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Marek's Disease Vaccine (Rispens CVI 988 Strain + HVT)

This page contains information on Marek's Disease Vaccine (Rispens CVI 988 Strain + HVT) for veterinary use.
The information provided typically includes the following:
  • Marek's Disease Vaccine (Rispens CVI 988 Strain + HVT) Indications
  • Warnings and cautions for Marek's Disease Vaccine (Rispens CVI 988 Strain + HVT)
  • Direction and dosage information for Marek's Disease Vaccine (Rispens CVI 988 Strain + HVT)

Marek's Disease Vaccine (Rispens CVI 988 Strain + HVT)

This treatment applies to the following species:
Manufacturer: Merial Select

Marek's Disease Vaccine, Live Chicken and Turkey Herpesvirus

U.S. Vet. Lic. No.: 279

Contents: This vaccine contains the Rispens CVI 988 strain of chicken herpesvirus and the FC-126 strain of turkey herpesvirus, live virus. This product is used as an aid in the prevention of very virulent Marek's disease in chickens. The product consists of one ampule of vaccine and a container of diluent.

Penicillin and streptomycin sulfate are added as bacteriostatic agents.

Contains amphotericin B as a fungistatic agent.

Marek's Disease Vaccine (Rispens CVI 988 Strain + HVT) Indications

This Marek's disease vaccine is recommended for use in healthy one day-old chickens. It is essential that the chickens be maintained under good environmental conditions and that exposure to disease viruses be reduced as much as possible.

Dosage and Administration

Preparation of Vaccine for Use: Read full instructions which must be followed exactly for best results. Guard against exposure to Marek's disease for at least two weeks.

Important: Sterilize vaccinating equipment by autoclaving a minimum of 15 minutes at 250°F (121°C) or boiling in water for at least 20 minutes. Never allow chemical disinfectants to come in contact with vaccinating equipment.

1. Know and follow all precautions and safety practices for handling liquid nitrogen.

2. Before withdrawing vaccine from liquid nitrogen, protect hands with gloves, wear long sleeves and protect face with a plastic face shield or wear protective goggles.

3. Remove from the liquid nitrogen only the ampules that are going to be used immediately. Match the dosage size of the vaccine ampules and diluent bottle using 200 mL of sterile diluent for each 1,000 doses of vaccine indicated on the ampule. Move quickly, but carefully.

4. Place the ampule(s) in a large, clean container of lukewarm water (75° to 85°F) to thaw ampule quickly. Gentle agitation promotes rapid thawing and evenly distributes the vaccine in the ampule. Thaw the entire contents.

5. Mix vaccine with room temperature diluent immediately after thawing. Remove closure from top of diluent bottle. Draw vaccine from the ampule into a sterile 10 mL mixing syringe fitted with an 18 to 20 gauge needle.

6. Slowly expel contents into the diluent bottle. Rinse the ampule once with the diluted vaccine.

7. Place the diluted vaccine into an ice bath. Agitate as needed to ensure a uniform suspension of the cells.

8. Use the vaccine/diluent mixture immediately as described below.

Method Of Vaccination:

1. Give subcutaneously only.

2. Use a sterile automatic syringe with a 20-22 gauge 3/8”-1/2” needle that is set to accurately deliver 0.2 mL per dose. Check the accuracy of delivery several times during the vaccination procedure.

3. Dilute the vaccine only as directed, observing all precautions and warnings for handling.

4. Keep the bottle of diluted vaccine in an ice bath and agitate continuously.

5. Inject chickens under the loose skin at the back of the neck (subcutaneously), holding the chicken by the back of the neck just below the head. The loose skin in this area is raised by gently pinching with the thumb and forefinger. Insert the needle beneath the skin in a direction away from the head. Inject 0.2 mL per chicken. Avoid hitting the muscles and bones in the neck.

6. Use the entire contents of vaccine container within one hour after mixing the vaccine with the diluent.

7. Burn all discarded containers and unused contents. Do not vaccinate within 21 days before slaughter.

Precaution(s): Storage Conditions: Ampules: Store in liquid nitrogen container.

Diluent: Store at room temperature.

Liquid Nitrogen Container: Carefully observe all liquid nitrogen precautions including wearing eye protection and gloves. Store in a cool, well-ventilated area. Check liquid nitrogen level daily. Keep container away from incubator intakes and chicken boxes.

Use entire contents when first opened.

Burn this container and all unused contents.

Caution(s): Do not vaccinate diseased birds.

Vaccinate all birds on the premises at one time.

Administer a full dose to each bird.

Avoid stress conditions during and following vaccination.

Do not place chickens in contaminated facilities.

Exposure to disease must be minimized as much as possible.

Give subcutaneously only.

Administer only as recommended.

The capability of this vaccine to produce satisfactory results depends upon many factors, including - but not limited to - conditions of storage and handling by the user, administration of the vaccine, health and responsiveness of individual chickens and degree of field exposure. Therefore, directions for use should be followed carefully. The use of this vaccine is subject to applicable local and federal laws and regulations.

Warning(s): Do not vaccinate within 21 days before slaughter.

For veterinary use only.

Liquid Nitrogen Precautions: The liquid nitrogen containers and vaccines should be handled only by properly trained personnel. These persons should be familiar with the Union Carbide publication “Precautions and Safe Practices - Liquid Atmospheric Gases,” form #9888. Liquid nitrogen is extremely cold. Accidental contact with skin or eyes can cause severe frostbite. Protect eyes with goggles or face shield. Wear gloves and long sleeves when removing and handling frozen ampules or when adding liquid nitrogen to the container. Storage and handling of liquid nitrogen containers should be in a well ventilated area. Excessive amounts of nitrogen reduce the concentration of oxygen in the air of an unventilated space and can cause asphyxiation. If drowsiness occurs, get fresh air quickly and ventilate the entire area. If a person becomes groggy or loses consciousness while working with liquid nitrogen, get the person to a well-ventilated area immediately. If breathing has stopped, begin artificial respiration. Call a physician immediately.

Trial Data: Merial Select's vaccines have met the requirements of the USDA in regard to safety, purity, potency and the capability to protect susceptible chickens. This vaccine has been tested by the Master Seed immunogenicity test for efficacy.

Presentation: 5 x 1,000 doses and 5 x 2,000 doses.

NAC No.: 11050251

MERIAL, INC. (AVIAN)
3239 SATELLITE BLVD., DULUTH, GA, 30096
Telephone:   888-637-4251
Website:   www.merial.com
Every effort has been made to ensure the accuracy of the Marek's Disease Vaccine (Rispens CVI 988 Strain + HVT) information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2014 North American Compendiums. Updated: 2014-09-05

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