Ketaset (Canada)This page contains information on Ketaset for veterinary use.
The information provided typically includes the following:
- Ketaset Indications
- Warnings and cautions for Ketaset
- Direction and dosage information for Ketaset
KetasetThis treatment applies to the following species:
(ketamine Hydrochloride Injection Usp)
For Veterinary Use Only
KETASET (ketamine hydrochloride) is a new rapid acting, nonbarbiturate general anesthetic for cats, chemically designated 2 - (o-chlorophenyl)-2-methylamino-cyclohexanone hydrochloride. It is supplied as a slightly acid (pH 3.5 - 5.5) solution for intramuscular injection in a concentration containing ketamine (as ketamine hydrochloride) 100 mg per mL and contains 0.10 mg/mL benzethonium chloride as a preservative.
KETASET (ketamine hydrochloride) is a rapid acting anesthetic producing an anesthetic state characterized by profound analgesia; normal pharyngeal - laryngeal reflexes and skeletal muscle tone, mild cardiac stimulation and some respiratory depression. The anesthetic state produced by ketamine has been termed “dissociative anesthesia” in that it appears to selectively interrupt association of the brain before producing somesthetic sensory blockade.
Following administration of the recommended doses of KETASET (ketamine hydrochloride), blood pressure and heart rate are usually moderately and transiently increased. Respiratory rate, on the other hand, is usually decreased in cats. The pharyngeal reflexes are maintained thus aiding in the maintenance of a patent airway. Although some salivation is occasionally noted, the persistence of the swallowing reflex effectively reduces the hazards of salivation.
Other reflexes, e.g., corneal, pedal, etc., are maintained under KETASET (ketamine hydrochloride) anesthesia, and should not be used as criteria for depth of anesthesia. Moreover, the eyes normally remain open with the pupil dilated, making it prudent to apply a bland ointment if anesthesia is to be prolonged. By single intramuscular injection in cats KETASET (ketamine hydrochloride) has a wide margin of safety.
Following administration of recommended doses of KETASET (ketamine hydrochloride) most cats become ataxic in about 5 minutes, and anesthesia will normally last 30-45 minutes. Recovery is generally smooth and uneventful, especially if animals are not stimulated by sound or handling during the recovery period. At the lower doses complete recovery usually occurs in 4-5 hours but with higher levels of KETASET (ketamine hydrochloride) recovery time is more prolonged and less predictable. With high levels complete recovery may take 24 hours or more in some selected cases, especially if the patient is in poor condition or suffering from nephritis.
KETASET (ketamine hydrochloride) is recommended as the sole anesthetic agent for diagnostic and surgical procedures. Although best suited to short procedures, it can be used, with additional doses, in procedures requiring anesthesia for periods of six (6) hours or longer.
For use in cats only.
The use of KETASET (ketamine hydrochloride) is not indicated in kittens under 12 weeks of age as it is not unusual in immature cats for anesthesia to be of shorter duration. Ketamine hydrochloride is contraindicated for procedures in cats requiring complete skeletal muscle relaxation.
Because the drug is excreted in the urine by cats, largely unchanged, caution should be exercised in dosing subjects with severe renal impairment. Caution should also be exercised in administering the drug to animals with cardiovascular abnormalities due to its hypertensive effect in cats. Premedication with atropine may, to some degree, deepen and prolong anesthesia in the cat.
At high dosage, respiratory depression may occur. If at any time cyanosis occurs, or if respiration becomes excessively depressed, resuscitative measures should be instituted promptly, e.g., artificial respiration, oxygen administration, etc.
Administration And Dosage
KETASET (ketamine hydrochloride) is well tolerated by cats when administered by intramuscular injection.
Fasting prior to induction of anesthesia by KETASET (ketamine hydrochloride) is not essential; however, when preparing for elective surgery it is prudent to withhold food for at least six (6) hours prior to induction of anesthesia.
DosageAs with other general anesthetic agents, the individual response to KETASET (ketamine hydrochloride) is somewhat varied depending upon the dose, general condition and age of the subject so that the dosage recommendations cannot be absolutely fixed.
The Following Schedule Of Dosage Is Recommended11-22 mg/kg body weight; MINOR SURGERY, SUTURING, ETC., MINOR DENTAL PROCEDURES, SIMPLE DIAGNOSTIC X-RAY, RESTRAINT FOR EXAMINATION (INCLUDING INTERIOR OF EYE), DRESSING, GROOMING, ETC.
22-33 mg/kg body weight: CASTRATION, CATHETERIZATION, DECLAWING.
33-44 mg/kg body weight: GENERAL SURGERY, ABDOMINAL SURGERY (INCLUDING OVARIOHYSTERECTOMY), ORTHOPEDIC SURGERY, MAJOR DENTISTRY.
StorageStore in a cool place, protect from light. Colour of solution may vary from colourless to very slightly yellowish and may darken upon prolonged exposure to light. Do not use if particulate material appears.
KETASET (ketamine hydrochloride) is supplied in multidose 10 mL and 50 mL vials of a solution containing 100 mg/mL.
Trademarks used under license
© Wyeth 2006. All Rights Reserved.
Wyeth Animal Health, Division of Wyeth Canada, Guelph, Ontario N1K 1E4
17,300 TRANS-CANADA HIGHWAY, KIRKLAND, QC, H9J 2M5
|Technical Services Canada:||800-461-0917|
|Technical Services USA:||800-366-5288|
|Every effort has been made to ensure the accuracy of the Ketaset information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.|
Copyright © 2013 North American Compendiums. Updated: 2013-05-17