Borgal (Canada)

Injection

DIN 00555657

Antibacterial Agent

VETERINARY USE ONLY

Chemistry

The active ingredients of BORGAL are a combination of trimethoprim and sulfadoxine which has been established in a ratio of 1:5.

Action

BORGAL Injection contains trimethoprim (a synthetic antibacterial), and sulfadoxine (a sulfonamide). The two components of BORGAL produce a sequential double blockade of bacterial metabolism, giving a level of activity many times greater than that obtained from either drug alone.

BORGAL provides effective antibacterial activity against a wide range of infections caused by Gram-positive and Gram-negative bacteria.

BORGAL has shown activity in vitro against the following organisms:

Very Sensitive Organisms: Escherichia coli, Bacillus anthracis, Clostridium spp, Pasteurella spp., Shigella spp., Haemophilus influenzae, Salmonella spp., Streptococcus zooepidemicus, Proteus mirabilis, Vibrio spp.

Sensitive Organisms: Streptococcus viridans, Proteus spp., Brucella spp., Actinomyces, Enterococci spp., Corynebacterium spp., Staphylococcus aureus, including penicillinase-producing organisms, Bordetella spp., Neisseria spp., Klebsiella spp.

Moderately Sensitive Organisms: Enterobacter aerogenes, Nocardia spp.

Non-sensitive Organisms: Pseudomonas aeruginosa*, Leptospira spp., Mycobacterium tuberculosis, Erysipelothrix rhusiopathiae.

*usually non-sensitive

Borgal Indications And Clinical Uses

BORGAL Injection may be used in cattle and swine where potent systematic antibacterial action against a wide range of infections caused by sensitive organisms is required.

BORGAL Injection is indicated in cattle for the treatment of:

RESPIRATORY TRACT INFECTIONS - bacterial pneumonias including bovine pneumonic pasteurellosis (shipping fever).

ALIMENTARY TRACT INFECTIONS - primary enteric and septicaemic colibacillosis and salmonellosis.

OTHER INFECTIONS - infectious pododermatitis (foot rot, foul in the foot) and septicaemias.

BORGAL Injection is indicated in swine for the treatment of:

RESPIRATORY TRACT INFECTIONS - bacterial pneumonias.

ALIMENTARY TRACT INFECTIONS - colibacillosis and post-weaning scours.

OTHER INFECTIONS - mastitis-metritis-agalactia syndrome of sows (MMA) and bacterial arthritis.

Contraindications

BORGAL Injection should not be used in cattle or swine showing marked liver parenchymal damage or blood dyscrasias, nor in those with a history of sulfonamide sensitivity.

Adverse Reactions

No significant adverse reactions have been reported.

Borgal Cautions

With intravenous therapy generally, and sulfonamides in particular, hypersensitivity reactions can occur and should be appropriately treated with corticosteroids or epinephrine.

Temporary, local, irritating swellings are encountered occasionally after intramuscular injection of BORGAL.

Warning

MILK TAKEN FROM TREATED ANIMALS WITHIN 96 HOURS AFTER THE LATEST TREATMENT MUST NOT BE USED IN FOOD. TREATED ANIMALS MUST NOT BE SLAUGHTERED FOR USE IN FOOD FOR AT LEAST 10 DAYS AFTER THE LATEST TREATMENT WITH THIS DRUG.

Borgal Dosage And Administration

BORGAL Injection should be administered at a dose rate of 16 mg/kg body weight (3 mL per 45 kg [100 lb]) daily. In piglets weighing less than 4.5 kg (10 lb) do not exceed a dose of 0.5 mL.

Intramuscular injection is recommended for cattle and swine, but if a particularly rapid response is required in acute infections, BORGAL can be administered by slow intravenous injection.

Treatment should continue for 2-3 days after symptoms have subsided. The usual course of treatment is for not longer than 5 consecutive days.

Dosage Form

BORGAL Injection is a solution containing 4% w/v trimethoprim and 20% w/v sulfadoxine in an organic solvent. Each mL contains 40 mg trimethoprim and 200 mg sulfadoxine.

Storage

Store at room temperature, below 25°C.

Supply

Bottles of 100 mL, 250 mL and 500 mL.

BORGAL, Reg. Trademark of Intervet Canada Corp.

For technical enquiries, call toll free 1 888 306-0069.

503361 QUS70012

Nac No.