Cestex

Action

Epsiprantel acts directly on the tapeworm. Since it is minimally absorbed following oral administration, epsiprantel remains at the site of action within the gastrointestinal tract. Due to digestive process, tapeworm fragments or proglottids may not be readily visible in the stool.

Cestex Indications And Usage

Cestex tablets are indicated for the removal of the following:

Feline cestodes: Dipylidium caninum and Taenia taeniaeformis

Canine cestodes: Dipylidium caninum and Taenia pisiformis

Contraindications

There are no known contraindications to the use of this drug.

Warnings

For use in cats and dogs only. Safety of use in pregnant or breeding animals has not been determined. Keep out of reach of children. Not for use in humans.

Precaution

Do not use in kittens or puppies less than 7 weeks of age.

Cestex Dosage And Administration

Cestex tablets should be administered orally.

The recommended dosage of epsiprantel is: cats, 1.25 mg/lb of body weight; dogs, 2.5 mg/lb of body weight. The following table may be used as a guide:

Dosage Schedule

Feline

Body Weight	Dose
Seven weeks old
up to 10 lb	12.5 mg
11-20 lb	25.0 mg

Canine

Body Weight	Dose
Seven weeks old
up to 5 lb	12.5 mg
6-10 lb	25.0 mg
11-20 lb	50.0 mg
21-40 lb	100.0 mg
41-50 lb	125.0 mg
51-60 lb	150.0 mg
61-80 lb	200.0 mg
81-90 lb	225.0 mg
91-100 lb	250.0 mg
101+ lb	2.5 mg/lb, rounding up to next whole tablet combination

Fasting is not necessary or recommended.

Unless exposure to the infected intermediate hosts is controlled, reinfection is likely and retreatment may be required. In the case of D. caninum, an effective flea control program should be instituted.

Safety

Epsiprantel has been evaluated in cats at 5 times the recommended dose given once daily for 3 days with no adverse effects noted. In tolerance studies, epsiprantel produced minimal clinical signs in cats given 40 times the recommended dose once daily for 4 days.

Epsiprantel has been evaluated in 14-day repeat dose studies in dogs at 500 mg/kg (90 times recommended dosage) with no significant adverse results. No side effects were observed during the clinical field studies.

Epsiprantel is not a cholinesterase inhibitor. During the course of clinical field studies, Cestex was administered concurrently with diethylcarbamazine citrate (dogs only), anti-inflammatory agents, insecticides, and nematocides with no drug incompatibilities noted.

Storage

Store at controlled room temperature 15°-30°C (59°-86°F).

How Supplied

Cestex tablets are film-coated and contain 12.5 mg, 25 mg, 50 mg or 100 mg of epsiprantel per tablet. Cestex is supplied as described below:

Concentration	Weight (lbs)		Number Tablets/bottle
	Cat	Dog
12.5 mg	10	5	50, 100
25.0 mg	20	10	50, 100
50.0 mg	- -	20	25, 50
100.0 mg	- -	40	25, 50

NADA #140-893, Approved by FDA

Distributed by: Pfizer Animal Health, Div. of Pfizer Inc, NY, NY 10017

MADE IN INDIA

75-8032-10IN01

December 2007

Nac No.

36900883