Cestex

This page contains information on Cestex for veterinary use.
The information provided typically includes the following:
  • Cestex Indications
  • Warnings and cautions for Cestex
  • Direction and dosage information for Cestex

Cestex

This treatment applies to the following species:
Manufacturer: Zoetis

(epsiprantel)

Veterinary Tablets

Cestex (epsiprantel) tablets are indicated for the removal of tapeworms in the cat (Dipylidium caninum and Taenia taeniaeformis) and dog (Dipylidium caninum and Taenia pisiformis).

Cestex Caution

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Description

Cestex tablets are film-coated and contain 12.5 mg, 25 mg, 50 mg or 100 mg of epsiprantel per tablet.

Epsiprantel is an anthelmintic that is active as a single dose against the common tapeworms of cats and dogs. Epsiprantel has a molecular weight of 326 and is chemically 2-(cyclohexylcarbonyl)-4-oxo 1,2,3,4,6,7,8,12b-octahydropyrazino[2,1-a][2]benza-zepine. It is a stable white solid which is sparingly soluble in water. Its chemical structure is presented below.

Action: Epsiprantel acts directly on the tapeworm. Since it is minimally absorbed following oral administration, epsiprantel remains at the site of action within the gastrointestinal tract. Due to digestive process, tapeworm fragments or proglottids may not be readily visible in the stool.

Cestex Indications and Usage

Cestex tablets are indicated for the removal of the following:

Feline cestodes: Dipylidium caninum and Taenia taeniaeformis

Canine cestodes: Dipylidium caninum and Taenia pisiformis

Contraindications

There are no known contraindications to the use of this drug.

Warnings

For use in cats and dogs only. Safety of use in pregnant or breeding animals has not been determined. Keep out of reach of children. Not for use in humans.

PRECAUTION: Do not use in kittens or puppies less than 7 weeks of age.

Dosage and Administration

Cestex tablets should be administered orally.

The recommended dosage of epsiprantel is: cats, 1.25 mg/lb of body weight; dogs, 2.5 mg/lb of body weight. The following table may be used as a guide:

Dosage Schedule

Feline

Body Weight

Dose

Seven weeks old

up to 10 lb

12.5 mg

11-20 lb

25.0 mg

Canine

Body Weight

Dose

Seven weeks old

up to 5 lb

12.5 mg

6-10 lb

25.0 mg

11-20 lb

50.0 mg

21-40 lb

100.0 mg

41-50 lb

125.0 mg

51-60 lb

150.0 mg

61-80 lb

200.0 mg

81-90 lb

225.0 mg

91-100 lb

250.0 mg

101+ lb

2.5 mg/lb, rounding up to next whole tablet combination

Fasting is not necessary or recommended.

Unless exposure to the infected intermediate hosts is controlled, reinfection is likely and retreatment may be required. In the case of D. caninum, an effective flea control program should be instituted.

SAFETY: Epsiprantel has been evaluated in cats at 5 times the recommended dose given once daily for 3 days with no adverse effects noted. In tolerance studies, epsiprantel produced minimal clinical signs in cats given 40 times the recommended dose once daily for 4 days.

Epsiprantel has been evaluated in 14-day repeat dose studies in dogs at 500 mg/kg (90 times recommended dosage) with no significant adverse results. No side effects were observed during the clinical field studies.

Epsiprantel is not a cholinesterase inhibitor. During the course of clinical field studies, Cestex was administered concurrently with diethylcarbamazine citrate (dogs only), anti-inflammatory agents, insecticides, and nematocides with no drug incompatibilities noted.

Storage

Store at controlled room temperature 20°-25°C (68°-77°F) with excursions between 15°-30°C (59°-86°F).

How Supplied

Cestex tablets are film-coated and contain 12.5 mg, 25 mg, 50 mg or 100 mg of epsiprantel per tablet. Cestex is supplied as described below:

Concentration

Weight (lbs)

Number Tablets/Bottle

Cat

Dog

12.5 mg

10

5

50, 100

25.0 mg

20

10

50, 100

50.0 mg

- -

20

25, 50

100.0 mg

- -

40

25, 50

NADA #140-893, Approved by FDA

Distributed by: Zoetis Inc., Kalamazoo, MI 49007

13915900

Revised: January 2013

NAC No.: 36900884

ZOETIS INC.
333 PORTAGE STREET, KALAMAZOO, MI, 49007
Telephone:   269-833-4000
Customer Service:   888-963-8471
Website:   www.zoetis.com
Every effort has been made to ensure the accuracy of the Cestex information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2014 North American Compendiums. Updated: 2014-09-05

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