Amoxicillin 100 (Canada)This page contains information on Amoxicillin 100 for veterinary use.
The information provided typically includes the following:
- Amoxicillin 100 Indications
- Warnings and cautions for Amoxicillin 100
- Direction and dosage information for Amoxicillin 100
Amoxicillin 100This treatment applies to the following species:
Veterinary Use Only
Amoxicillin (trihydrate) USP 100 mg/tablet
Therapeutic classification - Antibiotic
Active Ingredient Per Tablet
100 mg of Amoxicillin (as amoxicillin trihydrate)
ACTION: Amoxicillin 100 exhibits a bactericidal action against sensitive organisms during the active multiplication stage. It works by the inhibition of the biosynthesis of cell wall mucopeptides.
INDICATIONS and CLINICAL USE: Amoxicillin 100 is indicated in the treatment of infections due to susceptible strains of microorganisms causing the following infections in dogs and cats: Gram-negative: E. coli, P. mirabilis, Pasteurella spp., Salmonella spp. Gram-positive: Streptococci (including S. pneumoniae), Penicillin-sensitive staphylococci, Corynebacterium spp., Clostridium welchii.
UPPER RESPIRATORY INFECTIONS: Pharyngitis, Sinusitis, Tonsillitis and Tracheobronchitis.
LOWER RESPIRATORY INFECTIONS: Bronchitis, Bronchopneumonia and Lobar pneumonia.
GENITO-URINARY TRACT INFECTIONS: Cystitis, Urethritis.
Since it does not resist destruction by beta lactamase (penicillinase), it is not effective against beta lactamase producing organisms particularly staphylococci. All strains of Pseudomonas, and most strains of Klebsiella, Serratia and Enterobacter are resistant.
The possibility of superinfections with mycotic organisms or bacterial pathogens should be kept in mind during therapy. If superinfections occur (usually involving Aerobacter, Candida or Pseudomonas), Amoxicillin 100 therapy should be discontinued and appropriate measures instituted.
Periodic assessment of renal, hepatic and hematopoietic functions should be made during prolonged Amoxicillin 100 therapy.
Since Amoxicillin 100 is excreted mostly by the kidneys, reduce the dosage for patients with renal impairment in proportion to the degree of loss of renal function.
The safety of Amoxicillin 100 in the treatment of infections during pregnancy has not been established. Weigh the benefits of the drug against its possible hazards to the dam and foetus.
SKIN AND SOFT TISSUE INFECTIONS: Bacterial dermatitis, abscesses, lacerations and wounds. In emergency cases, where the causative organism is not yet identified, therapy may be initiated with Amoxicillin 100 on the basis of clinical judgement while awaiting the results of bacteriological studies to determine its antimicrobial sensitivity.
GASTROINTESTINAL TRACT INFECTIONS: Bacterial gastroenteritis.
Adverse ReactionsGastrointestinal: Nausea, vomiting and diarrhea. Hypersensitivity: Erythematous maculopapular rashes, urticants and anaphylaxis.
PRECAUTION: Serious and occasionally fatal hypersensitivity (anaphylactoid) reactions have been reported in patients on penicillin therapy.
Although anaphylaxis is more frequent following parenteral therapy, it has occured in patients on oral penicillin. These reactions are more apt to occur in individuals with a history of sensitivity to multiple allergens. If an allergic reaction occurs, appropriate measures should be instituted. Cross sensitivity between penicillin and cephalosporins is well documented. There are no effective and safe skin tests to predetermine an anaphylactoid reaction.
If an allergic reaction occurs, discontinue Amoxicillin 100 therapy and institute appropriate therapy. Serious anaphylactoid reactions require immediate emergency treatment with epinephrine. Oxygen, i.v. steroids and airway management, including intubation, should also be administered as indicated.
Pharyngitis or sore throat may cause refusal to eat. Acute allergic responses sensitized individuals include salivation, shivering, vomiting and urticaria, which may appear within 15 minutes after the second administration of penicillin and approximately 1 month after the first exposure. Many allergic responses subside a few hours.
SYMPTOMS AND TREATMENT OF OVERDOSAGE: Treatment of overdosage would likely be needed only in patients with severely impaired renal functions, since patients with normal kidneys excrete penicillin at a fast rate. Dialysis would, therefore, represent the main form of treatment.
Amoxicillin is stable in the presence of gastric acid and may be given with feed. It is rapidly and well absorbed after oral administration and diffuses readily into most body tissues and fluids, with the exception of brain and spinal fluid. The permeability of the meninges to penicillin in general is increased by inflammation. This may also apply to amoxicillin. It is excreted largely unchanged in the urine, but 10-25% is excreted in the form of penicilloic acid. Amoxicillin is not highly protein-bound. In blood serum, amoxicillin is only 17% protein-bound compared with 59% for penicillin G.
Dosage and Administration
To provide a dosage rate of 11 mg/kg twice daily, give to dogs weighing:
4.5 kg: 1/2 tablet
9 kg: 1 tablet
Give twice daily for 5-7 days. Continue administration for 48-72 hours after symptoms have subsided.
To provide a dosage rate of 11-22 mg/kg once daily, give to cats weighing:
under 2.25 kg: 1/4 tablet
2.25 kg: 1/4 to 1/2 tablet
4.5 kg: 1/2 to 1 tablet
over 4.5 kg: 1 tablet
Give once daily for 5-7 days. Continue administration for 48-72 hours after all symptoms have subsided.
Dogs And Cats
In severe urinary tract and gastrointestinal tract infections requiring high concentration, the above dosages should be doubled.
STORAGE CONDITIONS: Store in a dry place between 15 °C and 25 °C.
PRESENTATION: Amoxicillin -100 tablet is offered in bottle of 250 tablets (code 20124).
Vétoquinol N.-A. Inc., 2000, ch. Georges, Lavaltrie, QC, Canada J5T 3S5
NAC No.: 12341014
2000, CHEMIN GEORGES, LAVALTRIE, QC, J5T 3S5
|Every effort has been made to ensure the accuracy of the Amoxicillin 100 information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.|
Copyright © 2014 North American Compendiums. Updated: 2013-12-23