TRENTAL 400MG

Active substance: PENTOXIFYLLINE

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THE COLOURS SHOWN ON THIS PROOF ARE FOR GENERAL REPRESENTATION PURPOSES ONLY. THEY ARE NOT ACCURATE AND MUST NOT BE
USED AS A COLOUR MATCH FOR THE FINISHED JOB. PLEASE REFER TO THE PANTONE COLOUR GUIDES FOR ACCURATE COLOUR REFERENCES.

TRENTAL® 400mg TABLETS
(pentoxifylline)
Patient Information Leaflet

This product is known as the above name but will be referred to as Trental throughout this leaflet.

1. What Trental is and what it is used for
Trental contains a medicine called pentoxifylline.
This belongs to a group of medicines called peripheral vasodilators. It works by increasing the blood flow
to the arms and legs.
Trental can be used to treat:
• Peripheral vascular disease (poor circulation to the arms and legs).
• Intermittent claudication (pain on walking or at rest caused by poor circulation to the legs).

DATE:

Take special care with Trental
Check with your doctor or pharmacist before taking your medicine if:
• You feel dizzy, light-headed or faint when you stand or sit up too quickly (hypotension)
• You have problems with the blood supply to your heart caused by hardening or narrowing of the
arteries
• You have liver or kidney problems.
If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Trental.
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines.
This includes medicines you buy without a prescription, including herbal medicines. This is because
Trental can affect the way some other medicines work. Also some medicines can affect the way Trental
works.

DATE:
24/08/12
DATE OF PROOF:

In particular, tell your doctor if you are taking any of the following:
Trental may increase the effect of the following medicines:
• Medicines for diabetes including tablets or insulin
• Medicines for high blood pressure
• Anticoagulants such as warfarin.
When taken with Trental, the following medicines increase the chance of you getting side effects:
• Ketorolac used for pain relief
• Theophylline used to treat wheezing or difficulty in breathing.

TO UK PIL DATED MAY 2012

6464/0867A

Taking Trental with food and drink
Take Trental with or just after meals.

CODE:

DT
ARTWORKER:

WARNING!

2. Before you take Trental
Do not take Trental if:
• You are allergic (hypersensitive) to pentoxifylline, other similar medicines such as theophylline or
aminophylline or to any of the other ingredients of Trental (see Section 6: Further Information)
Signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your
lips, face, throat or tongue
• You have heart problems or have recently had a heart attack
• You have severe palpitations (very fast and uneven heartbeats)
• You have had a stroke with bleeding in the brain (cerebral haemorrhage)
• You have had bleeding in the eye (retinal haemorrhage).
Do not take this medicine if any of the above apply to you. If you are not sure, talk to your doctor or
pharmacist before taking Trental.

Pregnancy and breast-feeding
You should not take Trental if you are pregnant.
Ask your doctor or pharmacist for advice before taking any medicine.
If you are breast-feeding or planning to breast-feed, talk to your doctor or pharmacist before taking
Trental. This is because very small amounts may pass into the mothers’ milk.
Driving and using machines
You may feel dizzy while taking this medicine. If this happens, do not drive or use any tools or machines.
3. How to take Trental
Always take Trental exactly as your doctor has told you. You should check with your doctor or
pharmacist if you are not sure.
Taking this medicine
• If you feel the effect of your medicine is too weak or too strong, do not change the dose yourself,
but ask your doctor
• Take this medicine by mouth
• Swallow the tablets whole with a drink of water
• Take with or just after a meal.

Colour
Swatch

Black

WARNING!

ARIAL REGULAR FONT SIZE 8
ARIAL BOLD
FONT SIZE 8
BRIDGED TO
CRESTOR 6464/2069 2070

Notes:

CUSTOMER
APPROVED:
Q.A.
APPROVED:
05-0440
PRE-PRESS NO.:

CUSTOMER: Waymade
PRODUCT: Trental 400mg tabs

Read all of this leaflet carefully before you start taking this medicine
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their
symptoms are the same as yours.
• If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell
your doctor or pharmacist.
In this leaflet:
1. What Trental is and what it is used for
2. Before you take Trental
3. How to take Trental
4. Possible side effects
5. How to store Trental
6. Further information

PROOF HISTORY:
v.2 - waymade - 24/08/12

Leaflet Flat Size = 148 x 317

27mm

WE CANNOT ACCEPT RESPONSIBILITY FOR ANY ERRORS IN THIS PROOF AFTER APPROVAL. THE ARTWORK RECEIVED HAS BEEN SIGNIFICANTLY
ADJUSTED, REVISED OR RESET BY US FROM DISK OR HARD COPY. WHILST WE TAKE EXTREME CARE AT ALL TIMES TO ENSURE ACCURACY, THE FINAL RESPONSIBILITY
MUST BE TAKEN BY OUR CUSTOMER. IF YOU SIGN THIS PROOF YOU ARE SIGNIFYING FULL APPROVAL OF DESIGN AND TEXT.

000-0000A

THE COLOURS SHOWN ON THIS PROOF ARE FOR GENERAL REPRESENTATION PURPOSES ONLY. THEY ARE NOT ACCURATE AND MUST NOT BE
USED AS A COLOUR MATCH FOR THE FINISHED JOB. PLEASE REFER TO THE PANTONE COLOUR GUIDES FOR ACCURATE COLOUR REFERENCES.

Adults including the elderly
The usual starting dose is 1 tablet (400mg) three times a day. Your doctor may lower your dose to 1 tablet
twice a day.

If you forget to take Trental
Do not take a double dose to make up for a forgotten tablet.
If you stop taking Trental
Keep taking Trental until your doctor tells you to stop taking it.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
4. Possible side effects
Like all medicines, Trental can cause side effects, although not everybody gets them.

DATE:

Tell your doctor or pharmacist if any of the following side effects gets serious or lasts longer than
a few days. Also tell them if you notice any side effects not listed in this leaflet:
• Feeling sick (nausea) or being sick (vomiting), diarrhoea
• Headache, feeling dizzy, light-headed or faint
• Flushing
• Feeling agitated, sleep problems
• An illness where the removal of bile from the liver is blocked (intrahepatic cholestasis). Signs
include jaundice, rash or fever, and the colour of your water (urine) becomes darker
• Discomfort or bloating in the abdomen.

DATE:
24/08/12






5. How to store Trental
Trental 400mg tablets should be stored in a dry place below 25°C.
Do not use after the expiry date printed on the carton or blister label. The expiry date refers to the
last day of that month.
KEEP ALL MEDICINES OUT OF THE SIGHT AND REACH OF CHILDREN.
If your doctor tells you to stop taking the tablets, please take them back to the pharmacist for
safe disposal. Only keep the tablets if your doctor tells you to.
If the tablets become discoloured or show any other signs of deterioration, you should consult
your pharmacist who will advise you what to do.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist
how to dispose of medicines no longer required. These measures will help to protect the
environment.

TO UK PIL DATED MAY 2012

6464/0867A

6. Further Information
Your medicine is called Trental 400mg tablets. Each plain pink, oblong tablet contains 400mg of the active
ingredient pentoxifylline.

CODE:

ARTWORKER:

DT

DATE OF PROOF:



PRE-PRESS NO.:

Q.A.
APPROVED:

Blood tests
Trental can change the levels of liver enzymes shown up in blood tests. This can mean that your liver is
not working properly.

Trental 400mg tablets contain the following ingredients:
Hydroxyethylcellulose, talc, polyvinylpyrrolidone, magnesium stearate, hypromellose, titanium dioxide
(E171), benzyl alcohol, polyethylene glycol and erythrosine (E127).
Trental 400mg tablets are available as blister packs of 30 and 90 tablets.
POM

PL No: 6464/0867

This product is manufactured by Sanofi-Aventis S.p.A., S.S. n. 17, Km. 22 67019 Scoppito, Italy and is
procured from within the EU and repackaged by the Product Licence holder:
Waymade plc Miles Gray Road, Basildon, Essex SS14 3FR
Leaflet revision and issue date (Ref.) 24.8.2012
TRENTAL is a registered trademark of AVENTIS PHARMA DEUTSCHLAND GmbH

Colour
Swatch

Black

WARNING!

Tell your doctor as soon as possible if you have any of the following side effects:
• You bruise more easily than usual. This could be because of a blood disorder
(thrombocytopenia).
• Increased or fast heart beat (tachycardia)
• Chest pain (angina)
• Irregular heart beat (palpitations)




CUSTOMER: Waymade
PRODUCT: Trental 400mg tabs

WARNING!

Stop taking Trental and see your doctor or go to a hospital straight away if;
• If you have an allergic reaction. The signs may include: a rash, swallowing or breathing
problems, swelling of your lips, face, throat or tongue
• Bleeding under the skin
• Blood in your vomit or stools (motions)
• If you develop a condition called aseptic meningitis. Signs include headache, neck stiffness,
eye pain or discomfort in bright light.

WE CANNOT ACCEPT RESPONSIBILITY FOR ANY ERRORS IN THIS PROOF AFTER APPROVAL. THE ARTWORK RECEIVED HAS BEEN SIGNIFICANTLY
ADJUSTED, REVISED OR RESET BY US FROM DISK OR HARD COPY. WHILST WE TAKE EXTREME CARE AT ALL TIMES TO ENSURE ACCURACY, THE FINAL RESPONSIBILITY
MUST BE TAKEN BY OUR CUSTOMER. IF YOU SIGN THIS PROOF YOU ARE SIGNIFYING FULL APPROVAL OF DESIGN AND TEXT.

ARIAL REGULAR FONT SIZE 8
ARIAL BOLD
FONT SIZE 8
BRIDGED TO
CRESTOR 6464/2069 2070

Notes:

If you take more Trental than you should
If you take more tablets than you should, talk to a doctor or go to a hospital straight away. The following
effects may happen: low blood pressure, feeling sleepy, fits (seizures) or uneven heartbeat.

05-0440

CUSTOMER
APPROVED:

Patients with kidney problems
Your doctor may give you a lower dose if necessary.
Children
Trental is not suitable for use in children.

PROOF HISTORY:
v.2 - waymade - 24/08/12

Leaflet Flat Size = 148 x 317

27mm

Expand view ⇕

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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