Lopatol 500 (Canada)

This page contains information on Lopatol 500 for veterinary use.
The information provided typically includes the following:
  • Lopatol 500 Indications
  • Warnings and cautions for Lopatol 500
  • Direction and dosage information for Lopatol 500

Lopatol 500

This treatment applies to the following species:
Manufacturer: Novartis

(nitroscanate)

Lopatol (nitroscanate) is an oral broad-spectrum anthelmintic for dogs.

DIN 00623016 (100 mg), 00623024 (500 mg)

Description

Chemically, nitroscanate is 4-nitro-4'-isothiocyano-diphenyl ether.

Lopatol 100 contains 100 mg of nitroscanate in each tablet and Lopatol 500 contains 500 mg of nitroscanate in each tablet.

Lopatol 500 Indications

Lopatol is indicated for the treatment of infestations in dogs of:

Roundworms caused by Toxocara canis, Toxascaris leonina.

Hookworms caused by Ancylostoma caninum, Uncinaria stenocephala.

Tapeworms caused by Taenia spp., Dipylidium caninum.

Dosage

For roundworms, hookworms and tapeworms.

50 mg/kg of body weight - one 100 mg tablet per 2 kg body weight or - one 500 mg tablet per 10 kg body weight.

Example:

Weight of dog - kg

1-2

3-4

5-6

7-8

9-10

20

30

40

Number of tablets

 

Lopatol 100

1

2

3

4

 

 

 

 

Lopatol 500

 

 

 

 

1

2

3

4

Administration

Give Lopatol to the fasting dog in the morning at the same time as 1/4 of the daily food ration; give the rest of the ration in the evening. Abundant drinking water should be made available.

Routine Treatment Schedule

Pups: Can be dewormed at the age of 2, 4, 6, 8 and 12 weeks in view of the danger of re-infection by ascarids.

Adult Dogs: Deworming once or twice a year as prescribed by the veterinarian.

Breeding Bitches: Treat after mating and shortly before and 4 weeks after whelping.

Kennels: Because of the increased infestation risk, it is recommended that all dogs in breeding kennels be dewormed 4 to 6 times a year.

Toxicology

Acute LD50 values

Mouse: 3177 mg/kg, rat: 3503 mg/kg, rabbit: 10,000 mg/kg.

Signs of acute toxicity are sedation, dyspnea, exophthalmos, curved position and ruffled fur. No organ changes were seen.

Twenty cross-bred dogs, eleven males/nine females, were treated with up to 2,000 mg/kg. Some of the dogs given 500 mg/kg or more vomited after treatment, and all dogs showed some general depression and inappetence for 48 hours after the treatment. No dogs died as a result of the treatments. In clinical chemistry tests carried out, no correlation was found between deviation from control values and treatment rate.

Chronic Study

Six beagle cross-bred puppies, four males and two females, were used in this study. An initial dose of 200 mg/kg at the age of three weeks, and 26 subsequent two weekly doses at the rate of 100 mg/kg were administered. No symptoms of toxicity were observed in the treated dogs (4/6). Seven quantitative parameters were examined, and no significant changes were observed which could be related to the chemical treatment. When the dogs had reached maturity, sperm mobility tests gave no indication of abnormalities. The bitches were joined by treated dogs and have produced normal progeny.

Reproduction Studies

Lopatol did not have any toxic effect on pregnant bitches or their litters apart from a slight increase in some individual enzyme levels.

No clinical symptoms of toxicity or abortion were observed, and all bitches receiving Lopatol delivered healthy puppies at the end of their normal gestation period.

Contraindications

As with other vermicides, Lopatol should not be administered to severely debilitated animals.

Warnings

Keep out of reach of children.

Adverse Reactions

Vomiting that may occur has no negative influence on the efficacy of Lopatol Tablets.

Precautions

Lopatol should not be administered concomitantly with other anthelmintics.

Packaging

Lopatol 100 Boxes of 6 tablets which are packaged 24 in a display carton.

Lopatol 500 Boxes of 4 tablets which are packaged 24 in a display carton.

Novartis Animal Health Canada Inc., Suite 400, Plaza 3, 2000 Argentia Road, Mississauga, Ontario, L5N 1V9

® Registered Trademark of Novartis AG - Novartis Animal Health Canada Inc. licensed user

917013 21319 CAN-u

NAC No.: 12310171

NOVARTIS ANIMAL HEALTH CANADA INC.
2000 ARGENTIA RD., SUITE 400, PLAZA 3, MISSISSAUGA, ON, L5N 1V9
Telephone:   800-387-6325
Order Desk:   800-387-6325
Fax:   905-567-0221
Fax Orders:   800-827-5782
Website:   www.ah.novartis.ca
Email:   ah.questions@novartis.com
Every effort has been made to ensure the accuracy of the Lopatol 500 information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2014 North American Compendiums. Updated: 2014-04-11

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