AmTech Tiamulin Soluble Antibiotic

ANADA 200-344, Approved by FDA

Description

TIAMULIN Soluble Antibiotic is a fine, white powder which contains 45% w/w tiamulin. The active ingredient tiamulin chemically is 14-desoxy-14-[(2-diethylaminoethyl) mercaptoacetoxy] mutilin hydrogen fumarate, a semi-synthetic diterpene antibiotic. TIAMULIN Soluble Antibiotic is designed to be administered in the drinking water of swine.

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Tiamulin is active against Brachyspira hyodysenteriae and Actinobacillus pleuropneumoniae. It is readily absorbed from the gut and can be found in the blood within 30 minutes after dosing.

AmTech Tiamulin Soluble Antibiotic Indications

TIAMULIN, when administered in the drinking water for five consecutive days, is an effective antibiotic for the treatment of swine dysentery associated with Brachyspira hyodysenteriae susceptible to tiamulin at a dosage level of 3.5 mg tiamulin per pound of body weight daily and for treatment of swine pneumonia due to Actinobacillus pleuropneumoniae susceptible to tiamulin when given at 10.5 mg tiamulin per pound of body weight daily.

Contraindications

Swine being treated with TIAMULIN should not have access to feeds containing polyether ionophores (e.g., monensin, lasalocid, narasin, salinomycin and semduramicin) as adverse reactions may occur.

Warning

Keep out of reach of children. Avoid contact with skin. Direct contact with skin or mucous membranes may cause irritation.

Withdraw medicated water 3 days before slaughter after treatment at 3.5 mg per pound and 7 days before slaughter following treatment at 10.5 mg per pound body weight.

AmTech Tiamulin Soluble Antibiotic Caution

For use in drinking water of swine only. Prepare fresh medicated water daily. Not for use in swine over 250 pounds body weight. For animal use only - not for use in humans.

Adverse Reactions

Overdoses of tiamulin have sometimes produced transitory salivation, vomiting and an apparent calming effect on the pig.

If signs of toxicity occur, discontinue use of medicated water and replace with clean, fresh water.

In rare cases, redness of skin primarily over the ham and underline has been observed during medication. If this occurs, discontinue medication immediately.

Studies to evaluate the safety of the water soluble form of tiamulin in breeding swine have not been done.

Use Directions

The concentration of tiamulin in the drinking water must be adjusted to compensate for variation in water consumption due to weight or size of the pig, environmental temperature and other factors. It is important that pigs receive the proper drug dose, 3.5 mg tiamulin per pound for swine dysentery or 10.5 mg tiamulin per pound for Actinobacillus pneumonia each for 5 consecutive days.

Table 1

Note

1. Prepare fresh medicated drinking water every day for the 5 day treatment period.

2. Water medicated with Tiamulin Soluble Antibiotic should be the only source of drinking water during the treatment period.

Directions For Preparing Tiamulin Soluble Antibiotic Medicated Solutions

1. Pour contents of the Tiamulin Soluble Antibiotic packets into a suitable clean container.

2. Add approximately 4 quarts of water.

3. Stir thoroughly until the powder is completely dissolved.

4. Add this solution to the quantity of drinking water needed and mix well.

Table 2

*note

Directions For Using Tiamulin Soluble Antibiotic In Medicated Proportioners

2.28 oz packet

The contents of each packet dissolved in one gallon of water and this stock solution metered in a medication proportioner at one fluid ounce per gallon will deliver 227 mg of tiamulin per gallon to a total of 128 gallons of drinking water for treatment of swine dysentery. Use three 2.28 oz packets dissolved in one gallon of water and this stock solution metered in a medication proportioner at one fluid ounce per gallon to deliver 682 mg of tiamulin per gallon to a total of 128 gallons of drinking water for treatment of Actinobacillus pneumonia.

The concentration of tiamulin in the stock solution and in the drinking water delivered must be adjusted to compensate for variation in water consumption by pigs due to body weight, environmental and other factors. It is important that the pigs receive the proper drug dose of 3.5 mg per pound of body weight daily for five days for treatment of swine dysentery and 10.5 mg per pound of body weight daily for 5 days for treatment of Actinobacillus pneumonia.

Attention

If no response to treatment is obtained within 5 days, re-establish the diagnosis. Failure of response may be related to the presence of non-susceptible organisms or other complicating disease conditions. Because of the tendency for the disease to recur on premises with a history of swine dysentery or Actinobacillus pneumonia, a control program should be implemented after treatment. Drugs are not substitutes for proper sanitary measures or good management, but should be used in conjunction with such practices.

How Supplied

Store In A Dry Place Not Above 37°c (100°f).

Observe Expiration Dates.

Manufactured by IVX Animal Health, Inc., St. Joseph, MO 64503

AmTech^® is a registered trademark of IVX Animal Health, Inc.

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