Broilerbron-H N-79

Manufacturer: Intervet/Schering-Plough Animal Health

Newcastle-Bronchitis Vaccine, B₁ Type, LaSota Strain, Mass. Type, Live Virus

U.s. Vet. Lic. No.

226

Contents

Newcastle-bronchitis vaccine (B₁ type, LaSota strain, Mass. type), live virus. Gentamicin is added as a bacteriostatic agent.

Broilerbron-H N-79 Indications

This vaccine is recommended for initial vaccination of healthy chickens 2 weeks of age or older by intraocular or drinking water methods of application against Newcastle disease and infectious bronchitis (Mass. type). For use in broilers or initial vaccination of replacement chickens.

Broilerbron-H N-79 Dosage And Administration

Rehydration of the Vaccine: For Intraocular use

Do not open and mix the vaccine until ready to begin vaccination. Use vaccine immediately after mixing.

1. Tear off the aluminum seal from the vial containing the dried vaccine.

2. Lift off the rubber stopper.

3. Remove the plastic screw-cap and applicator insert from the polyethylene bottle of diluent.

4. Pour a small amount of diluent into the vial of dried vaccine.

5. Replace the rubber stopper and shake.

6. Pour the partly dissolved vaccine into the bottle containing the rest of the diluent.

7. Replace the plastic applicator insert and screw-cap and shake vigorously until all of the material is dissolved.

The vaccine is now ready for use by the following method.

Intraocular Administration: For chickens 2 weeks of age or older.

Place one full drop of vaccine into the open eye. Do not release the chicken until after it has swallowed.

Rehydration of the Vaccine: For Drinking Water Use.

Do not open and mix the vaccine until ready to begin vaccination. Use vaccine immediately after mixing.

1. Tear off the aluminum seal from the vial containing the dried vaccine.

2. Lift off the rubber stopper.

3. Carefully pour clean, cool tap water into the vaccine vial until the vial is approximately two-thirds full.

4. Replace the rubber stopper and shake vigorously until all material is dissolved.

5. The vaccine is now ready for drinking water use in accordance with directions below. For best results be sure to follow directions carefully.

Drinking Water Administration: For chickens 2 weeks of age or older.

1. Remove all medication, sanitizers, and disinfectants from the drinking water, preferably 72 hours before vaccinating, and for 24 hours after vaccination.

2. Provide enough watering space so that at least two-thirds of the chickens can drink at one time.

3. Scrub waterers thoroughly and rinse with fresh, clean water.

4. Withhold water for 2 hours before vaccinating to stimulate thirst.

5. Rehydrate the vaccine as directed above.

6. Add rehydrated vaccine to clean, cool tap water and mix in accordance with the following chart:

Age of chickens	1,000 doses added to this amount of water
2 weeks to 4 weeks	2 1/2 Gallons (9.5 liters)
4 weeks to 8 weeks	5 Gallons (18.9 liters)
8 weeks or older	10 gallons (37.9 liters)

7. Distribute the vaccine solution, as prepared above, among the waterers provided for the chickens. Avoid placing the waterers in direct sunlight.

8. Provide no other drinking water until all the vaccine treated water has been consumed.

Contraindication(s)

Chickens to be vaccinated should be free of all diseases including latent form of chronic respiratory disease (CRD), clinical coccidiosis, blackhead, parasite infestations, etc. and maintained under good environmental conditions.

Precaution(s)

Store vaccine in refrigerator under 45°F (7°C).

Use entire contents when first opened. Burn containers and all unused contents.

Broilerbron-H N-79 Caution(s)

Consult your poultry pathologist for further recommendations based on conditions existing in a designated area at any given time.

The vaccination program for replacement pullets should not be started after chickens are 16 weeks of age.

Different vaccines should not be mixed for single application.

Chickens should not be placed on contaminated premises. Exposure should be avoided immediately after vaccination, because it takes up to 10 days to develop resistance.

All susceptible chickens on the same premises should be vaccinated at the same time. If this is not possible, then strict isolation and separate caretakers should be employed for non-vaccinated units. Efforts should be taken to reduce stressful conditions at the time the vaccine is administered.

The capacity of the vaccine to produce satisfactory results depends upon many factors including, but not limited to, conditions of storage and handling by the user, administration of the vaccine, health and responsiveness of individual animals and the degree of field exposure. Therefore, directions for use should be followed carefully.

The use of the vaccine is subject to applicable state and federal laws and regulations.

Warning(s)

Do not vaccinate within 21 days before slaughter.

Newcastle disease virus can cause inflammation of the eyelids of humans, lasting two or three days. The user should avoid contaminating his hands, eyes and clothing with this vaccine.

Discussion

The vaccine is formulated from a clone-selected LaSota strain of Newcastle disease virus (N-79) and a special modified Holland strain of infectious bronchitis virus of Mass. type (BROILERBRON^®-H). It has been demonstrated that clone-selected LaSota strain (N-79) offers the same protection as the regular LaSota strain and yet at the same time gives a mild reaction comparable to the B₁ strain. The strain of bronchitis virus was received from APHIS and further modified to reduce its potential for producing respiratory side effects and yet retain high immunizing capability. The viruses are grown under exacting standards of quality control in eggs produced by healthy chickens in closely supervised flocks.

Vaccination Programs: Many factors must be considered in determining the proper vaccination program for a particular farm or poultry operation. To be fully effective, the vaccine must be administered to healthy receptive chickens held in a proper environment under good management. In addition, the response may be modified by the age of the chickens and their immune status. Seldom does one vaccination under field conditions produce complete protection for all individuals in a given flock. The amount of protection required will vary with the type of operation and the degree of exposure that a flock is likely to encounter. For these reasons, a program of periodic revaccination may be required.

Notice: All vaccines released for sale meet the requirements of the licensing authority (U.S. Department of Agriculture) in regard to safety, purity, potency and the capacity to immunize normal, susceptible chickens.

Presentation

10 x 1,000 dose-vials.

Nac No.

10472660