Medication Guide App

Leptoferm-5 (Canada)

This page contains information on Leptoferm-5 for veterinary use.
The information provided typically includes the following:
  • Leptoferm-5 Indications
  • Warnings and cautions for Leptoferm-5
  • Direction and dosage information for Leptoferm-5

Leptoferm-5

This treatment applies to the following species:
Manufacturer: Zoetis

Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin

PRODUCT DESCRIPTION: Leptoferm-5 is for vaccination of healthy swine and cattle as an aid in preventing leptospirosis caused by Leptospira canicola, L. grippotyphosa, L. hardjo, L. icterohaemorrhagiae and L. pomona. Leptoferm-5 contains chemically inactivated whole cultures of 5 Leptospira serovars.

DISEASE DESCRIPTION: Leptospirosis is a worldwide disease of animals and humans and causes serious economic loss to the livestock industry.1 The disease is usually transmitted by direct or indirect contact with leptospira-infected urine.

Leptospirosis in swine is characterized by poor productivity, fever, anemia, kidney inflammation, and abortions; late-term abortions are the most important effect. In calves, clinical signs of leptospirosis may include fever, prostration, loss of appetite, shortness of breath, anemia, and blood in the urine. In adult cattle, the most common clinical sign is reproductive loss, including abortion and premature or full-term birth of weak calves. Decreased milk production may also occur.2 Leptospira spp. are known zoonotic pathogens.

All the above Leptospira serovars produce identical clinical signs, yet immunity to leptospirosis is serovar-specific.1 Vaccination against each serovar therefore is indicated for protection.

SAFETY AND EFFICACY: During developmental tests and in extensive field use of Leptoferm-5, no significant postvaccination reactions were reported.

Although L. hardjo has been isolated from field cases of leptospirosis, attempts to experimentally induce clinical disease with that serovar have yielded unreliable results. Hence, no valid challenge-of-immunity tests on L. hardjo bacterin have been possible. Recent reports, however, have identified a method to induce clinical L. hardjo infection in cattle2 and have also identified 2 distinct genotypes of L. hardjo in cattle.3,4

Accordingly, challenge-of-immunity tests were conducted to determine the efficacy of Leptoferm-5 against both L. hardjo genotypes.5 Seventeen healthy heifers were divided into 2 groups of 6 vaccinates each and a group of 5 nonvaccinated controls. Vaccinates were administered the L. hardjo component of Leptoferm-5 in 1- or 2-dose regimens. Subsequently, all cattle were challenged with disease-causing strains of both L. hardjo genotypes. After challenge, leptospires were recovered from the urine of all controls, which continued shedding leptospires in the urine until necropsy at 31-49 days after challenge. Three controls (60%) also experienced fever and developed leptospires in the blood. Conversely, leptospires were not recovered from the urine or kidneys of any vaccinates, and leptospires were recovered from the blood of only 1 vaccinate (8%) for 1 day.

Thus, efficacy of the L. hardjo component against both genotypes in cattle was confirmed. These results are similar to results of previously conducted challenge-of-immunity tests on the other 4 fractions of Leptoferm-5 in both cattle and swine. In those studies also, vaccinated animals remained healthy after challenge, while nonvaccinated animals developed clinical signs of leptospirosis.

Directions For Use

1. General Directions: Vaccination of healthy swine and cattle is recommended. Shake well. Aseptically administer 2 mL intramuscularly. In accordance with Beef Quality Assurance guidelines, this product should be administered in the muscular region of the neck.

2. Primary Vaccination: Administer a single 2-mL dose to healthy cattle. Healthy swine should receive 2 doses administered 3-6 weeks apart.

3. Revaccination: Annual revaccination with a single dose is recommended for both species.

4. Good animal husbandry and herd health management practices should be employed.

Precautions

1. Store at 2°-7°C. Prolonged exposure to higher temperatures may adversely affect potency. Do not freeze.

2. Use entire contents when first opened.

3. Sterilized syringes and needles should be used to administer this vaccine.

4. Do not vaccinate within 21 days before slaughter.

5. As with many vaccines, anaphylaxis may occur after use. Initial antidote of epinephrine is recommended and should be followed with appropriate supportive therapy.

6. This product has been shown to be efficacious in healthy animals. A protective immune response may not be elicited if animals are incubating an infectious disease, are malnourished or parasitized, are stressed due to shipment or environmental conditions, are otherwise immunocompromised, or the vaccine is not administered in accordance with label directions.

References

1. Bey RF, Johnson RC: Current status of leptospiral vaccines. Progress in Veterinary Microbiology and Immunology, Vol. 2. Pandy R, ed., Switzerland, Karger S, pp.175-197, 1986.

2. Ellis WA, O'Brien JJ, Neil SD, et al: Bovine leptospirosis: Experimental serovar hardjo infection. Vet Microbiol 11:293-299, 1986.

3. Marshall RB, Winter PJ, Thiermann AB, et al: Genotypes of Leptospira interrogans serovar hardjo in cattle in the U.K. Vet Rec 117:669-670, 1985.

4. Thiermann AB, Ellis WA: The present state of leptospirosis diagnosis and control. Proceedings, CEC Programme of Research on Animal Pathology. Ellis WA, Little TWA, eds., Netherlands, Martinus Nijhoff, 1986.

5. Ellis WA, Zygraich N: Experimental studies with a Leptospira interrogans serovar hardjo vaccine. Proceedings, Fourteenth World Congress on Diseases of Cattle. Hartigan PJ, Monaghan ML, eds., Ballsbridge, University College Dublin, 1986.

Technical inquiries should be directed to Pfizer Animal Health Technical Services, (800) 366-5288 (USA), (800) 461-0917 (Canada).

For veterinary use only

U.S. Veterinary License No. 189

Pfizer Animal Health, Exton, PA 19341, USA, Div. of Pfizer Inc., NY, NY 10017

75-4475-16

® Registered trademark of Pfizer Products Inc; Pfizer Canada Inc., licensee

Presentation: Available in 10 and 50 dose vials.

NAC No.: 11980574

ZOETIS CANADA
16,740 TRANS-CANADA HIGHWAY, KIRKLAND, QC, H9H 4M7
Order Desk:   800-663-8888
Technical Services Canada:   800-461-0917
Technical Services USA:   800-366-5288
Website:   www.zoetis.ca
Every effort has been made to ensure the accuracy of the Leptoferm-5 information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2014 North American Compendiums. Updated: 2014-09-05

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