Medication Guide App

Acepromazine Maleate Tablets

This page contains information on Acepromazine Maleate Tablets for veterinary use.
The information provided typically includes the following:
  • Acepromazine Maleate Tablets Indications
  • Warnings and cautions for Acepromazine Maleate Tablets
  • Direction and dosage information for Acepromazine Maleate Tablets

Acepromazine Maleate Tablets

This treatment applies to the following species:
Manufacturer: Vedco

10 mg or 25 mg TABLETS

NADA 117-532, Approved by FDA

For use in dogs only

Contents: Each quarter scored tablet contains 10 mg or 25 mg acepromazine maleate.

Acepromazine Maleate Tablets Caution

Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.

Description

Acepromazine maleate, a potent neuroleptic agent with a low order of toxicity, is of particular value in the tranquilization of dogs. Its rapid action and lack of hypnotic effect are added advantages.

Chemistry: 2-acetyl-10-(3-dimethylaminopropyl) phenothiazine hydrogen maleate

ACEPROMAZINE MALEATE

Mode of Action: Acepromazine maleate has a depressant effect on the central nervous system and therefore causes sedation, muscular relaxation and a reduction in spontaneous activity. It acts rapidly, exerting a prompt and pronounced calming effect. It is an effective preanesthetic agent and lowers the dosage requirement of general anesthetics.

Toxicology: Acute and chronic toxicity studies have shown a very low order of toxicity for acepromazine maleate.

A safety study using elevated dosages of Acepromazine Maleate Tablets demonstrated no adverse reactions even when administered at three times the upper limit of the recommended daily dosage (3.0 mg/lb body weight). The clinical observation for this high dosage was mild depression which disappeared in most dogs 24 hours after termination of dosing.

The only occurrence of adverse reaction during numerous clinical trials was a very mild respiratory distress (reverse sneeze) which was transient in nature and had no effect on the desired action of the drug.

Acepromazine Maleate Tablets Indications

As an aid in tranquilization and as a preanesthetic agent in dogs.

Acepromazine Maleate Tablets can be used as an aid in controlling intractable animals during examination, treatment, grooming, x-ray and minor surgical procedures.

Contraindications

Phenothiazines may potentiate the toxicity of organophosphates. Therefore, do not use acepromazine maleate to control tremors associated with organic phosphate poisoning.

Do not use in conjunction with organophosphorus vermifuges or ectoparasiticides, including flea collars.

Do not use with procaine hydrochloride.

Warning

Federal law prohibits the use of this product in animals intended for human consumption.

Cautions: Tranquilizers are potent central nervous system depressants, and they can cause marked sedation with suppression of the sympathetic nervous system.

Tranquilizers can produce prolonged depression or motor restlessness when given in excessive amounts or when given to sensitive animals.

Tranquilizers are additive in action to the actions of other depressants and will potentiate general anesthesia. Tranquilizers should be administered in smaller doses and with greater care during general anesthesia and also to animals exhibiting symptoms of stress, debilitation, cardiac disease, sympathetic blockade, hypovolemia or shock. Acepromazine, like other phenothiazine derivatives, is detoxified in the liver; therefore, it should be used with caution on animals with a previous history of liver dysfunction or leukopenia.

Epinephrine is contraindicated for treatment of acute hypotension produced by phenothiazine-derivative tranquilizers since further depression of blood pressure can occur.

Phenothiazines should be used with caution when followed by epidural anesthetic procedures because they may potentiate the arterial hypotensive effects of local anesthetics.

A few rare but serious occurrences of idiosyncratic reactions to acepromazine may occur in dogs following oral or parenteral administration. These potentially serious adverse reactions include behavioral disorders in dogs such as aggression, biting/chewing, and nervousness.

Dosage and Administration

Dogs: 0.25-1.0 mg/lb of body weight. Dosage may be repeated as required.

How Supplied

Acepromazine Maleate Tablets are available in 10 & 25 mg concentrations, and are quarter scored for convenience of administration. Both concentrations are available in bottles of 100 and 500 tablets.

Keep out of reach of children

Distributed by: VEDCO, INC., St. Joseph, MO 64507

NET CONTENTS:

NDC

 

100 TABLETS (10 mg)

50989-206-51

670125L-00-9912

500 TABLETS (10 mg)

50989-206-52

670107L-00-9911

100 TABLETS (25 mg)

50989-207-51

670217L-00-0011

500 TABLETS (25 mg)

50989-207-52

670207L-00-9911

NAC No.: 10940022

VEDCO, INC.
5503 CORPORATE DR., ST. JOSEPH, MO, 64507
Telephone:   816-238-8840
Toll-Free:   888-708-3326 (888-70VEDCO)
Fax:   816-238-1837
Website:   www.vedco.com
Every effort has been made to ensure the accuracy of the Acepromazine Maleate Tablets information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2014 North American Compendiums. Updated: 2014-09-05

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