TIMODINE CREAM

Active substance: NYSTATIN

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Timodine Cream PIL 11-106 10-10-11_- 10/10/2011 13:06 Page 2

PATIENT INFORMATION LEAFLET

Timodine Cream
®

ALLIANCE

Read all of this leaflet carefully before you start using this medicine
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as
yours.
• If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet please tell your doctor or pharmacist.
The information in this leaflet has been divided into the following sections:
1. What Timodine Cream is and what it is used for
2. Check before you use Timodine Cream
3. How to use Timodine Cream
4. Possible side effects
5. How to store Timodine Cream
6. Further information
1. What Timodine Cream is and what it is used for
Timodine Cream is used to treat inflamed skin conditions, particularly where the fungal infection Candida albicans can occur.
Timodine Cream contains four different medicines called nystatin, hydrocortisone, dimeticone and benzalkonium chloride.
• Nystatin is an antifungal agent which kills Candida albicans
• Hydrocortisone is a mild corticosteroid (or steroid) which fights the inflammation that causes redness, swelling and itchiness
• Dimeticone is a water-repellent which stops wetting and chafing
• Benzalkonium chloride is an antiseptic which kills bacteria.
Where two folds of skin rub together, chafing can occur, leading to a sore inflamed area of skin. This particularly happens in places such
as the groin or under the breasts where frequent sweating occurs. This combination of irritated skin and wetness is called intertrigo. The
same condition happens under babies’ nappies and is known as nappy rash. In both intertrigo and nappy rash the inflamed skin is easily
infected by germs, in particular a fungus called Candida albicans. Timodine Cream is specially formulated to ease the soreness and treat
the infections in intertrigo and inflamed nappy rash.
Timodine Cream can also be used to treat the following skin conditions when there is infection with Candida albicans:
• Eczema
• Housewives hands (skin irritation caused by chemicals such as washing powders)
• Seborrhoeic dermatitis (inflammation of the scalp with excessive dandruff scales and oily secretions)
• Pruritis ani and vulvae (irritation of the external area around the anus and vagina).
2. Check before you use Timodine Cream
Do not use Timodine Cream on you or your child:
• if you or your child are allergic (hypersensitive) to nystatin, hydrocortisone, dimeticone 350, benzalkonium chloride solution or any of
the ingredients in Timodine Cream (see Section 6 Further Information)
• on any untreated bacterial, fungal or viral skin infections
• on ulcerated skin
• to treat a skin condition called perioral dermatitis. This is a red spotty rash around your mouth or chin
• to treat a skin condition called rosacea. This is redness and inflammation over your nose, cheeks, chin or forehead
• near the eyes
• under dressings on large areas of the body.
Do not use Timodine Cream for longer than 7 days on infants unless your doctor tells you to
If any of the above applies to you, or if you are not sure, speak to your doctor or pharmacist before you use Timodine Cream.
Take special care with Timodine Cream
• Ask your doctor before using Timodine Cream:
− if you are pregnant or breast feeding
− if you are elderly
− if using on a newborn baby
− if you or your child have pruritis (an itchy skin condition)
− if you or your child have liver disease
− on infected wounds, broken skin, thin/ raw skin or acne
• Avoid prolonged use of Timodine Cream on the face
• Prolonged use of Timodine Cream could increase the likelihood of the cream stopping being effective for you, and of you developing
an allergic reaction to the cream
• Increased absorption of the cream may occur if the cream is used on thin/ raw skin, on areas where two skin areas touch or rub
together, or under dressings. Thinning of the skin is more likely to occur if the cream is used under dressings
• If you are using Timodine Cream for nappy rash make sure you speak to your doctor about how you should use the cream. Nappies
can make it easier for the ingredients of the cream to pass through the skin and it is possible to accidently end up using too much cream.
If any of the above applies to you, or if you are not sure, speak to your doctor or pharmacist before you use Timodine Cream.
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken/used any other medicines, including medicines obtained
without a prescription.
If you are using other skin creams at the same time as Timodine Cream, make sure you leave several minutes between applying the
different creams.
Pregnancy and breast-feeding
Ask your doctor or pharmacist for advice before taking any medicine.
There is not enough information to show that Timodine Cream can be used safely during pregnancy and breast-feeding. If you are
pregnant or breast-feeding, only use Timodine Cream if advised by your doctor.
Important information about some of the ingredients of Timodine Cream
Timodine Cream contains:
• Butylated hydroxyanisole (E320) – which may cause local skin reactions (e.g. rash, itching or redness), or irritation to the eyes and
mucous membranes
• Cetostearyl alcohol and sorbic acid – both of these ingredients may cause local skin reactions (e.g. rash, itching or redness)
• Propyl hydroxybenzoate (E216) and methyl hydroxybenzoate (E218) – both of these ingredients may cause allergic reactions (possibly
delayed).
3. How to use Timodine Cream
Always use Timodine Cream exactly as your doctor has told you to. You should check with your doctor or pharmacist if you are not sure.
A finger-tip length of cream should be enough for each inflamed area. It is important to apply the cream thinly, to the affected area only.

CONFORMA
Item Code:

Proof number:

0904-619

04

Product Description: ..................................... TIMODINE

Languages: ......................................................
Dimensions (mm): ...................................... 265 x 160

Folded (mm):................................ 23- 2 x 160
Text size (body text):..................................................

Created:........................ INDESIGN CS5

Pharmacode:........................................ 14001

Visual code:..................................................

PG number:...............................300042 000

Date:...............................05 dec 2011

Contact:.................Didier Vandenabeele
Colours used:

Black

Front

PMSxxx PMSxxx PMSxxx PMSxxx

Approved by
Signature

Approval Date

For intertrigo, eczema, housewives’ hands, seborrhoeic dermatitis, pruritis ani and vulvae:
Apply a thin layer of Timodine Cream to the sore area and rub into the skin gently until the cream disappears. Repeat the treatment three
times a day until the skin is healed.
For severe nappy rash: Remove the soiled nappy, then clean and dry your baby’s skin. Rub a thin layer of Timodine Cream into the sore
areas until the cream disappears. Repeat the treatment after every nappy change.
• Do not use Timodine Cream for more than 7 days, unless your doctor tells you to.
You may find a yellow stain on terry cotton nappies after using Timodine Cream. This will disappear after soaking in bleach or nappy
solution followed by rinsing and normal washing.
If you use more Timodine Cream than you should
Over-use of any corticosteroid cream can result in:
• irreversible skin thinning, stretch marks, and dilated blood vessels near the surface of the skin
• the body absorbing too much steroid and the adrenal glands may stop working properly. Symptoms of this may include tiredness,
depression and anxiety
• a condition where levels of steroid hormone become too high in the body, known as Cushing’s syndrome. Symptoms include a puffy
and rounded face that is also red, stretch marks and acne.
Timodine Cream is for external use only and should only be applied to the skin. If you accidently swallow the cream this may cause
nausea and vomiting or diarrhoea. If the cream is swallowed, drinking a glass of water or milk may be helpful. You should tell your doctor
at once or contact your nearest accident and emergency department. Show any left-over medicines or the empty container to your doctor.
If you forget to use Timodine Cream
In the case of a missed application, simply apply when the next dose is due.
If you stop using Timodine Cream
A worsening of symptoms can sometimes occur. If this happens to you, tell your doctor or pharmacist.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
4. Possible side effects
Do not worry. Like all medicines, Timodine Cream can cause side effects, although not everybody gets them.
Some people may be allergic to Timodine Cream. If you or your child experience an allergic reaction you should stop using Timodine
Cream and tell your doctor straight away or contact the accident and emergency department of your nearest hospital. Signs of an allergic
reaction may include:
• severe rash
• swallowing or breathing problems
• swelling of your lips, face, throat or tongue
• weakness, feeling dizzy or faint
• nausea.
Other possible side effects:
• thinning of the skin
• stretch marks
• dilated blood vessels near the surface of the skin
• red spotty rash around your mouth or chin
• acne, or your acne may become worse
• allergic or irritant skin reactions
• loss of colour in the skin where the cream is used
• excessive hair growth
• the appearance of red or purple discolorations on the skin that do not blanch on applying pressure
• spread and worsening of untreated infection
• redness and inflammation over the nose, cheeks, chin or forehead
• adrenal glands may stop working properly. Symptoms of this may include tiredness, depression and anxiety
• Cushing’s syndrome (a condition where levels of steroid hormone become too high in the body). Symptoms include a puffy and
rounded face that is also red, stretch marks and acne.
If you or your child experience any of the above side effects, or if you notice any side effects not listed in this leaflet, please tell your
doctor or pharmacist.
5. How to store Timodine Cream
Keep out of the reach and sight of children.
Do not use Timodine Cream after the expiry date which is stated on the carton and on the tube (EXP). The expiry date refers to the last
day of that month.
Store Timodine Cream below 15˚C.
Do not use Timodine Cream if you notice a change in the colour or feel of the cream.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist on how to dispose of medicines no longer
required. These measures will help protect the environment.
6. Further information
What is in Timodine Cream?
The active ingredients in this medicine are nystatin 100,000 IU/g, hydrocortisone 0.5% w/w, dimeticone 350 10% w/w and benzalkonium
chloride solution 0.2% w/w.
The other ingredients are dibutyl phthalate, glyceryl monostearate SE, purified water, stearic acid, sodium metabisulphite, cellulose nitrate,
cetostearyl alcohol, butylated hydroxyanisole compound (containing butylated hydroxyanisole (E320), propyl gallate and citric acid),
methyl hydroxybenzoate (E218), propyl hydroxybenzoate (E216), and sorbic acid.
What Timodine Cream looks like and contents of the pack
Timodine Cream is a pale yellow cream.
Timodine Cream comes in aluminium tubes of 5.5g, 7.5g and 30g. Not all pack sizes may be marketed.
Marketing Authorisation Holder and Manufacturer
The marketing authorisation holder is: Alliance Pharmaceuticals Ltd, Avonbridge House, Bath Road, Chippenham, Wiltshire, SN15 2BB,
UK.
Timodine Cream is manufactured by: Conforma N.V., Zenderstraat 10, B-9070 Destelbergen, Belgium.
The information in this leaflet applies only to Timodine Cream. If you have any questions or you are not sure about anything, ask your
doctor or a pharmacist.
This leaflet was last revised in November 2011
Timodine is a registered trademark of Alliance Pharmaceuticals Ltd.
Alliance and associated devices are registered trademarks of Alliance Pharmaceuticals Ltd.
© Alliance Pharmaceuticals Ltd 2011
0904-619

014001

CONFORMA
Item Code:

Proof number:

0904-619

04

Product Description: ..................................... TIMODINE

Languages: ......................................................
Dimensions (mm): ...................................... 265 x 160

Folded (mm):................................ 23- 2 x 160
Text size (body text):..................................................

Created:........................ INDESIGN CS5

Pharmacode:........................................ 14001

Visual code:..................................................

PG number:...............................300042 000

Date:...............................05 dec 2011

Contact:.................Didier Vandenabeele
Colours used:

Black

Back

PMSxxx PMSxxx PMSxxx PMSxxx

Approved by
Signature

Approval Date

Expand view ⇕

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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