Heartgard-30 Tablets for Dogs (136 mcg) (Canada)

Manufacturer: Merial

(ivermectin)

Veterinary Use Only

Heartgard-30 Tablets for Dogs (136 mcg) Indication

For use in dogs to prevent canine heartworm disease. HEARTGARD-30 Tablet (ivermectin) prevents heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection.

Dosage

HEARTGARD-30 Tablets are to be administered orally at the recommended minimum dose level of 6 µg of ivermectin per kilogram of body weight at monthly dosing intervals (See ADMINISTRATION). The recommended dosage schedule for prevention of canine heartworm disease is as follows:

Dog Weight	Tablets Per Month	Ivermectin Per Tablet	Product Number	Color Coding On Carton
Up to 11 kg	1	68 µg	38171A(CA)	Blue
12 to 22 kg	1	136 µg	38172A(CA)	Green
23 to 45 kg	1	272 µg	38173A(CA)	Brown

Give Dogs Over 45 Kg The Appropriate Combination Of These Tablets.

Administration

The HEARTGARD-30 Tablet should be given so that dogs swallow the whole tablet. (The tablet may be wrapped in food to encourage consumption.) The dog should be closely observed for several minutes following administration to make sure that the entire dose has been consumed. If it is suspected that any of the dose has been lost, redosing is recommended. The proper dose should be given at monthly intervals during the period of the year when mosquitoes (vectors) potentially carrying infective heartworm larvae are active. The initial dose must be given within a month after the first exposure to mosquitoes. The final dose must be given within amonth after the last exposure to mosquitoes.

When replacing another heartworm preventive in a heartworm prevention program, the first dose of HEARTGARD-30 Tablet must be given within a month after the last dose of the former medication.

If the interval between doses exceeds 30 days, the efficacy of HEARTGARD-30 Tablet will be reduced. Therefore, for optimal performance, HEARTGARD-30 Tablets must be given once a month on or about the same date. If treatment is delayed, whether by a few days or many, immediate treatment with HEARTGARD-30 Tablet and reinitiation of the recommended dosing regimen will minimize the opportunity for the development of adult heartworms.

Efficacy

HEARTGARD-30 Tablet, given orally using the recommended dose and regimen, is effective against the tissue larval stage acquired during the previous month (30 days) and, as a result, prevents the development of adult Dirofilaria immitis.

Safety

Clinical studies have shown a wide safety margin at the recommended dose level in dogs including pregnant or breeding bitches, and stud dogs.

Heartgard-30 Tablets for Dogs (136 mcg) Caution

To avoid future diagnostic confusion, all dogs should be tested for existing heartworm infection prior to starting treatment with HEARTGARD-30 Tablet. (HEARTGARD-30 Tablet should be administered only to dogs found negative.) A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea, may occur after the treatment of dogs that have circulating microfilariae.

WARNING: Keep this and all drugs out of the reach of children. In case of human consumption, clients should be advised to contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of human consumption.

Availability

HEARTGARD-30 Tablet is available in three dosage strengths (See DOSAGE section) for dogs of different weights. Each strength comes in a convenient 6-tablet carton, packed 10 cartons per tray.

DIN 00651966 (68 µg), 00651982 (136 µg), 00651990 (272 µg)

^®Registered trademark of Merial, ™Trademark of Merial.

Copyright © 2001 Merial

All Rights Reserved.

Merial Canada Inc., 500 boul. Morgan, bureau 1, Baie d’Urfé Qc H9X 3V1

May 2001

Merial Limited: Registered in England and Wales [Reg. No. 3332751] with registered offices at 27 Knightsbridge, London, SW1X7QT, England and domesticated in Delaware, USA as Merial LLC.

8792402

Nac No.

11820322