Medication Guide App

Footvax 10 Strain

This page contains information on Footvax 10 Strain for veterinary use.
The information provided typically includes the following:
  • Footvax 10 Strain Indications
  • Warnings and cautions for Footvax 10 Strain
  • Direction and dosage information for Footvax 10 Strain

Footvax 10 Strain

This treatment applies to the following species:
Manufacturer: Intervet/Merck Animal Health

Bacteroides nodosus Bacterin

U.S. Vet. Lic. No.: 311

Contents: The FOOTVAX® product contains 10 strains of killed Bacteroides nodosus organisms suspended in a water-in-oil emulsion.

Footvax 10 Strain Indications

A multi-strain ovine footrot bacterin for the prevention and treatment of footrot in sheep.

Dosage and Administration

Aseptically administer 1 mL under the skin in the anterior half of the neck.

Primary Vaccination: The primary course of treatment should be initiated prior to the anticipated outbreak period as dictated by local conditions. Following the first (sensitizing) dose, a second vaccination should be administered not sooner than six (6) weeks and not later than six (6) months following the initial dose.

Booster Vaccination: Following the original two dose course of treatment, booster vaccinations should be given bi-annually or just prior to an anticipated outbreak. Protection after vaccination is usually longer than four (4) months but local conditions are known to be very important in affecting this period. Booster inoculations at 4 to 6 month intervals may be beneficial in cases of severe challenge.

Administration: The FOOTVAX® product is very viscous because it contains an oil adjuvant. A considerable excess is included in each Flexipack since some of the product adheres to the sides of the container and cannot be withdrawn. Before use it should be thoroughly shaken. In very cold weather the Flexipack should be immersed in lukewarm water to make the product flow more readily. The use of an 18 gauge x 1 inch needle is recommended, except in cold weather when a 16 gauge x 1 inch needle is recommended. The product can be given through standard automatic syringes that can be accurately set to 1 mL. Sterilize all injection equipment by boiling in water for at least 10 minutes prior to use. Maintain maximum cleanliness at all times. Use aseptic technique and change needles frequently.

Precaution(s): Store away from light at not over 45°F or 7°C. Do not freeze. Use entire contents when first opened.

Caution(s): Avoid injection of dirty or wet sheep. To reduce injection site contamination use only sharp sterile disposable needles. Inject only under the skin, and not into the muscle.

The FOOTVAX® product contains an oil adjuvant which is likely to cause a localized reaction at the site of injection. The reaction can take the form of either a lump, a plaquelike swelling or occasionally a sterile abscess may occur. These reactions will normally disappear over a period of 10 weeks. However, some reactions may remain. Some evidence of localized reactions may be present for longer periods of time. Anaphylactoid reactions may occur following use.

Antidote(s): Epinephrine.

Warning(s): Do not vaccinate within 60 days before slaughter.

Accidental Human Exposure: This product does not represent an etiological hazard to humans. Accidental self-injection of the product can cause serious local reactions due to the oil emulsion. If accidental injection occurs seek medical attention at once. Inform the physician that the product contains an oil emulsion.

To the doctor: Accidental self-injection with this oil-based product can cause intense vascular spasm which may, for example, result in the loss of a digit. Expert prompt surgical attention is required and may necessitate early incision and irrigation of the injected area, especially where there is involvement of muscle, tendon sheaths or joint capsules.

For veterinary use only.

Discussion: FOOTVAX® is designed to stimulate a strong immunological response for the protection from new infection, and treatment of infection already present. It forms an essential part of the recommended footrot control program. Owing to the large differences in flock susceptibility, prevalence of the disease, and seasonal climatic factors in different parts of the United States, a specific control program incorporating FOOTVAX® should be designed in consultation with your local veterinarian.

Footrot in sheep is common in many areas of the United States and is principally caused by the bacterium Bacteroides nodosus, also known as Dichelobacter nodosus. The development of footrot is aided by wet conditions when mud and feces may accumulate on the feet, resulting in inflammation between the claws (scald). This inflammatory response facilitates invasion of the hoof by B. nodosus organisms. The disease is characterized by a progressive separation of the horny tissues from the soft tissues of the foot due to necrosis of the sensitive laminae. This usually starts to the rear of the inside of the claw proceeding to the sole and eventually progresses to the outside wall of the claw. In severe cases, there can be almost complete separation of the wall from the underlying structures. Where underrunning is severe the foot may be carried and if both front feet are severely affected the sheep may move about on its knees. There is a characteristic foul odor present.

Bacteroides nodosus, the organism responsible for footrot in sheep, is separated into groups by the differences in the hairlike structures (or pili) on the surfaces of the bacteria.

The differences between strains can only be identified by laboratory tests. Not all strains are equally pathogenic and the least destructive of them often cause only minor clinical signs. “Scald” for instance is now thought to be caused by relatively non-proteolytic (non-tissue-destructive) strains of B. nodosus. Lameness in a small portion of the flock is usually the first indication of the presence of footrot. The interdigital skin is moist with some erosion and some minor underrunning may occur. Death of the underlying tissues does not occur although the usual footrot odor is present. In most cases of “scald” there is natural regression and healing. “Scald” of this nature should be referred to as benign footrot. In fact, any infection of the interdigital skin by bacteria such as with Fusobacterium necrophorum will present symptoms of “scald” and it is suggested that this term be used only to describe the early non-specific signs of foot disease of indeterminate origin.

Manufactured by: Schering-Plough Animal Health Limited.

Presentation: 50 dose (50 mL) vials.

NAC No.: 10470732

INTERVET INC., MERCK ANIMAL HEALTH
556 MORRIS AVE., SUMMIT, NJ, 07901
Customer Service:   800-521-5767
Order Desk:   800-648-2118
Technical Service (Companion Animal):   800-224-5318
Technical Service (Livestock):   800-211-3573
Fax:   908-473-5560
Website:   www.merck-animal-health-usa.com
Every effort has been made to ensure the accuracy of the Footvax 10 Strain information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2014 North American Compendiums. Updated: 2014-05-28

(web3)