Neosol Drops (Canada)

Manufacturer: Vétoquinol

Neomycin and Methscopolamine Bromide Drops

DIN 00555495

Veterinary Use Only

Active Ingredients

Each mL contains 50 mg of Neomycin Sulfate (equivalent to 35 mg Neomycin base) and 0.25 mg of Methscopolamine Bromide.

Actions

Since the antibacterial effect of orally administered Neomycin is not diverted from the gut by absorption or inactivated by gastrointestinal secretion, bacteria, or enzymes, Neomycin is therapeutically effective in gastrointestinal infections in lower concentrations than orally administered, absorbable, systemic antibacterial agents. Neomycin is a wide spectrum antibiotic derived from Streptomyces fradiae.

Neomycin sulfate is effective in vitro against Staphylococcus aureus, haemolytic streptococci, Pasteurella multocida, Escherichia coli, Klebsiella, Enterobacter aerogenes, and other gram-positive and gram-negative bacteria. Microorganisms do not readily develop resistance to Neomycin. Recently, resistance to Neomycin has been reported more frequently than in the past. Neomycin possesses no known anti-protozoal, antifungal or anti-viral action.

Methscopolamine bromide is an anticholinergic (parasympatholytic) agent with high selectivity or inhibitory action on the segment of the parasympathetic system concerned with the gastrointestinal tract. It reduces the secretions and the motility of the gastrointestinal tract. It also delays gastric emptying and inhibits salivary secretions and sweating. Subcutaneous injection to rats of a dose 2400 times greater than the effective antisecretory dose given intravenously produced little or no stimulation of the central nervous system. Ganglionic and myoneural blocking action in animals were manifest only with very high doses.

Neosol Drops Indications

As an aid in the treatment of bacterial diarrhea and gastrointestinal infections of dogs and cats, especially when accompanied by hypermotility and hypersecretion. It is useful and effective in treating epizootic outbreaks of infectious diarrhea caused by organisms sensitive to Neomycin. Neosol Drops is also of value as an aid in preventing enteric infections in animals known to be exposed or susceptible to organisms sensitive to Neomycin.

Dosage & Administration

The recommended dosage for treatment of bacterial enteritis and diarrhea in dogs and cats is 5 mg (0.1 mL) Neomycin sulfate per 0.45 kg (1 lbs) of body weight, per day, in divided doses, every 12 hours for a duration recommended by your veterinarian. This dosage level is attained by the use of 0.5 mL of Neosol Drops per 4.54kg (10 lbs) of body weight given orally twice daily. The daily dosage may be measured as follows, using the enclosed calibrated dropper.

Total Body Weight	Dosage
2.0 kg	0.25 mL Twice a day
4.5 kg	0.50 mL Twice a day
9.0 kg	1.00 mL Twice a day

If symptoms persist after using this product for 2 to 3 days, the diagnosis should be revised.

Neosol Drops Has The Following Advantages In Treating Gastrointestinal Infections:

1. May Be Given Individually To Animals Or May Be Added To The Milk Or Feed. neosol Drops Is Palatable.

2. Wide Spectrum Effect Against Many Enteric Bacterial Infections.

3. Bactericidal In Low Concentrations Against Many Intestinal Pathogens; Does Not Favor Development Of Resistant Strains.

4. Antibacterial Action Restricted To And Concentrated In The Gut.

5. Fully Active In Presence Of Gastrointestinal Contents.

6. Nontoxic And Nonirritating To Sensitive Tissues.

7. Allows Intake Of Food And Fluids.

8. Profound Anticholinergic Effects.

9. Reduces Hypermotility, Hypersecretion, And Hyperacidity Of The Gut.

caution: Neosol Drops Is For Oral Use Only. Inasmuch As Neomycin Is Only Sparingly Absorbed From The Gastrointestinal Tract, The Antibacterial Action Of neosol Drops Is Concentrated Within The Gut And Does Not Provide Systemic Antibacterial Effect When Given Orally. Because Of Its Possible Mydriatic Effect, neosol Drops Should Not Be Given To Animals With Glaucoma. Because Of Its Action In Delaying Gastric Emptying, The Drug Should Be Used Cautiously, If At All, In The Presence Of Pyloric Obstruction. It Should Also Be Used With Caution In Animals With Prostatic Hypertrophy And Other Urinary Tract Obstruction.

adverse Reactions

Anticholinergic effects that have been reported occasionally are dryness of the mouth and tongue, increased water consumption, mydriasis, nausea, and mild constipation. These signs indicate the systemic activity of the Methscopolamine Bromide and are reversible on discontinuation of the drug.

Warning

Keep out of reach of children.

Storage Conditions

Store between 15 °C and 25 °C.

Vétoquinol N.-A. Inc., 2000, ch. Georges, Lavaltrie, QC, Canada J5T 3S5

992611

Net	Code
10 mL	992346	992609, 992610

Nac No.

12343130