ZANTAC EFFERVESCENT TABLETS 150MG

Active substance: RANITIDINE HYDROCHLORIDE

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Package Leaflet: Information for the User

Zantac Effervescent Tablets
150 mg and 300 mg
®

ranitidine hydrochloride
Read all of this leaflet carefully before
you start taking this medicine.
• Keep this leaflet. You may need to
read it again.
• If you have any further questions, ask
your doctor or pharmacist.
• This medicine has been prescribed for
you. Do not pass it on to others. It may
harm them, even if their symptoms are
the same as yours.
• If any of the side effects gets serious,
or if you notice any side effects not
listed in this leaflet, please tell your
doctor or pharmacist.
In this leaflet:
1 What Zantac is and what it is used for
2 Before you take Zantac
3 How to take Zantac Effervescent Tablets
4 Possible side effects
5 How to store Zantac
6 Further information

1 What Zantac is and
what it is used for
Zantac contains a medicine called
ranitidine. This belongs to a group of
medicines called H2-receptor antagonists.
It lowers the amount of acid in your
stomach.
For adults (including the elderly) Zantac
is used to:
• heal and stop ulcers in the stomach, or
the part of the gut it empties into (the
duodenum)
• help clear up infection in your stomach,
when taken with antibiotic medicines
(medicines taken to treat germs)
• stop stomach ulcers when they are a
side effect of some medicines
• stop ulcers from bleeding
• improve problems caused by acid in the
food pipe (oesophagus) or too much acid
in the stomach. Both of these can cause
pain or discomfort sometimes known as
‘indigestion’, ‘dyspepsia’ or ‘heartburn’
• stop acid coming up from the stomach
while under anaesthetic during an
operation.
For children (3 to 18 years) Zantac is used
to:
• heal ulcers in the stomach, of the part of
the gut it empties into (the duodenum)
• heal and stop problems caused by
acid in the food pipe (oesophagus) or
too much acid in the stomach. Both
of these can cause pain or discomfort
sometimes known as “indigestion”,
”dyspepsia” or “heartburn”.

2 Before you take Zantac
Do not take Zantac if:
• you are allergic (hypersensitive) to
ranitidine or any of the other ingredients
of Zantac (listed in Section 6).
If you are not sure, talk to your doctor or
pharmacist before taking Zantac.
Take special care with Zantac
Check with your doctor or pharmacist
before taking your medicine if:
• you have stomach cancer
• you have kidney problems. You will need
to take a different amount of Zantac
• you have had stomach ulcers before
and you are taking Non-Steroidal
Anti-Inflammatory (NSAID) medicines
• you have a rare condition called acute
porphyria
• you are over 65 years old
• you have lung disease
• you are diabetic
• you have any problems with your
immune system.
If you are not sure if any of the above
apply to you, talk to your doctor or
pharmacist before using this medicine.

Taking other
medicines
Please tell your
doctor or
pharmacist if
you are taking
or have recently
taken any other
medicines. This
includes medicines that you buy without a
prescription and herbal medicines. This is
because Zantac can affect the way some
other medicines work. Also some other
medicines can affect the way Zantac works.
In particular tell your doctor or pharmacist
if you are taking any of the following
medicines:
• Non-Steroidal Anti-Inflammatory (NSAID)
medicines, for pain and inflammation
• lidocaine, a local anaesthetic
• propranolol, procainamide or
n-acetylprocainamide, for heart problems
• diazepam, for worry or anxiety problems
• phenytoin, for epilepsy
• theophylline, for breathing problems
(asthma)
• warfarin, for thinning your blood
• glipizide, for lowering blood glucose
• atazanavir or delaviridine, for treating
HIV infection
• triazolam, for insomnia
• gefitnib, for lung cancer
• ketoconazole, an anti fungal medicine,
sometimes used for treating thrush.
Midazolam is a medicine that may be
given to you just before you have an
operation. Tell the doctor you are taking
Zantac before your operation in case he
or she wants to give you midazolam.
If you are not sure if any of the above
apply to you, talk to your doctor or
pharmacist before taking Zantac.
Pregnancy and breast-feeding
If you are pregnant, might become
pregnant or are breast-feeding, you
should not take this medicine unless your
doctor advises it is essential.
Ask your doctor or pharmacist for advice
before taking any medicine, if you are
pregnant or breast-feeding.
Important information about some
of the ingredients of Zantac
• Zantac Effervescent Tablets are
sweetened using a substance called
aspartame, which contains a source
of phenylalanine. If you have the rare
condition called phenylketonuria, talk to
your doctor before taking this medicine.
• Zantac also contains sodium (see Section
6 for the amount of sodium in each
tablet). This should be noted by patients
on a sodium restricted diet.

3 How to take Zantac
Effervescent Tablets
Always take Zantac exactly as your doctor
has told you. You should check with your
doctor or pharmacist if you are not sure.
Taking this medicine
• Take this medicine by mouth.
• Place the tablet(s) in half a glass of water.
• Allow the tablets to dissolve completely
in the water before you drink it.
The usual dose for an adult (including
the elderly) and adolescents (12 years and
over) is either:
• 150 mg in the morning and 150 mg
in the evening, or
• 300 mg at bedtime.
Your exact dose will depend on your
particular stomach condition, your doctor
will tell you the dose you should take.
Children over 30 kg of weight and from 3
to 11 years:
Your doctor will work out the right dose
for you based on your child’s weight.

Treatment of stomach or duodenal (small
intestine) ulcers:
The usual dose is 2 mg for each kg of
body weight, twice a day for four weeks.
This dose may be increased to 4 mg for

each kg, twice a day. Take each dose
about 12 hours apart. The duration of
treatment may be increased to 8 weeks.
Treatment of heartburn due to too much
acid:
The usual dose is 2.5 mg for each kg of
body weight, twice a day for two weeks.
This dose may be increased to 5 mg for
each kg, twice a day. Take each dose
about 12 hours apart.
If you take more Zantac than you should
Zantac is not normally harmful if you take
more than you should, unless:
• you take many tablets at once
• you are on a sodium restricted diet.
If any of the above apply to you (or
someone else taking this medicine),
you should go to your nearest hospital
casualty department straight away. Take
the medicine pack or any remaining
medicine with you so that the doctor
knows what you have taken.
If you forget to take Zantac
• If you forget a dose, take it as soon as
you remember it, unless it is nearly time
for your next dose.
• Do not take a double dose to make up
for a forgotten dose.
If you stop taking Zantac
After a few days of taking the tablets you
should start to feel much better. Do not
stop taking the tablets without talking to
your doctor or pharmacist first, otherwise
the original pain and discomfort may
come back.
If you have any further questions on the
use of this product, ask your doctor or
pharmacist.

4 Possible side effects
Like all medicines, Zantac can cause side
effects, although not everybody gets them.
The following side effects may happen
with this medicine.
Stop taking Zantac and see a doctor
straight away, if you notice any of the
following serious side effects, you may
need urgent medical treatment:
• allergic reactions, the signs may include:
- rash, itching or hives on the skin
- swelling of your face, lips, tongue or
other parts of the body
- chest pain, shortness of breath,
wheezing or having trouble breathing
- unexplained fever and feeling faint,
especially when standing up.
• kidney problems, which can lead to back
pain, fever, pain when passing urine, blood
in the urine and changes in blood tests.
• severe stomach pain, this may be a sign
of something called ‘pancreatitis’
• a slow or irregular heartbeat
Check with your doctor at your next visit
if you notice any of the following:
Common (affects less than 1 in 10 people)
• headache (sometimes severe)
• feeling dizzy
• diarrhoea.
Uncommon (affects less than 1 in 100
people)
• having blurred vision
• a rash on its own.
Check with your doctor as soon as
possible if you notice any of the following:
Very rare (affect less than 1 in 10,000
people)
• false results in blood tests called ‘liver
function tests’
• feeling depressed.

During post-marketing experience, the
following have been reported (unknown
frequency;
• there can be changes in the level of
certain substances in your blood. This
can lead to you feeling unusually tired
or short of breath and being more
likely to bruise or get an infection
• feeling confused, seeing or hearing
unexplained things (hallucinations)
• your joints or muscles are painful or
swollen or you cannot control their
movement
• your small blood vessels can become
swollen (known as ‘vasculitis’). Signs of
this can include: a rash, swollen joints
or kidney problems
• your liver can become swollen. This
can lead to: nausea (feeling sick) or
vomiting (being sick), loss of appetite
or generally feeling unwell, itching,
fever, yellowing of the skin and eyes or
dark coloured urine.
• flushing or marks on your skin that
look like targets
• unexplained hair loss
• impotence
• breast tenderness and/or breast
enlargement
• breast discharge.
If any of the side effects gets serious, or if
you notice any side effects not listed in this
leaflet, please tell your doctor or pharmacist.

5 How to store Zantac
• Keep out of the reach and sight of
children.
• Do not use Zantac after the expiry date
which is stated on the label. The expiry
date refers to the last day of that month.
• Do not store above 30°C.
• Store in a dry place.
• Medicines should not be disposed of via
household waste. Ask your pharmacist
how to dispose of medicines no longer
required. These measures will help to
protect the environment.

6 Further information
What Zantac contains:
• The active substance is ranitidine
(as the hydrochloride) 150 mg or 300 mg
• The other ingredients are sodium
bicarbonate, monosodium citrate,
povidone, sodium benzoate (E211),
orange and grapefruit flavouring and
a sweetener, aspartame.
• Each 150 mg tablet contains 328 mg
sodium. Each 300 mg tablet contains
479 mg sodium.
What Zantac looks like and contents
of the pack
Zantac Effervescent Tablets are round,
white to pale yellow tablets.
Cartons contain plastic (polypropylene)
tubes of 15 tablets. 150 mg strength
cartons contain 60 tablets and 300 mg
strength cartons contain 30 tablets.
Marketing Authorisation Holder
and Manufacturer
Product licence held by GlaxoSmithKline UK,
Stockley Park West, Uxbridge,
Middlesex UB11 1BT.
Manufactured by Glaxo Wellcome
Production, Zone Industrielle No. 2,
23 Rue Lavoisier, 27000 Evreux, France.
The information provided applies only to
Zantac Effervescent Tablets 150 mg and
300 mg.
Other formats:
To listen to or request a copy of this
leaflet in Braille, large print or audio
please call, free of charge:

0800 198 5000 (UK Only)

Please be ready to give the following
information:
Product name
Zantac Effervescent Tablets 150 mg
Zantac Effervescent Tablets 300 mg
Reference number
10949/0137
This is a service provided by the
Royal National Institute of the Blind.
Leaflet date: April 2009
Zantac is a registered trademark of the
GlaxoSmithKline group of companies
© 2009 GlaxoSmithKline group of
companies

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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