ZOLADEX LA 10.8MG DEPOT

Active substance: GOSERELIN ACETATE

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Patient Information Leaflet
®

Zoladex LA 10.8 mg Depot
(goserelin)
Read all of this leaflet carefully before you start using this
medicine.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor, nurse or
pharmacist.
• This medicine has been prescribed for you. Do not pass it on
to others. It may harm them, even if their symptoms are the
same as yours.
• If any of the side effects get serious, or if you notice any side
effects not listed in this leaflet, please tell your doctor, nurse or
pharmacist.

Take special care with Zoladex LA
Check with your doctor or nurse before you have Zoladex LA if:
• You have problems passing urine (water) or problems with
your back.
• You have diabetes.
• You have high blood pressure.
• You have any condition that affects the strength of your bones,
especially if you are a heavy drinker, a smoker, have a family
history of osteoporosis (a condition that affects the strength of
your bones) or take anticonvulsants (medicines for epilepsy or
fits) or corticosteroids (steroids).
There have been reports of depression in patients taking Zoladex
which may be severe. If you are taking Zoladex and develop
depressed mood, inform your doctor.
Medicines of this type can cause a reduction in bone calcium
(thinning of bones).

Your medicine is called Zoladex® LA 10.8 mg Depot but throughout
this leaflet will be referred to as Zoladex LA.

If you go into hospital, tell the medical staff that you are having
Zoladex LA.

In this leaflet:
1. What Zoladex LA is and what it is used for
2. Before you are given Zoladex LA
3. How Zoladex LA will be given
4. Possible side effects
5. How to store Zoladex LA
6. Further information

Taking other medicines
Please tell your doctor or nurse if you are taking or have recently
taken any other medicines. This includes medicines that you buy
without a prescription and herbal medicines.

1. What Zoladex LA is and what it is used for

Driving and using machines
Zoladex LA is not likely to affect you being able to drive or use any
tools or machines.
3. How Zoladex LA will be given

Zoladex LA contains a medicine called goserelin. This belongs to a
group of medicines called ‘LHRH analogues’.



Zoladex LA is used to treat prostate cancer. It works by reducing
the amount of ‘testosterone’ (a hormone) that is produced by your
body. Zoladex LA is a long-acting form of Zoladex and it is given
every 12 weeks.



2. Before you are given Zoladex LA
Do not have Zoladex LA if:
• You are allergic (hypersensitive) to goserelin or any of the
other ingredients of this medicine (listed in Section 6: Further
information).
• You are a woman
Do not have Zoladex LA if any of the above apply to you. If you are
not sure, talk to your doctor or pharmacist before having Zoladex
LA.
Zoladex LA should not be given to children.



The Zoladex LA will be injected under the skin on your
stomach every 12 weeks. This will be done by your doctor or
nurse.
It is important that you keep having Zoladex LA treatment,
even if you are feeling well.
Keep having this treatment until your doctor decides that it is
time for you to stop.

Your next appointment
• You should be given a Zoladex LA injection every 12 weeks.
• Always remind the doctor or nurse to set up an appointment
for your next injection.
• If you are given an appointment for your next injection which is
earlier or later than 12 weeks from your last injection, tell your
doctor or nurse.
• If it has been more than 12 weeks since your last injection,
contact your doctor or nurse so that you can receive your
injection as soon as possible.

4. Possible side effects
Like all medicines, Zoladex LA can cause side effects, although
not everybody gets them.
Allergic reactions:
These are rare. The symptoms can include sudden onset of:
• Rash, itching or hives on the skin.
• Swelling of the face, lips or tongue or other parts of the body.
• Shortness of breath, wheezing or trouble breathing.
If this happens to you, see a doctor straight away.

Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse.
This includes any possible side effects not listed in this leaflet.
You can also report side effects directly via the Yellow Card
Scheme at: www.mhra.gov.uk/yellowcard.
By reporting side effects, you can help provide more information
on the safety of this medicine.
5. How to store Zoladex LA


Your doctor may give you a prescription so that you can get
you medicine from the pharmacy and give it to your doctor
when you see him or her again.
Keep it in its original package and do not break the seal.
Do not store it above 25°C.
Keep it in a safe place where children cannot see it or reach it.
Your medicine should not be used after the expiry date on the
carton.
If your medicine is not used, take it back to your pharmacist.

Other possible side effects:
• Pain in your lower back or problems passing urine. If this
happens, talk to your doctor.
• Bone pain at the beginning of treatment. If this happens, talk
to your doctor.
• Hot flushes and sweating. Occasionally these side effects may
continue for some time (possibly months) after stopping
Zoladex LA.
• A reduced sex drive and impotence.
• Thinning of your bones.
• Rises in blood sugar levels.
• Tingling in your fingers or toes.
• Skin rashes.
• Hair loss.
• Weight gain.
• Pain, bruising, bleeding, redness or swelling where Zoladex LA
is injected.
• Pain in the joints.
• Reduced heart function or heart attack.
• Changes in blood pressure.
• Swelling and tenderness of your breasts.
• Changes in your mood (including depression).
• Changes in your blood.
• Liver problems.
• A blood clot in your lungs causing chest pain or shortness of
breath.
• Inflammation of the lungs. The symptoms may be like
pneumonia (such as feeling short of breath and coughing).
• Psychiatric problems called psychotic disorders which may
include hallucinations (seeing, feeling or hearing things that
are not there), disordered thoughts and personality changes.
This is very rare.
• The development of a tumour of the pituitary gland in your
head or, if you already have a tumour in your pituitary gland,
Zoladex LA may make the tumour bleed or collapse. These
effects are very rare. Pituitary tumours can cause severe
headaches, feeling or being sick, loss of eyesight and
becoming unconscious.






Do not be concerned by this list of possible side effects. You may
not get any of them.
If any of the side effects get serious, or if you notice any side
effects not listed in this leaflet, please tell your doctor, nurse or
pharmacist.

®is a registered trade mark of the AstraZeneca group of
companies



6. Further Information
6. Further information
What Zoladex LA 10.8 mg Depot contains
The active substance is goserelin. Each Zoladex LA 10.8 mg
Depot contains 10.8 mg of goserelin (as the acetate) in a long
acting sustained release implant. The other ingredient is
lactide/glycolide copolymer which is an inactive substance.
What Zoladex LA 10.8 Depot looks like and contents of the
pack
Zoladex LA is a Single Dose Safe System syringe applicator with a
protective sleeve in a sealed pouch which contains a desiccant
and is produced in packs of one injection.
Zoladex LA 10.8 Depot is produced in packs of one implant
(injection).
Manufactured by: AstraZeneca UK Limited, Silk Road Business
Park, Macclesfield, Cheshire, SK10 2NA, UK.
Procured from within the EU.
Product Licence Holder: Ecosse Pharmaceuticals Limited,
3 Young Place, East Kilbride G75 0TD.
Re-packaged by: Munro Wholesale Medical Supplies Limited,
3 Young Place, East Kilbride, G75 0TD.
PL 19065/0147

POM

This leaflet was revised on 20/08/2014
0147E-4

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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