Veterinary Product Information
Vet > Adequan I.M. (Canada)
The information provided typically includes the following:
Manufacturer: Luitpold
LUITPOLD PHARMACEUTICALS, INC.
Distributed by CENTRAL SALES LTD.
14 REGAN RD., UNIT # 1, BRAMPTON, ON, L7A 1B9
Adequan I.M. (Canada)
This page contains information on Adequan I.M. for veterinary use.The information provided typically includes the following:
- Adequan I.M. Indications
- Warnings and cautions for Adequan I.M.
- Direction and dosage information for Adequan I.M.
Adequan I.m.
This treatment applies to the following species:
Manufacturer: Luitpold
Polysulfated Glycosaminoglycan Injection 100mg/ml
For Veterinary Use Only
For Intramuscular Use In Horses
Description
Each milliliter of Adequan® I.M. contains 100mg of Polysulfated Glycosaminoglycan (PSGAG) and Water for injection q.s. Sodium Hydroxide and/or Hydrochloric Acid added when necessary to adjust pH. Sodium Chloride may be added to adjust tonicity.Pharmacology
Polysulfated Glycosaminoglycan is chemically similar to the mucopolysaccharides of cartilaginous tissue. It is a potent proteolytic enzyme inhibitor and diminishes or reverses the processes which result in the loss of cartilaginous mucopolysaccharides. PSGAG improves joint function by stimulating synovial membrane activity, reducing synovial protein levels and increasing synovial fluid viscosity in traumatized equine joints.Toxicity
Toxicity studies were conducted in horses. Doses as high as 2,500mg were administered intramuscularly to 6 horses twice a week for 12 weeks or a total of 21 injections. This dosage is 5 times the recommended dosage and 3 times the recommended therapeutic regimen. Clinical observations revealed no soreness or swelling at the injection site or in the affected joint. No animal showed any evidence of abnormality that was related to Adequan® I.M. treatment as determined by clinical observation and a battery of laboratory tests.From 100,000 doses used clinically, the reported incidence of side effects is 0.001% (1 case). The reaction consisted of a transient joint flare, occurring within 24 hours of injection, and resolving within 24 hours with anti-inflammatory therapy.
Adequan I.M. Indications
Adequan® I.M. is recommended for the treatment of non-infectious degenerative and/or traumatic joint dysfunction and associated lameness in horses.Contraindications
Do not use Adequan® I.M. in horses demonstrating hypersensitivity to PSGAG.Warning
This drug is not to be administered to horses that are to be slaughtered for use in food.Adequan I.M. Dosage And Administration
The recommended dose of Adequan® I.M. is 500mg (1 vial) per 1000 lbs. body weight, given intramuscularly every 4 days for a total of 8 injections over a 28 day period. The injection site must be thoroughly cleansed prior to injection. Do not mix Adequan® I.M. with other drugs or solvents. For intramuscular use only - avoid inadvertent intravascular administration.Adverse Reactions
There are no known adverse reactions associated with the use of Adequan® I.M.Adequan I.M. Cautions
Avoid inadvertent intravascular administration. Not intended for use in breeding animals as effects on fertility and reproductive function in mares and stallions have not been studied.How Supplied
Adequan® I.M., 100mg/mL, is available as: 5mL glass vials, packaged in boxes of 4.Storage Conditions
Store at controlled room temperature 18º-25ºC (64º-77ºF).Discard unused portion.
LUITPOLD PHARMACEUTICALS, INC., Animal Health Division, Shirley, New York 11967
(800-458-0163)
REV. 6/90C
IN99501C
D.I.N. 01910051
Distributed by: Central Sales Ltd., Brampton, Ontario, Canada
Nac No.
11880020Distributed by CENTRAL SALES LTD.
14 REGAN RD., UNIT # 1, BRAMPTON, ON, L7A 1B9
| Telephone: | 905-840-0800 | |
| Order Desk: | 800-387-2522 | |
| Fax: | 905-840-1309 |
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Every effort has been made to ensure the accuracy of the Adequan I.M. information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Adequan I.M. product label or package insert. |
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