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TIMOPTOL 0.5% UNIT DOSE OPHTHALMIC SOLUTION

Active substance: TIMOLOL MALEATE

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PACKAGE LEAFLET: INFORMATION FOR THE USER

Timoptol® 0.5% Unit Dose Ophthalmic Solution
(timolol maleate)
Read all of this leaflet carefully before you start using this medicine.
- Keep this leaflet. You may need to read it again.
- If you have any further questions, ask your doctor or pharmacist.
- This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their
symptoms are the same as yours.
- If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell
your doctor or pharmacist.

Instructions for use.
Open the drops container just before you want to use it. After using the drops, throw away what is left. This
is because the drops cannot be kept free of bacteria after being opened.
1. Open the foil sachet containing the individual single dose containers. There are three strips of 5 single
dose containers in each sachet.
2. First wash your hands and then break off a single dose container from the strip. Then twist open the top
of the single dose container as shown.
3. Tilt your head back and pull your lower eyelid now slightly

The name of your medicine is called Timoptol 0.5% Unit Dose Ophthalmic Solution, but will be referred to
as Timoptol throughout this leaflet. This product is also available as the 0.25% w/v strength.
In this leaflet:
1. What Timoptol is and what it is used for
2. Before you use Timoptol
3. How to use Timoptol
4. Possible side effects
5. How to store Timoptol
6. Further information

1

2

3

1. WHAT TIMOPTOL IS AND WHAT IT IS USED FOR
Timoptol contains a substance called timolol which belongs to a group of medicines called beta-blockers.
Timolol lowers the pressure in your eye(s). It is used to treat glaucoma, when the pressure in the eye is
raised.

2. BEFORE YOU USE TIMOPTOL
Do not use Timoptol if:

you are allergic (hypersensitive) to timolol maleate or any of the other ingredient of Timoptol (see
section 6 for Further Information).

you have now or have had in past respiratory problems such as asthma, severe chronic obstructive
bronchitis (severe lung disease which may cause wheeziness, difficulty in breathing and/or long
standing cough).

you have heart problems
- slow heart beat
- heart failure
- disorders of heart rhythm (irregular heart beats)
- “cardiogenic shock” – a serious heart condition caused by very low blood pressure, which may
result in the following symptoms: dizziness and lightheadedness, fast pulse rate, white skin,
sweating, restlessness, loss of consciousness
If you are not sure whether you should use Timoptol talk to your doctor or pharmacist.
Take special care with Timoptol
Before you use this medicine, tell your doctor if you have now or have had in the past

coronary heart disease – symptoms can include chest pain or tightness, breathlessness or choking,
heart failure, low blood pressure.

disturbances of the heart rate such as slow heart beat.

breathing problems, asthma or chronic obstructive pulmonary disease.

poor blood circulation disease (such as Raynaud’s disease or Raynaud’s syndrome)

diabetes as timolol may mask signs and symptoms of low blood sugar.

overactivity of the thyroid gland as timolol may mask signs and symptoms

allergies to any medicines

you wear soft contact lenses
If your eye becomes irritated or any new eye problems come on, talk to your doctor straight away. Eye
problems could include redness of the eye or swelling of the eyelids (see Section 4: Possible Side Effects).
If you suspect that Timoptol Unit Dose is causing an allergic reaction or hypersensitivity (for example, skin
rash, or redness and itching of the eye), stop using Timoptol Unit Dose and contact your doctor
immediately.
Tell you doctor if:
• you get an eye infection
• you injure your eye or have an operation on it
• your eye problems get worse or you get any new symptoms.
Tell your doctor before you have an operation that you are using Timoptol as timolol may change effects of
some medicines used during anaesthesia.
Use in children
Timoptol is not recommended for use in children and adolescents.
Using other medicines
Timoptol can affect or be affected by other medicines you are using, including other eye drops for the
treatment of glaucoma. Tell your doctor if you are using or intend to use medicines to lower blood pressure,
heart medicine or medicines to treat diabetes. Please tell your doctor of pharmacist if you are taking or
have recently taken any other medicines, including medicines obtained without a prescription.
It is important to tell your doctor before using Timoptol if you are taking one or more of the following
medicines:

a calcium antagonist, such as nifedipine, verapamil or diltiazem, often used to treat high blood
pressure, angina, an abnormal heartbeat or Raynaud’s syndrome

digoxin, a medicine used to relieve heart failure or treat abnormal heartbeat

medicines known as catecholamine-depleting agents, such as rauwolfia alkaloids/reserpine used for
high blood pressure

medicines called pressor amines, such as adrenaline used to treat severe allergic reaction

quinidine (used to treat heart conditions and some types of malaria),

antidepressants known as fluoxetine and paroxetine.

clonidine, a medicine used to treat high blood pressure

other beta-blockers taken by mouth or used as eye drops, because they belong to the same group of
medicines as Timoptol and could have an additive effect.
Pregnancy and breast-feeding
Do not use Timoptol if you are pregnant unless your doctor considers it necessary.
Do not use Timoptol if you are breast-feeding. Timolol may get into your milk.
Ask your doctor for advice before taking any medicine during breast-feeding.
Driving and using machines
There are possible side effects associated with Timoptol, such as dizziness and changes in your eyesight,
which may affect your ability to drive and/or operate machinery. Do not drive and/or operate machinery until
you feel well and your vision is clear.

3. HOW TO USE TIMOPTOL
Always use Timoptol exactly as your doctor has told you. Check with your doctor or pharmacist if you are
not sure. The doctor will decide how many drops you should use each day and how long you should use
them.
The usual dose is one drop in the affected eye(s) twice each day:

one in the morning

one in the evening.
Do not change the dose of this medicine without talking to your doctor.
Do not allow the tip of the single dose container to touch the eye or areas around the eye. It may become
contaminated with bacteria that can cause eye infection leading to serious damage of the eye, even loss of
vision. To avoid possible contamination of the single dose container, keep the tip of the single dose
container away from contact with any surface.

4. Put one drop in the affected eye(s) as directed by your doctor. Each single dose container contains
enough solution for both eyes.
5. After putting the drop into the eye(s), throw away the used container, even if there is solution
remaining, to avoid contamination.
6. Store the remaining containers in the foil sachet. The containers must be used within 15 days after
opening the sachet. If any containers are left 15 days after opening the sachet, throw them away and
open a new one.
Picture A
After using Timoptol, press a finger into the corner of your eye,
by the nose (Picture A) for 2 minutes.
This helps to stop timolol getting into the rest of the body.
If you use more Timoptol than you should
If you put too many drops in your eye or swallow any of the drops, you may:

have a headache

feeling dizzy or light-headed

have difficulty breathing

feel that your heart rate has slowed down.
If this happens, contact your doctor immediately.
If you forget to use Timoptol
It is important to use Timoptol as prescribed by your doctor.

If you miss a dose, use the drops as soon as possible.

If it is almost time for the next dose, skip the missed dose and use the next dose at the usual time.

Do not use a double dose to make up for the forgotten dose.
If you stop using Timoptol
If you want to stop using this medicine talk to your doctor first. If you have any further questions on the use
of this product, ask your doctor or pharmacist.

4. POSSIBLE SIDE EFFECTS
Like all medicines Timoptol can cause side effects, although not everybody gets them. If they do occur, you
may need medical attention. In some patients these may include:
Allergic reactions

allergic skin rash and hives

severe allergic reaction which causes difficulty in breathing or dizziness.
Eye and ears

burning and stinging

dry eyes

irritation and redness of your eye or eyelid

sensitivity to light

discharge from the eye

visual changes such as double vision

decreased sensation of your eye surface

pain in your eye

drooping eyelid

ringing in your ears.
Heart and circulation

chest pain

heart attack

fainting

palpitations

an irregular heartbeat

a slowing of your heart rate

low blood pressure

interference with your blood supply to the brain which may lead to a stroke

too much fluid, mainly water, accumulating in your body

limping because there is a reduced blood supply to your legs

swelling or coldness of your hands, feet and extremities, caused by constriction of the blood vessels.
Chest

wheezing

shortness of breath

difficulty breathing

cough.
Stomach and gut

nausea

diarrhoea

indigestion

vomiting

dry mouth.
Sexual

decreased sex drive

in men a condition which effects your penis called Peyronie’s disease. The signs may be abnormal
curve, pain or hardening of the tissue of your penis.
Skin and hair

hair loss

a skin disease called psoriasis, where areas of skin such as knees and elbows are covered in scales

worsening of psoriasis.
Nervous system

dizziness

depression

unable to sleep

nightmares

memory loss

increase in signs and symptoms of myasthenia gravis

tingling sensation.

General

headache

tiredness

weakness

a condition called lupus (systemic lupus erythematosus).
Like other medicines applied into eyes, timolol is absorbed into the blood. This may cause similar side
effects as seen with ‘intraveneous' and/or 'oral' as applicable beta-blocking agents. Incidence of side
effects after topical ophthalmic administration is lower than when medicines are, for example, taken by
mouth or injected. Listed side effects include reactions seen within the class of beta-blockers when used for
treating eye conditions:
-

Generalised allergic reactions including swelling beneath the skin face and limbs, and can obstruct the airway which may cause difficulty swallowing or breathing.>, hives
, localized and generalized rash, itchiness, severe sudden life-threatening allergic
reaction.

-

Low blood glucose levels.

-

Difficulty sleeping (insomnia), depression, nightmares, memory loss.

-

Fainting, stroke, reduced blood supply to the brain, increases in signs and symptoms of myasthenia
gravis (muscle disorder), dizziness, unusual sensations , and headache.

-

Signs and symptoms of eye irritation (e.g. burning, stinging, itching, tearing, redness), inflammation of
the eyelid, inflammation in the cornea, blurred vision and detachment of the layer below the retina that
contains blood vessels following filtration surgery which may cause visual disturbances, decreased
corneal sensitivity, dry eyes, corneal erosion (damage to the front layer of the eyeball), drooping of the
upper eyelid (making the eye stay half closed), double vision.

-

Slow heart rate, chest pain, palpitations, oedema (fluid build up), changes in the rhythm or speed of the
heartbeat, congestive heart failure (heart disease with shortness of breath and swelling of the feet and
legs due to fluid build up), a type of heart rhythm disorder, heart attack, heart failure.

-

Low blood pressure, Raynaud's phenomenon, cold hands and feet.

-

Constriction of the airways in the lungs (predominantly in patients with pre-existing disease), difficulty
breathing, cough.

-

Taste disturbances, nausea, indigestion, diarrhoea, dry mouth, abdominal pain, vomiting.

-

Hair loss, skin rash with white silvery coloured appearance (psoriasiform rash) or worsening of
psoriasis, skin rash.

-

Muscle pain not caused by exercise.

-

Sexual dysfunction, decreased libido.

-

Muscle weakness/tiredness.

Ask your doctor or pharmacist for more information about the side effects. Both have a more complete list
of side effects.
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell
your doctor or pharmacist.

5. HOW TO STORE TIMOPTOL UNIT DOSE
Keep your eye drops out of the sight and reach of children.
Do not store above 25°C and keep in outer carton.
If you have any unit dose containers left when your doctor tells you to stop using them, return them to your
pharmacist.
WARNING: If the solution become discoloured or show any signs of deterioration seek the advice of your
pharmacist.
Do not use them if they are past the expiry date which is clearly marked on the box.
Remember, this medicine is for you. Do not share it with anyone else. It may not suit them.

6. FURTHER INFORMATION
What Timoptol contains
Timoptol 0.5% Unit Dose Ophthalmic Solution is available as 0.5% w/v solution of timolol maleate.
Other Ingredients:
Sodium phosphate monobasic, sodium phosphate dibasic, sodium hydroxide and water for injections.
What Timoptol looks like and contents of the pack
Timoptol 0.5% Unit Dose Ophthalmic solution is a clear, colourless to light yellow, sterile eye drops
solution.
Timoptol 0.5% Unit Dose Ophthalmic Solution is available in cartons containing 30 unit doses.
Each Timoptol 0.5% Unit Dose Ophthalmic Solution dispenser contains 0.20 ml.
Manufactured by: Laboratories Merck Sharp & Dohme – Chibret, Mirabel Plant, Route de Marsat,
63203 Riom Cedex, France.
Procured from within the EU and repackaged by the Product Licence holder: B&S Healthcare,
Unit 4, Bradfield Road, Ruislip, Middlesex, HA4 0NU, UK
Timoptol 0.5% Unit Dose Ophthalmic Solution - PL No: 18799/1437

POM

Leaflet date: 02.07.2012
Timoptol is registered trademark of Merck & Co., Inc., Whitehouse Station, NJ, USA

PACKAGE LEAFLET: INFORMATION FOR THE USER

Timolol 0.5% Unit Dose Ophthalmic Solution
(timolol maleate)
Read all of this leaflet carefully before you start using this medicine.
- Keep this leaflet. You may need to read it again.
- If you have any further questions, ask your doctor or pharmacist.
- This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their
symptoms are the same as yours.
- If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell
your doctor or pharmacist.

Instructions for use.
Open the drops container just before you want to use it. After using the drops, throw away what is left. This
is because the drops cannot be kept free of bacteria after being opened.
1. Open the foil sachet containing the individual single dose containers. There are three strips of 5 single
dose containers in each sachet.
2. First wash your hands and then break off a single dose container from the strip. Then twist open the top
of the single dose container as shown.
3. Tilt your head back and pull your lower eyelid now slightly

The name of your medicine is called Timolol 0.5% Unit Dose Ophthalmic Solution, but will be referred to as
Timoptol throughout this leaflet. This product is also available as the 0.25% w/v strength.
In this leaflet:
1. What Timolol is and what it is used for
2. Before you use Timolol
3. How to use Timolol
4. Possible side effects
5. How to store Timolol
6. Further information

1. WHAT TIMOLOL IS AND WHAT IT IS USED FOR
Timoptol contains a substance called timolol which belongs to a group of medicines called beta-blockers.
Timolol lowers the pressure in your eye(s). It is used to treat glaucoma, when the pressure in the eye is
raised.

2. BEFORE YOU USE TIMOLOL
Do not use Timolol if:

you are allergic (hypersensitive) to timolol maleate or any of the other ingredients of Timolol (see
section 6 for Further Information)

you have respiratory disease, such as asthma, a history of asthma or chronic obstructive lung disease

you have heart problems
- slow or irregular heart beat
- heart failure
- disorders of heart rhythm (irregular heart beats)
- “cardiogenic shock” – a serious heart condition caused by very low blood pressure, which may result
in the following symptoms: dizziness and lightheadedness, fast pulse rate, white skin, sweating,
restlessness, loss of consciousness
If you are not sure whether you should use Timolol talk to your doctor or pharmacist.
Take special care with Timolol
Before you use this medicine, tell your doctor if you have now or have had in the past

coronary heart disease – symptoms can include chest pain or tightness, breathlessness or choking,
heart failure, low blood pressure.

disturbances of the heart rate such as slow heart beat.

breathing problems, asthma or chronic obstructive pulmonary disease.

poor blood circulation disease (such as Raynaud’s disease or Raynaud’s syndrome)

diabetes as timolol may mask signs and symptoms of low blood sugar.

overactivity of the thyroid gland as timolol may mask signs and symptoms

allergies to any medicines

you wear soft contact lenses

1

2

3

4. Put one drop in the affected eye(s) as directed by your doctor. Each single dose container contains
enough solution for both eyes.
5. After putting the drop into the eye(s), throw away the used container, even if there is solution
remaining, to avoid contamination.
6. Store the remaining containers in the foil sachet. The containers must be used within 15 days after
opening the sachet. If any containers are left 15 days after opening the sachet, throw them away and
open a new one.
Picture A
After using Timolol, press a finger into the corner of your eye,
by the nose (Picture A) for 2 minutes.
This helps to stop timolol getting into the rest of the body.
If you use more Timolol than you should
If you put too many drops in your eye or swallow any of the drops, you may:

have a headache

feeling dizzy or light-headed

have difficulty breathing

feel that your heart rate has slowed down.
If this happens, contact your doctor immediately.
If you forget to use Timolol
It is important to use Timolol as prescribed by your doctor.

If you miss a dose, use the drops as soon as possible.

If it is almost time for the next dose, skip the missed dose and use the next dose at the usual time.

Do not use a double dose to make up for the forgotten dose.
If you stop using Timolol
If you want to stop using this medicine talk to your doctor first. If you have any further questions on the use
of this product, ask your doctor or pharmacist.

4. POSSIBLE SIDE EFFECTS
Like all medicines Timolol can cause side effects, although not everybody gets them. If they do occur, you
may need medical attention. In some patients these may include:
Allergic reactions
allergic skin rash and hives

severe allergic reaction which causes difficulty in breathing or dizziness.

If your eye becomes irritated or any new eye problems come on, talk to your doctor straight away. Eye
problems could include redness of the eye or swelling of the eyelids (see Section 4: Possible Side Effects).



If you suspect that Timolol is causing an allergic reaction or hypersensitivity (for example, skin rash, or
redness and itching of the eye), stop using Timolol and contact your doctor immediately.

Eye and ears

burning and stinging

dry eyes

irritation and redness of your eye or eyelid

sensitivity to light

discharge from the eye

visual changes such as double vision

decreased sensation of your eye surface

pain in your eye

drooping eyelid

ringing in your ears.

Tell you doctor if:
• you get an eye infection
• you injure your eye or have an operation on it
• your eye problems get worse or you get any new symptoms.
Use in children
Timolol is not recommended for use in children and adolescents.
Using other medicines
Timolol can affect or be affected by other medicines you are using, including other eye drops for the
treatment of glaucoma. Tell your doctor if you are using or intend to use medicines to lower blood pressure,
heart medicine or medicines to treat diabetes. Please tell your doctor of pharmacist if you are taking or
have recently taken any other medicines, including medicines obtained without a prescription.
It is important to tell your doctor before using Timolol if you are taking one or more of the following
medicines:

a calcium antagonist, such as nifedipine, verapamil or diltiazem, often used to treat high blood
pressure, angina, an abnormal heartbeat or Raynaud’s syndrome

digoxin, a medicine used to relieve heart failure or treat abnormal heartbeat

medicines known as catecholamine-depleting agents, such as rauwolfia alkaloids/reserpine used for
high blood pressure

medicines called pressor amines, such as adrenaline used to treat severe allergic reaction

quinidine (used to treat heart conditions and some types of malaria),

antidepressants known as fluoxetine and paroxetine.

clonidine, a medicine used to treat high blood pressure

other beta-blockers taken by mouth or used as eye drops, because they belong to the same group of
medicines as Timolol and could have an additive effect.
Pregnancy and breast-feeding
Do not use Timolol if you are pregnant unless your doctor considers it necessary.
Do not use Timolol if you are breast-feeding. Timolol may get into your milk.
Ask your doctor for advice before taking any medicine during breast-feeding.
Driving and using machines
There are possible side effects associated with Timolol, such as dizziness and changes in your eyesight,
which may affect your ability to drive and/or operate machinery. Do not drive and/or operate machinery until
you feel well and your vision is clear.

3. HOW TO USE TIMOLOL
Always use Timolol exactly as your doctor has told you. Check with your doctor or pharmacist if you are not
sure. The doctor will decide how many drops you should use each day and how long you should use them.
The usual dose is one drop in the affected eye(s) twice each day:

one in the morning

one in the evening.
Do not change the dose of this medicine without talking to your doctor.
Do not allow the tip of the single dose container to touch the eye or areas around the eye. It may become
contaminated with bacteria that can cause eye infection leading to serious damage of the eye, even loss of
vision. To avoid possible contamination of the single dose container, keep the tip of the single dose
container away from contact with any surface.

Heart and circulation

chest pain

heart attack

fainting

palpitations

an irregular heartbeat

a slowing of your heart rate

low blood pressure

interference with your blood supply to the brain which may lead to a stroke

too much fluid, mainly water, accumulating in your body

limping because there is a reduced blood supply to your legs

swelling or coldness of your hands, feet and extremities, caused by constriction of the blood vessels.
Chest

wheezing

shortness of breath

difficulty breathing

cough.
Stomach and gut

nausea

diarrhoea

indigestion

vomiting

dry mouth.
Sexual

decreased sex drive

in men a condition which effects your penis called Peyronie’s disease. The signs may be abnormal
curve, pain or hardening of the tissue of your penis.
Skin and hair

hair loss

a skin disease called psoriasis, where areas of skin such as knees and elbows are covered in scales

worsening of psoriasis.
Nervous system

dizziness

depression

unable to sleep

nightmares

memory loss

increase in signs and symptoms of myasthenia gravis

tingling sensation.
General

headache

tiredness

weakness

a condition called lupus (systemic lupus erythematosus).

Like other medicines applied into eyes, timolol is absorbed into the blood. This may cause similar side
effects as seen with ‘intraveneous' and/or 'oral' as applicable beta-blocking agents. Incidence of side
effects after topical ophthalmic administration is lower than when medicines are, for example, taken by
mouth or injected. Listed side effects include reactions seen within the class of beta-blockers when used for
treating eye conditions:
-

Generalised allergic reactions including swelling beneath the skin face and limbs, and can obstruct the airway which may cause difficulty swallowing or breathing.>, hives
, localized and generalized rash, itchiness, severe sudden life-threatening allergic
reaction.

-

Low blood glucose levels.

-

Difficulty sleeping (insomnia), depression, nightmares, memory loss.

-

Fainting, stroke, reduced blood supply to the brain, increases in signs and symptoms of myasthenia
gravis (muscle disorder), dizziness, unusual sensations , and headache.

-

Signs and symptoms of eye irritation (e.g. burning, stinging, itching, tearing, redness), inflammation of
the eyelid, inflammation in the cornea, blurred vision and detachment of the layer below the retina that
contains blood vessels following filtration surgery which may cause visual disturbances, decreased
corneal sensitivity, dry eyes, corneal erosion (damage to the front layer of the eyeball), drooping of the
upper eyelid (making the eye stay half closed), double vision.

-

Slow heart rate, chest pain, palpitations, oedema (fluid build up), changes in the rhythm or speed of the
heartbeat, congestive heart failure (heart disease with shortness of breath and swelling of the feet and
legs due to fluid build up), a type of heart rhythm disorder, heart attack, heart failure.

-

Low blood pressure, Raynaud's phenomenon, cold hands and feet.

-

Constriction of the airways in the lungs (predominantly in patients with pre-existing disease), difficulty
breathing, cough.

-

Taste disturbances, nausea, indigestion, diarrhoea, dry mouth, abdominal pain, vomiting.

-

Hair loss, skin rash with white silvery coloured appearance (psoriasiform rash) or worsening of
psoriasis, skin rash.

-

Muscle pain not caused by exercise.

-

Sexual dysfunction, decreased libido.

-

Muscle weakness/tiredness.

Ask your doctor or pharmacist for more information about the side effects. Both have a more complete list
of side effects.
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell
your doctor or pharmacist.

5. HOW TO STORE TIMOLOL
Keep your eye drops out of the sight and reach of children.
Do not store above 25°C and keep in outer carton.
If you have any unit dose containers left when your doctor tells you to stop using them, return them to your
pharmacist.
WARNING: If the solution become discoloured or show any signs of deterioration seek the advice of your
pharmacist.
Do not use them if they are past the expiry date which is clearly marked on the box.
Remember, this medicine is for you. Do not share it with anyone else. It may not suit them.

6. FURTHER INFORMATION
What Timolol contains
Timolol 0.5% Unit Dose Ophthalmic Solution is available as 0.5% w/v solution of timolol maleate.
Other Ingredients:
Sodium phosphate monobasic, sodium phosphate dibasic, sodium hydroxide and water for injections.
What Timolol looks like and contents of the pack
Timolol 0.5% Unit Dose Ophthalmic solution is a clear, colourless to light yellow, sterile eye drops solution.
Timolol 0.5% Unit Dose Ophthalmic Solution is available in cartons containing 30 unit doses.
Each Timolol 0.5% Unit Dose Ophthalmic Solution dispenser contains 0.20 ml.
Manufactured by: Laboratories Merck Sharp & Dohme – Chibret, Mirabel Plant, Route de Marsat,
63203 Riom Cedex, France.
Procured from within the EU and repackaged by the Product Licence holder: B&S Healthcare,
Unit 4, Bradfield Road, Ruislip, Middlesex, HA4 0NU, UK
Timolol 0.5% Unit Dose Ophthalmic Solution - PL No: 18799/1437
Leaflet date: 02.07.2012

POM

Expand view ⇕

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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