Metricure (Canada)

This page contains information on Metricure for veterinary use.
The information provided typically includes the following:
  • Metricure Indications
  • Warnings and cautions for Metricure
  • Direction and dosage information for Metricure

Metricure

This treatment applies to the following species:
Manufacturer: Merck Animal Health

CEPHAPIRIN BENZATHINE UTERINE SUSPENSION

FOR VETERINARY USE ONLY

DIN 02237680

Sterile

DESCRIPTION

Each 19 gram syringe contains:

ACTIVE INGREDIENTS:

640 mg cephapirin benzathine

NON-MEDICINAL INGREDIENTS:

0.09 g cetomacrogol 1000 (emulsifier)

0.21 g eumulgin B1 (emulsifier)

0.15 g hydrogenated castor oil (stabilizer)

in fractionated coconut oil (vehicle)

THERAPEUTIC CLASSIFICATION

Antibiotic.

INDICATIONS

Metricure is an antibiotic indicated for the treatment of subacute and chronic endometritis in cows caused by Actinomyces (Corynebacterium) pyogenes, Fusobacterium necrophorum and pigment-forming Bacteroides strains.

To accurately diagnose subacute or chronic endometritis, a vaginoscopic examination should be done to confirm the presence of a discharge from the cervix.

DOSAGE AND ADMINISTRATION

Thoroughly clean the vulvar area, maintain aseptic conditions and avoid contaminating the catheter in preparation for the infusion.

Introduce a single dose of 640 mg of cephapirin benzathine (one 19 g syringe) into the lumen of the uterus using a disposable catheter. Fix the syringe to the catheter, then taking the cervix into a gloved hand introduced into the rectum; introduce the catheter through the cervix into the lumen of the uterus by gentle oscillating movements of the cervix. Inject the contents of the syringe.

One treatment is usually sufficient for a complete cure. If the quantity and quality of the cervical discharge is not improved at examination 14 days after treatment, the cow should receive a second treatment. Other contaminating organisms not sensitive to cephapirin may be the cause of the infection and accurate laboratory diagnosis may be necessary. In inseminated animals, Metricure can be used one day following insemination.

CAUTIONS

In case of anaphylactic reaction administer epinephrine.

WARNINGS

Treated animals must not be slaughtered for use in food for at least 48 hours after the latest treatment with this drug.

No milk withholding time is required when used according to the label.

Keep out of reach of children.

PHARMACOLOGY

Cephapirin, a first generation cephalosporin, is a broad spectrum antibiotic with bactericidal action against sensitive gram-positive bacteria and gram-negative anaerobic bacteria. It is resistant to the action of penicillinase and is active in an anaerobic environment as encountered in an infected uterus. After a single treatment with Metricure, concentrations of cephapirin in endometrial tissue above the MIC of sensitive bacteria are maintained for at least 24 hours.

The suspension is easily infused and is well tolerated, enabling good diffusion of cephapirin into the endometrium.

STORAGE

Store in a dry place between 15° and 25°C.

SUPPLY

Box of 10 x 19 g syringes, 10 catheters and 10 gloves.

Box of 12 x 19 g syringes.

Intervet Canada Corp, 16750, route Transcanadienne, Kirkland QC, H9H 4M7

1-888-306-0069

® Registered trademark of Intervet International B.V. Used under license.

Intervet Canada Corp. is a subsidiary of Merck & Co., Inc.

Version 07 June 2012

11-0152INS

106539 R6

NAC No.: 12081433

MERCK ANIMAL HEALTH
Intervet Canada Corp.

16750 ROUTE TRANSCANADIENNE, KIRKLAND, QC, H9H 4M7
Order Desk:   514-428-7013
Toll-Free:   866-683-7838
Fax:   Toll-free 888-498-4444; local 514-428-7014
Website:   www.merck-animal-health.ca
Every effort has been made to ensure the accuracy of the Metricure information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2014 North American Compendiums. Updated: 2014-05-28

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