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SEREVENT ACCUHALER

Active substance: SALMETEROL XINAFOATE

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Transcript
Add/Amend to correct the sequence of the diagrams in Section 3.
Very rare (affects less than 1 person in 10,000):
• Breathing difficulties or wheezing that gets
worse straight after taking Serevent. If this
happens stop using your Serevent Accuhaler.
Use your fast-acting ‘reliever’ inhaler to help
your breathing and tell your doctor straight
away.
• Uneven heartbeat or your heart gives an extra
beat (arrhythmias). If this happens do not stop
using Serevent but tell your doctor
• Increases in the amount of sugar (glucose) in
your blood (hyperglycaemia). If you have
diabetes, more frequent blood sugar monitoring
and possibly adjustment of your usual diabetic
treatment may be required
• Sore mouth or throat
• Feeling sick (nausea)
• Aching, swollen joints, or chest pain

Manufacturer and Licence Holder
Previously assessed against UK
This medicine is manufactured by Glaxo Wellcome
PIL dated March 2014. No other
Production, 23 Rue Lavoisier 27000, Evreux,
amendments have been approved.
France and is procured from within the EU and
repackaged by the Product Licence Holder: Lexon
(UK) Limited, Unit 18, Oxleasow Road, East
Moons Moat, Redditch, Worcestershire, B98 0RE.
Outer case
If you have any questions or are not sure about
anything, ask your doctor or pharmacist. They will
have additional information about this medicine
and will be able to advise you.
Mouthpiece
POM PL 15184/1261

5. HOW TO STORE SEREVENT ACCUHALER







Keep out of the sight and reach of children.
Do not store above 30°C.
Store in original package
Store in a dry place
Do not use Serevent after the expiry date which
is stated on the label and carton.

Medicines should not be disposed of via
wastewater or household waste. Ask your
pharmacist how to dispose of medicines no longer
required. These measures will help to protect the
environment.
6. CONTENTS OF THE PACK AND OTHER
INFORMATION
What Serevent Accuhaler contains
• The active substance is 50 micrograms of
salmeterol as xinafoate.



The other ingredient is lactose monohydarte
(which contains milk proteins).

What Serevent Accuhaler looks like and
contents of the pack
• Serevent Accuhaler is a two tone green
moulded plastic device containing a foil strip
with regularly spaced blisters.
• The device has a counter, which tells you the
number of blisters remaining.
• Each dose is pre-dispensed.
• The devices are packed in cartons which hold
one Accuhaler containing 60 inhalations.

®

Serevent Accuhaler

Serevent and Accuhaler are registered trademarks
of the GlaxoSmithKline Group of Companies.

Blind or partially sighted?
Is this leaflet hard to see or read?
Phone Lexon (UK) Limited,
Tel: 01527 505414 for help.

By Aneela Mahmood at 3:15 pm, Jun 17, 2015

Ref: 1261/050615/2/F

®

(salmeterol xinafoate)

Mock up 

Leaflet revision date: 05/06/15
Reporting of side effects
If you get any side effects, talk to your doctor,
pharmacist or nurse. This includes any possible
side effects not listed in this leaflet. You can also
report side effects directly via the Yellow Card
Scheme at www.mhra.gov.uk/yellowcard.
By reporting side effects, you can help provide
more information on the safety of this medicine.

PATIENT INFORMATION LEAFLET

Read all of this leaflet carefully before you
start taking this medicine because it contains
important information for you.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your
doctor or pharmacist.
• This medicine has been prescribed for you only.
Do not pass it on to others. It may harm them,
even if their signs of illness are the same as
yours.
• If you get any side effects, talk to your doctor or
pharmacist. This includes any possible side
effects not listed in this leaflet. See section 4.
Your medicine is called Serevent Accuhaler,
throughout this leaflet it will be referred to as either
Serevent Accuhaler or Serevent.
In this leaflet
1. What Serevent Accuhaler is and what it is used
for
2. What you need to know before you use
Serevent Accuhaler
3. How to use Serevent Accuhaler
4. Possible side effects
5. How to store Serevent Accuhaler
6. Contents of the pack and other information
1. WHAT SEREVENT ACCUHALER IS AND
WHAT IT IS USED FOR
• Serevent Accuhaler contains the medicine
salmeterol. It is a ‘long-acting bronchodilator’. It
helps the airways in the lungs to stay open.
This makes it easier for air to get in and out.
The effects are usually felt within 10 to 20
minutes and last for 12 hours or more.
• The doctor has prescribed it to help prevent
breathing problems. These could be caused by
asthma. Taking Serevent Accuhaler regularly
will help prevent asthma attacks. This also
includes asthma brought on by exercise or at
night.
• Taking Serevent Accuhaler regularly will also
help prevent breathing problems caused by
other chest illnesses such as Chronic
Obstructive Pulmonary Disease (COPD).

Counter
Full Empty

Thumbgrip
Lever





Serevent Accuhaler helps to stop
breathlessness and wheezing coming on. It
does not work once you are breathless or
wheezy. If that happens, you need to use a fast
acting ‘reliever’ medicine, such as salbutamol.
Serevent is supplied to you in an inhaler called
the Accuhaler. You breathe the medicine
directly into your lungs.

If you are being treated for asthma, you should
always be given both a Serevent and a steroid
inhaler to use together.
2. WHAT YOU NEED TO KNOW BEFORE YOU
USE SEREVENT ACCUHALER
Do not take Serevent Accuhaler if:
you are allergic (hypersensitive) to salmeterol
xinafoate, or to the other ingredient lactose.
Take special care with Serevent Accuhaler
• If you are using Serevent for asthma your
doctor will want to regularly check your
symptoms.
• If your asthma or breathing gets worse tell
your doctor straight away. You may find that
you feel more wheezy, your chest feels tight
more often or you may need to use more of
your fast acting ‘reliever’ medicine. If any of
these happen, do not increase your number of
puffs of Serevent. Your chest condition may be
getting worse and you could become seriously
ill. See your doctor as you may need a change
in asthma treatment.
• Once your asthma is well controlled your doctor
may consider it appropriate to gradually reduce
the dose of Serevent.
• If you have been prescribed Serevent for your
asthma, continue to use any other asthma
medication you are already taking. These could
include a steroid inhaler or steroid tablets.
Continue taking the same doses as before,
unless your doctor tells you otherwise. Do this
even if you feel much better. Do not stop
taking your steroid inhaler (or any steroid
tablets) when you start using Serevent.



Your doctor may want to check your health
regularly if you have an overactive thyroid
gland, diabetes mellitus (Serevent may increase
your blood sugar) or heart disease, including an
irregular or fast heartbeat.

Other medicines and Serevent
• Tell your doctor if you are taking or have
recently taken any other medicines. This
includes those for asthma or any other
medicines obtained without a prescription. This
is because Serevent may not be suitable to be
taken with other medicines.
• Inform your doctor before using Serevent if you
are currently being treated for any fungal
infections with medicines containing
ketoconazole or itraconazole, or if you are
being treated for HIV with ritonavir. These
medicines may increase the risk of you
experiencing side effects with Serevent,
including irregular heart beats, or may make
side-effects worse.
• Beta-blockers should be avoided when taking
Serevent, unless your doctor tells you to take
them. Beta-blockers, including atenolol,
propranolol and sotalol, are mostly used for
high blood pressure or other heart conditions.
Tell your doctor if you are taking
beta-blockers or have recently been prescribed
beta-blockers as they may reduce or abolish
the effects of salmeterol.
• Serevent can reduce the amount of potassium
in your blood. If this happens you may notice an
uneven heartbeat, muscle weakness or cramp.
This is more likely to happen if you take
Serevent with some medicines used to treat
high blood pressure (diuretics – water tablets)
and other medicines used to treat breathing
problems such as theophylline or steroids. Your
doctor may ask for you to have blood tests to
check the amount of potassium in your blood. If
you have any concerns discuss them with your
doctor.
Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you
may be pregnant or are planning to have a baby,
ask your doctor or pharmacist for advice before
taking this medicine.
Driving and using machines
The possible side effects associated with Serevent
are unlikely to affect your ability to drive or use
machines.

3. HOW TO USE SEREVENT ACCUHALER
Always use this medicine exactly as your doctor or
pharmacist has told you. Check with your doctor or
pharmacist if you are not sure.
• If you are being treated for asthma, you
should always be given both a Serevent and
a steroid inhaler to use together.
• Use Serevent every day, until your doctor
advises you to stop.
• You will start to feel your medicine working
within the first day of use.
Serevent is for inhalation by mouth only.
Adults and adolescents aged 12 years and
older with Asthma
• The usual starting dose is 1 puff twice a day.
• For people with more severe asthma, your
doctor may increase your dose to 2 puffs twice
a day.
Children with Asthma
• In children aged 4 to 12 the usual dose is 1 puff
twice a day.
• Serevent is not recommended for use in
children below 4 years of age.
Adults with Chronic Obstructive Pulmonary
Disease (COPD) including bronchitis and
emphysema
• The usual starting dose is 1 puff twice a day.
• Not applicable for children and adolescents.
Instructions for use
• Your doctor, nurse or pharmacist should show
you how to use your inhaler. They should check
how you use it from time to time. Not using the
Serevent Accuhaler properly or as prescribed
may mean that it will not help your asthma or
COPD as it should.
• The Serevent Accuhaler device holds blisters
containing Serevent as a powder.
• There is a counter on top of the Serevent
Accuhaler which tells you how many doses are
left. It counts down to 0. The numbers 5 to 0
will appear in red to warn you when there are
only a few doses left. Once the counter shows
0, your inhaler is empty.
Using your inhaler
1. To open your
Serevent Accuhaler,
hold the outer case
in one hand and put
the thumb of your
other hand on the
thumbgrip. Push
your thumb away
from you
as far as it will go. You will hear a click. This will
open a small hole in the mouthpiece.

2. Hold your Serevent
Accuhaler with the
mouthpiece towards
you. You can hold it in
either your right or left
hand. Slide the lever
away from you as far
as it will go. You will
hear a click. This
places a dose of your
medicine in the
mouthpiece.
Every time the lever is pushed back a blister is
opened inside and the powder made ready for you
to inhale. Do not play with the lever as this opens
the blisters and wastes medicine.

If you use more Serevent than you should
It is important to use the inhaler as instructed. If
you accidentally take a larger dose than
recommended, talk to your doctor or pharmacist.
You may notice your heart beating faster than
usual and that you feel shaky and/or dizzy. You
may also have a headache, muscle weakness and
aching joints.
If you forget to use Serevent
Do not take a double dose to make up for the
missed dose. Just take your next dose at the
usual time.
If you have any further questions on the use of
this medicine, ask your doctor or pharmacist.
4. POSSIBLE SIDE EFFECTS

3. Hold the Serevent Accuhaler away from your
mouth, breathe out as far as is comfortable. Do
not breathe into your Serevent Accuhaler.
4. Put the mouthpiece to your lips; breathe in
steadily and deeply through the Serevent
Accuhaler, not through your nose.
Remove the Serevent
Accuhaler from your
mouth.
Hold your breath for
about 10 seconds or
for as long as is
comfortable.

Like all medicines, this medicine can cause side
effects, although not everybody gets them. To
reduce the chances of side effects, your doctor will
prescribe the lowest dose of Serevent to control
your asthma or COPD. These are the side effects
reported by people taking Serevent.
Allergic reactions: you may notice your
breathing suddenly gets worse after using
Serevent. You may be very wheezy and
cough. You may also notice itching and swelling
(usually of the face, lips, tongue or throat). If you
get these effects or they happen suddenly after
using Serevent, tell your doctor straight away.
Allergic reactions to Serevent are very rare (they
affect less than 1 person in 10,000)

Breathe out slowly.
Other side effects are listed below:
5. Afterwards rinse your mouth with water and spit
it out. This may help to stop you getting thrush and
being hoarse.
6. To close the
Serevent Accuhaler,
slide the thumbgrip
back towards you, as
far as it will go. You
will hear a click. The
lever will return to its
original position and is
reset.
Your Serevent Accuhaler is now ready for you to
use again.
Cleaning your inhaler
Wipe the mouthpiece of the Serevent Accuhaler
with a dry tissue to clean it.

Common (affects less than 1 person in 10):
• Muscle cramps
• Feeling shaky; fast or uneven heartbeat
(palpitations), headache, shaking hands
(tremor). Tremors are more likely if you are
taking more than one puff twice daily. These
side effects do not last long and happen less as
treatment with Serevent continues.
Uncommon (affects less than 1 person in 100):
• Rash
• Very fast heart rate (tachycardia). This is more
likely to happen if you are taking more than one
puff twice daily
• Feeling nervous.
Rare (affects less than 1 person in 1,000):
• Feeling dizzy
• Being unable to sleep or finding sleep difficult
• A reduction in the amount of potassium in your
blood (you may get an uneven heartbeat,
muscle weakness, cramp).

Ref: 1261/050615/02/B

Very rare (affects less than 1 person in 10,000):
• Breathing difficulties or wheezing that gets
worse straight after taking Salmeterol. If this
happens stop using your Salmeterol. Use your
fast-acting ‘reliever’ inhaler to help your
breathing and tell your doctor straight away.
• Uneven heartbeat or your heart gives an extra
beat (arrhythmias). If this happens do not stop
using Salmeterol but tell your doctor
• Increases in the amount of sugar (glucose) in
your blood (hyperglycaemia). If you have
diabetes, more frequent blood sugar monitoring
and possibly adjustment of your usual diabetic
treatment may be required
• Sore mouth or throat
• Feeling sick (nausea)
• Aching, swollen joints, or chest pain
Reporting of side effects
If you get any side effects, talk to your doctor,
pharmacist or nurse. This includes any possible
side effects not listed in this leaflet. You can also
report side effects directly via the Yellow Card
Scheme at www.mhra.gov.uk/yellowcard.
By reporting side effects, you can help provide
more information on the safety of this medicine.
5. HOW TO STORE SALMETEROL







Keep out of the sight and reach of children.
Do not store above 30°C.
Store in original package
Store in a dry place
Do not use Salmeterol after the expiry date
which is stated on the label and carton.

Medicines should not be disposed of via
wastewater or household waste. Ask your
pharmacist how to dispose of medicines no longer
required. These measures will help to protect the
environment.
6. CONTENTS OF THE PACK AND OTHER
INFORMATION
What Salmeterol contains
• The active substance is 50 micrograms of
salmeterol as xinafoate.



The other ingredient is lactose monohydarte
(which contains milk proteins).

What Salmeterol looks like and contents of the
pack
• Salmeterol is a two tone green
moulded plastic device containing a foil strip
with regularly spaced blisters.
• The device has a counter, which tells you the
number of blisters remaining.
• Each dose is pre-dispensed.
• The devices are packed in cartons which hold
one Accuhaler containing 60 inhalations.

Manufacturer and Licence Holder
This medicine is manufactured by Glaxo Wellcome
Production, 23 Rue Lavoisier 27000, Evreux,
France and is procured from within the EU and
repackaged by the Product Licence Holder: Lexon
(UK) Limited, Unit 18, Oxleasow Road, East
Moons Moat, Redditch, Worcestershire, B98 0RE.

PATIENT INFORMATION LEAFLET

Salmeterol 50 micrograms Accuhaler ®
(salmeterol xinafoate)
Counter
Full Empty

Outer case
If you have any questions or are not sure about
anything, ask your doctor or pharmacist. They will
have additional information about this medicine
and will be able to advise you.

Thumbgrip
Mouthpiece

POM

Ref: 1261/050615/2/F

Lever

PL 15184/1261

Leaflet revision date: 05/06/15

Blind or partially sighted?
Is this leaflet hard to see or read?
Phone Lexon (UK) Limited,
Tel: 01527 505414 for help.

Read all of this leaflet carefully before you
start taking this medicine because it contains
important information for you.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your
doctor or pharmacist.
• This medicine has been prescribed for you only.
Do not pass it on to others. It may harm them,
even if their signs of illness are the same as
yours.
• If you get any side effects, talk to your doctor or
pharmacist. This includes any possible side
effects not listed in this leaflet. See section 4.
Your medicine is called Salmeterol,
throughout this leaflet it will be referred to as
Salmeterol.
In this leaflet
1. What Salmeterol is and what it is used
for
2. What you need to know before you use
Salmeterol
3. How to use Salmeterol
4. Possible side effects
5. How to store Salmeterol
6. Contents of the pack and other information
1. WHAT SALMETEROL IS AND
WHAT IT IS USED FOR
• Salmeterol contains the medicine
salmeterol. It is a ‘long-acting bronchodilator’. It
helps the airways in the lungs to stay open.
This makes it easier for air to get in and out.
The effects are usually felt within 10 to 20
minutes and last for 12 hours or more.
• The doctor has prescribed it to help prevent
breathing problems. These could be caused by
asthma. Taking Salmeterol regularly
will help prevent asthma attacks. This also
includes asthma brought on by exercise or at
night.
• Taking Salmeterol regularly will also
help prevent breathing problems caused by
other chest illnesses such as Chronic
Obstructive Pulmonary Disease (COPD).





Salmeterol helps to stop breathlessness and
wheezing coming on. It does not work once you
are breathless or wheezy. If that happens, you
need to use a fast acting ‘reliever’ medicine,
such as salbutamol.
Salmeterol is supplied to you in an inhaler
called the Accuhaler. You breathe the medicine
directly into your lungs.

If you are being treated for asthma, you should
always be given both a Salmeterol and a
steroid inhaler to use together.
2. WHAT YOU NEED TO KNOW BEFORE YOU
USE SALMETEROL
Do not take Salmeterol if:
you are allergic (hypersensitive) to salmeterol
xinafoate, or to the other ingredient lactose.
Take special care with Salmeterol
• If you are using Salmeterol for asthma your
doctor will want to regularly check your
symptoms.
• If your asthma or breathing gets worse tell
your doctor straight away. You may find that
you feel more wheezy, your chest feels tight
more often or you may need to use more of
your fast acting ‘reliever’ medicine. If any of
these happen, do not increase your number of
puffs of Salmeterol. Your chest condition may
be getting worse and you could become
seriously ill. See your doctor as you may need
a change in asthma treatment.
• Once your asthma is well controlled your doctor
may consider it appropriate to gradually reduce
the dose of Salmeterol.
• If you have been prescribed Salmeterol for your
asthma, continue to use any other asthma
medication you are already taking. These could
include a steroid inhaler or steroid tablets.
Continue taking the same doses as before,
unless your doctor tells you otherwise. Do this
even if you feel much better. Do not stop
taking your steroid inhaler (or any steroid
tablets) when you start using Salmeterol.



Your doctor may want to check your health
regularly if you have an overactive thyroid
gland, diabetes mellitus (Salmeterol may
increase your blood sugar) or heart disease,
including an irregular or fast heartbeat.

Other medicines and Salmeterol
• Tell your doctor if you are taking or have
recently taken any other medicines. This
includes those for asthma or any other
medicines obtained without a prescription. This
is because Salmeterol may not be suitable to
be taken with other medicines.
• Inform your doctor before using Salmeterol if
you are currently being treated for any fungal
infections with medicines containing
ketoconazole or itraconazole, or if you are
being treated for HIV with ritonavir. These
medicines may increase the risk of you
experiencing side effects with Salmeterol,
including irregular heart beats, or may make
side-effects worse.
• Beta-blockers should be avoided when taking
Salmeterol, unless your doctor tells you to take
them. Beta-blockers, including atenolol,
propranolol and sotalol, are mostly used for
high blood pressure or other heart conditions.
Tell your doctor if you are taking beta-blockers
or have recently been prescribed beta-blockers
as they may reduce or abolish the effects of
salmeterol.
• Salmeterol can reduce the amount of potassium
in your blood. If this happens you may notice an
uneven heartbeat, muscle weakness or cramp.
This is more likely to happen if you take
Salmeterol with some medicines used to treat
high blood pressure (diuretics – water tablets)
and other medicines used to treat breathing
problems such as theophylline or steroids. Your
doctor may ask for you to have blood tests to
check the amount of potassium in your blood. If
you have any concerns discuss them with your
doctor.
Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you
may be pregnant or are planning to have a baby,
ask your doctor or pharmacist for advice before
taking this medicine.

3. HOW TO USE SALMETEROL
Always use this medicine exactly as your doctor or
pharmacist for advice before taking this medicine.
• If you are being treated for asthma, you
should always be given both a Salmeterol
and a steroid inhaler to use together.
• Use Salmeterol every day, until your doctor
advises you to stop.
• You will start to feel your medicine working
within the first day of use.
Salmeterol is for inhalation by mouth only.
Adults and adolescents aged 12 years and
older with Asthma
• The usual starting dose is 1 puff twice a day.
• For people with more severe asthma, your
doctor may increase your dose to 2 puffs twice
a day.
Children with Asthma
• In children aged 4 to 12 the usual dose is 1 puff
twice a day.
• Salmeterol is not recommended for use in
children below 4 years of age.
Adults with Chronic Obstructive Pulmonary
Disease (COPD) including bronchitis and
emphysema
• The usual starting dose is 1 puff twice a day.
• Not applicable for children and adolescents.
Instructions for use
• Your doctor, nurse or pharmacist should show
you how to use your inhaler. They should check
how you use it from time to time. Not using the
Salmeterol properly or as prescribed
may mean that it will not help your asthma or
COPD as it should.
• The Salmeterol device holds blisters
containing Salmeterol as a powder.
• There is a counter on top of the Salmeterol
which tells you how many doses are
left. It counts down to 0. The numbers 5 to 0
will appear in red to warn you when there are
only a few doses left. Once the counter shows
0, your inhaler is empty.
Using your inhaler

Driving and using machines
The possible side effects associated with
Salmeterol are unlikely to affect your ability to
drive or use machines.

2. Hold your
Salmeterol with the
mouthpiece towards
you. You can hold it in
either your right or left
hand. Slide the lever
away from you as far
as it will go. You will
hear a click. This
places a dose of your
medicine in the
mouthpiece.

1. To open your
Salmeterol, hold the
outer case
in one hand and put
the thumb of your
other hand on the
thumbgrip. Push
your thumb away
from you
as far as it will go. You will hear a click. This will
open a small hole in the mouthpiece.

Every time the lever is pushed back a blister is
opened inside and the powder made ready for you
to inhale. Do not play with the lever as this opens
the blisters and wastes medicine.

If you use more Salmeterol than you should
It is important to use the inhaler as instructed. If
you accidentally take a larger dose than
recommended, talk to your doctor or pharmacist.
You may notice your heart beating faster than
usual and that you feel shaky and/or dizzy. You
may also have a headache, muscle weakness and
aching joints.
If you forget to use Salmeterol
Do not take a double dose to make up for a
missed dose. Just take your next dose at the
usual time.
If you have any further questions on the use of
this medicine, ask your doctor or pharmacist.
4. POSSIBLE SIDE EFFECTS

3. Hold the Salmeterol away from your mouth,
breathe out as far as is comfortable. Do not
breathe into your Salmeterol.
4. Put the mouthpiece to your lips; breathe in
steadily and deeply through the Salmeterol, not
through your nose.
Remove the
Salmeterol from your
mouth.
Hold your breath for
about 10 seconds or
for as long as is
comfortable.

Like all medicines, this medicine can cause side
effects, although not everybody gets them. To
reduce the chances of side effects, your doctor will
prescribe the lowest dose of Salmeterol to control
your asthma or COPD. These are the side effects
reported by people taking Salmeterol.
Allergic reactions: you may notice your
breathing suddenly gets worse after using
Salmeterol. You may be very wheezy and
cough. You may also notice itching and swelling
(usually of the face, lips, tongue or throat). If you
get these effects or they happen suddenly after
using Salmeterol, tell your doctor straight away.
Allergic reactions to Salmeterol are very rare (they
affect less than 1 person in 10,000)

Breathe out slowly.
Other side effects are listed below:
5. Afterwards rinse your mouth with water and spit
it out. This may help to stop you getting thrush and
being hoarse.
6. To close the
Salmeterol, slide the
thumbgrip back
towards you, as
far as it will go. You
will hear a click. The
lever will return to its
original position and
is reset.
Your Salmeterol is now ready for you to use again.
Cleaning your inhaler
Wipe the mouthpiece of the Salmeterol with a dry
tissue to clean it.

Common (affects less than 1 person in 10):
• Muscle cramps
• Feeling shaky; fast or uneven heartbeat
(palpitations), headache, shaking hands
(tremor). Tremors are more likely if you are
taking more than one puff twice daily. These
side effects do not last long and happen less as
treatment with Salmeterol continues.
Uncommon (affects less than 1 person in 100):
• Rash
• Very fast heart rate (tachycardia). This is more
likely to happen if you are taking more than one
puff twice daily
• Feeling nervous.
Rare (affects less than 1 person in 1,000):
• Feeling dizzy
• Being unable to sleep or finding sleep difficult
• A reduction in the amount of potassium in your
blood (you may get an uneven heartbeat,
muscle weakness, cramp).

Ref: 1261/050615/02/B

Expand view ⇕

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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