Distox-Plus

Manufacturer: Schering-Plough

Mink Distemper-Enteritis Vaccine, Modified Live and Killed Virus-Clostridium botulinum Type C-Pseudomonas aeruginosa Bacterin-Toxoid

U.s. Vet. Lic. No.

165A

Contents

This vaccine is made up of two components: a lyophilized (dried) vaccine containing a modified live distemper virus grown in chicken embryo tissue culture and combined with stabilizing agents; and a liquid fraction containing an inactivated mink enteritis virus grown in feline cell line combined with Clostridium botulinum Type C-Pseudomonas aeruginosa Bacterin-Toxoid with an aluminum adjuvant. The liquid bacterin-toxoid component serves as diluent for rehydrating the dried distemper vaccine and has been processed and tested especially to allow mixing of this triple combination vaccine in the field. Contains gentamicin and amphotericin B as preservatives.

Distox-Plus Indications

This vaccine is for use in mink 8 weeks of age or older, as an aid in preventing distemper, virus enteritis and type C botulism and hemorrhagic pneumonia through vaccination by subcutaneous injection.

Distox-Plus Dosage And Administration

Eight weeks of age or older. Revaccinate all breeders annually for type C botulism and distemper about one month before mating season.

Preparation of the Vaccine: Do not open and mix the vaccine until ready for use.

Mix only one vial at a time and use entire contents within two hours.

Disinfect exposed rubber stoppers with alcohol or other disinfectants.

Shake the liquid bacterin-toxoid component well before use.

Using a sterile transfer needle, or a sterile needle and syringe, transfer the entire contents of the liquid bacterin-toxoid bottle into the bottle of dried distemper vaccine. (Insert transfer needle into bacterin-toxoid diluent first, turn bacterin-toxoid diluent bottle upside down, then insert other end of transfer needle into dried distemper vaccine bottle. Bacterin-toxoid diluent will be drawn into distemper vaccine bottle by vacuum.)

As soon as all bacterin-toxoid diluent has been transferred, shake the completed vaccine well to suspend evenly.

The vaccine is now ready for use.

How to Vaccinate: For all mink, inject 1.0 mL (cc) subcutaneously under the skin, preferably in the region of the armpit (axillary space).

Records: Keep a record of vaccine type, quantity, serial number, expiration date, and place of purchase; the date and time of vaccination; the number, age, and location of the mink; names of operators performing the vaccination and any observed reactions.

Contraindication(s)

Mink kits younger than 8 weeks of age and born from distemper-vaccinated female breeders may possess strong maternal immunity which can interfere with the distemper fraction of this vaccine. Thus, vaccination of such mink is not recommended before 8 weeks of age.

Precaution(s)

Store at 2° to 7°C (35° to 45°F).

Use only sterile needles and syringes to inject the vaccine. Syringes and needles may be sterilized by boiling for 15 to 20 minutes. Do not disinfect with chemicals since they may destroy the distemper vaccine virus.

Do not transfer vaccine to other containers.

Protect the vaccine from excessive light and heat.

Use entire contents of vial when first opened. Do not save any unused portion of the vaccine mixture for later use.

Do not spill or spatter the vaccine. Burn empty bottles, caps and all unused vaccine and accessories.

Do not dilute the vaccine or otherwise stretch the dosage.

Distox-Plus Caution(s)

Vaccinate only healthy animals. Although disease may not be evident, Aleutian disease, urinary tract infections, boils or other disease conditions may cause complications or reduce protection.

Warning(s)

For veterinary use only.

Presentation

100 dose and 250 dose vials.

Nac No.

10470441