed of safely (e.g. by burying or incinerating) as free ivermectin may adversely affect fish and certain water-borne organisms.

Storage

Store the bottle in the carton to protect from light.

Packaging

Noromectin Injection for Cattle and Swine is available in five ready to use sizes: 50 mL, 100 mL, 250 mL, 500 mL and 1000 mL.

50 mL is supplied in a multiple-dose, rubber-capped bottle.

100 mL is supplied in a multiple-dose, rubber-capped bottle.

250 mL is contained in a multiple-dose, rubber-capped bottle designed for use with automatic injection equipment.

500 mL is contained in a multiple-dose, rubber-capped bottle designed for use with automatic injection equipment.

1000 mL is contained in a multiple-dose, rubber-capped bottle designed for use with automatic injection equipment.

MANUFACTURED BY Norbrook Laboratories Limited, Newry, Co. Down, Northern Ireland

DISTRIBUTED BY Kane Veterinary Supplies Ltd., 11204 - 186 Street, Edmonton, AB T5S 2W2

002154I04

NAC No.: 12540020

KANE VETERINARY SUPPLIES LTD.
11204-186TH STREET, EDMONTON, AB, T5S 2W2
Telephone:   780-453-1516
Telephone (Cambridge):   519-740-0733
Order Desk:   800-361-3232
Fax:   780-455-9874
Fax (Cambridge):   519-740-6419
Website:   www.kanevet.com
Every effort has been made to ensure the accuracy of the Noromectin Injection for Cattle and Swine information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2014 North American Compendiums. Updated: 2014-09-05

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