RYTHMODAN 150MG CAPSULES

Active substance: DISOPYRAMIDE

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Tell your doctor or pharmacist if any of
the following side effects gets serious or
lasts longer than a few days. Also tell
them if you notice any side effects not
listed in this leaflet:
• Feeling sick (nausea) or being sick
(vomiting), dry mouth, indigestion,
diarrhoea, constipation, stomach pain, loss
of appetite
• Difficulty in passing urine, especially in
men with prostate problems
• Difficulty in getting or maintaining an
erection, or in ejaculating (impotence)
• Mood changes or mental problems
• Blurred or double vision
• Yellowing of your skin or eyes (jaundice)
• Worsening of myasthenia gravis (a disease
which causes muscle weakness)
• You may get more infections than usual.
This could be caused by a lowering in
the number of white blood cells (called
neutropenia)
• Low blood sugar levels (hypoglycaemia).
Signs include sweating, paleness,
headache, faintness or drowsiness
• Problems with memory or attention span,
difficulty thinking clearly

5.How to store Rythmodan Capsules

6.Further information

Keep out of the reach and sight of
children.
Store below 25°C.
Do not use Rythmodan Capsules after the
expiry date which is stated on the carton
after EXP. The expiry date refers to the last
day of that month.

What Rythmodan Capsules contain

Do not use Rythmodan Capsules if you
notice your capsules are crumbling, broken
or discoloured.

What Rythmodan Capsules look like and
contents of the pack

Medicines should not be disposed of via
wastewater or household waste. Ask your
pharmacist how to dispose of medicines no
longer required. These measures will help to
protect the environment.

- Each capsule contains 150mg of the active
substance, disopyramide
- The other ingredients are maize starch,
magnesium stearate, STA-RX 1500
(pregelatinised starch), talc, gelatine,
indigo carmine, iron oxide and titanium
dioxide

The capsules have a white cap and body
and are printed with ‘RY’ on one part and
‘150’ on the other, in black ink.
The tablets are available in blister-packs of
84 capsules.

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If you are taking any of the following
medicines that can increase the risk
of unusual heartbeats (arrhythmias)
when taken at the same time as
Rythmodan Capsules:
• Medicines for depression such as
amitriptyline, imipramine or
maprotiline
• Medicines for male sexual problems
such as sildenafil, tadalafil or
vardenafil
• Antibiotics such as erythromycin,
clarithromycin, azithromycin or
sparfloxacin
• Antihistamines such as astemizole or
terfenadine
• Cisapride - used for heartburn
• Pentamidine - used for pneumonia
• Pimozide and thioridazine - used for
schizophrenia
The following medicines may affect the
way Rythmodan Capsules works:
• Amphotericin B - used for fungal
infections
• Tetracosactide - used to test some
hormone problems
• Rifampicin - used for infections
• Atropine – used in eye drops and in
cough and cold medicines

PACKAGE LEAFLET:
INFORMATION FOR THE USER

Rythmodan® 150mg Capsules
disopyramide

Is this leaflet hard to
see or read?
Phone 01483 505515 for
help
Read all of this leaflet carefully before
you start taking this medicine.
• Keep this leaflet. You may need to read
it again.
• If you have any further questions, ask
your doctor or pharmacist.
• This medicine has been prescribed for
you. Do not pass it on to others. It may
harm them, even if their symptoms are
the same as yours.

• Anticholinergic medicines - includes some
medicines used for irritable bowel
syndrome, asthma or incontinence
• Medicines used to calm emotional or
mental problems or stop you feeling sick
or being sick such as chlorpromazine or
prochlorperazine
• Water tablets (diuretics) such as
furosemide
• Corticosteroids such as hydrocortisone,
betamethasone or prednisolone
• Laxatives such as bisacodyl or senna
• Medicines for epilepsy such as
phenobarbital, primidone or phenytoin
Rythmodan Capsules may affect the way
the following medicines work:
• Medicines for HIV infections such as
ritonavir, indinavir or saquinavir
• Theophylline - used for wheezing or
difficulty in breathing
• Ciclosporin - used to help prevent
rejection of transplants
• Warfarin - used to thin the blood

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In this leaflet:
1. What Rythmodan Capsules are and what
they are used for
2. Before you take Rythmodan Capsules
3. How to take Rythmodan Capsules
4. Possible side effects
5. How to store Rythmodan Capsules
6. Further information

i

The name of your medicine is Rythmodan
150mg Capsules (called Rythmodan Capsules
in this leaflet). Rythmodan Capsules contain
a medicine called disopyramide. This
belongs to a group of medicines called
anti-arrhythmic agents.
It works by controlling the uneven beating
of your heart and returns it to the normal
rhythm.
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Talk to your doctor before taking this
medicine if you are pregnant, might
become pregnant, or think you may be
pregnant.
If you are breast-feeding or planning to
breast-feed, talk to your doctor or
pharmacist before taking any medicine. This
is because small amounts of this medicine
may pass into the mothers’ milk.

Driving and using machines
Rythmodan Capsules may affect your ability
to concentrate and react quickly. You may
have blurred vision or become dizzy or
light-headed. If this happens, do not drive
or use any tools or machines.

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• If any of the side effects gets serious, or
if you notice any side effects not listed
in this leaflet, please tell your doctor or
pharmacist.

1.What Rythmodan Capsules are
and what they are used for

Pregnancy and breast-feeding

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It is used for controlling your heartbeat in
the following situations:
• Arrhythmias - where your heartbeats are
uneven, or unusually fast or slow
• To keep your heart beating at a normal
rhythm
• To stop unusual heartbeats (arrhythmias)
happening after a heart attack
• To stop unusual heartbeats (arrhythmias)
during an operation

2.Before you take Rythmodan Capsules
Take special care with Rythmodan
Capsules
Do not take Rythmodan Capsules
and tell your doctor if:
You are allergic (hypersensitive) to
disopyramide or any of the other
ingredients of Rythmodan Capsules (see
Section 6: Further Information)
Signs of an allergic reaction include: a
rash, swallowing or breathing problems,
swelling of your lips, face, throat or
tongue.
You have any other heart problems apart from unusual heartbeats
(arrhythmias)
You are taking other medicines to
control your heart rhythm (see section
below ‘Taking other medicines’)
You are taking other medicines which
could cause unusual heartbeats (see
section below ‘Taking other medicines’)
Do not take this medicine if any of the
above apply to you. If you are not sure,
talk to your doctor or pharmacist before
taking Rythmodan Capsules.

Check with your doctor or pharmacist
before taking your medicine if:
L You have low levels of potassium in
your blood (called hypokalaemia)
L You have low blood sugar levels. This
can happen if you have diabetes, a low
body weight, a poor diet or if you are
elderly
L You have glaucoma (raised pressure in
the eye which causes painful eyes with
blurred vision)
L You have an enlarged prostate
L You have kidney and liver problems
L You have a disease which causes muscle
weakness (myasthenia gravis)
L You are elderly and have problems with
your memory or attention span, or
sometimes have difficulty thinking clearly
If you are not sure if any of the above
applies to you, talk to your doctor or
pharmacist before taking Rythmodan
Capsules.

Taking other medicines
Please tell your doctor or pharmacist if you
are taking or have recently taken any other
medicines. This includes medicines you buy
without a prescription, including herbal
medicines. This is because Rythmodan
Capsules can affect the way some other
medicines work.
Also some medicines can affect the way
Rythmodan Capsules works.
In particular, do not take this medicine,
and tell your doctor:
If you are taking any of the following
medicines for uneven heartbeats
(arrhythmias):
• Beta-blockers such as propranolol,
oxprenolol or acebutolol
• Verapamil – also used for chest pain
or high blood pressure
• Digoxin – also used for heart
problems

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3.How to take Rythmodan Capsules
Always take Rythmodan Capsules exactly as
your doctor has told you. You should check
with your doctor or pharmacist if you are
not sure.

Taking this medicine
• Take this medicine by mouth
• Swallow the capsules with a drink of
water
• If you feel the effect of your medicine is
too weak or too strong, do not change
the dose yourself, but ask your doctor

Adults
The usual dose is two to five capsules
(300mg to 800mg) daily in divided doses.

Elderly
Your doctor may lower your dose if you
have any kidney or liver problems.

Children
Rythmodan Capsules are not suitable for
use in children.

If you take more Rythmodan Capsules
than you should
If you take more capsules than you should,
talk to a doctor or go to a hospital
casualty department straight away. Take the
medicine pack with you. This is so the
doctor knows what you have taken. The
following effects may happen: dizziness,
feeling tired, uneven heartbeat (palpitations),
dry mouth, difficulty in passing water
(urinating), feeling or being sick, stomach
pain or fits (seizures).

If you forget to take Rythmodan Capsules
Do not take a double dose to make up for
a forgotten capsule.

If you stop taking Rythmodan Capsules
Keep taking Rythmodan Capsules until your
doctor tells you to stop.

?

If you have any further questions
about this medicine, ask your doctor
or pharmacist.

Blood tests
Your doctor may ask you to have regular
blood tests to check your blood sugar
levels.

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Marketing Authorisation Holder and
Manufacturer
Marketing Authorisation Holder
Sanofi-aventis, One Onslow Street, Guildford,
Surrey, GU1 4YS, UK
Tel: 01483 505515
Fax: 01483 535432
email: uk-medicalinformation@sanofiaventis.com
Manufacturer
Sanofi Winthrop Industrie
56, route de Choisy-au-Bac
60205 Compiegne
France
This leaflet does not contain all the
information about your medicine. If you
have any questions or are not sure about
anything, ask your doctor or pharmacist.

This leaflet was last revised in February
2010.

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4.Possible side effects
Like all medicines, Rythmodan Capsules can
cause side effects, although not everybody
gets them.

Tell your doctor straight away if you
notice any of the following serious side
effects - you may need urgent medical
treatment
• If you have an allergic reaction. The signs
may include: a skin rash, swallowing or
breathing problems, swelling of your lips,
face, throat or tongue

Tell your doctor as soon as possible if
you have any of the following:
• Feeling faint, dizzy or light-headed
• Palpitations or an uneven, fast or slow
heartbeat that you have not had before
or that gets worse

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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