RISPERIDONE 2MG TABLETS

Active substance: RISPERIDONE

View full screen / Print PDF » Download PDF ⇩

Transcript
PACKAGE LEAFLET: INFORMATION FOR THE USER

RISPERDAL® 1mg TABLETS
®
RISPERDAL 2mg TABLETS
(risperidone)
Read all of this leaflet carefully before you
start taking this medicine because it contains
important information for you.
• Keep this leaflet. You may need to read it
again.
• If you have any further questions, ask your
doctor or pharmacist.
• This medicine has been prescribed for you
only. Do not pass it on to others. It may harm
them, even if their signs of illness are the same
as yours.
• If you get any side effects, talk to your doctor
or pharmacist. This includes any possible side
effects not listed in this leaflet. See section 4.
The name of your medicine is Risperdal 1mg
Tablets and Risperdal 2mg Tablets but it will be
referred as Risperdal throughout this leaflet.

Please note that this leaflet also contains
information about other strengths such as
Risperdal 0.5mg, 3mg, 4mg and 6mg Tablets and
Risperdal Quicklet 0.5 mg, 1mg, 2mg, 3mg and
4mg Orodispersible tablets.
What is in this leaflet:
1

What Risperdal is and what it is used for

2

What you need to know before you take
Risperdal
How to take Risperdal

3
4

Possible side effects

5

How to store Risperdal

6

Contents of the pack and other information

1 What Risperdal is and what it is used for
Risperdal belongs to a group of medicines called
‘anti-psychotics’.
Risperdal is used to treat the following:
• Schizophrenia, where you may see, hear or
feel things that are not there, believe things
that are not true or feel unusually suspicious,
or confused
• Mania, where you may feel very excited,
elated, agitated, enthusiastic or hyperactive
Mania occurs in an illness called “bipolar
disorder”

• Short-term treatment (up to 6 weeks) of longterm aggression in people with Alzheimer’s
dementia, who harm themselves or others.
Alternative (non-drug) treatments should have
been used previously.
• Short-term treatment (up to 6 weeks) of longterm, aggression in intellectually disabled
children (at least 5 years of age) and
adolescents with conduct disorder.
Risperdal can help alleviate the symptoms of
your disease and stop your symptoms from
coming back.

2 What you need to know before you take Risperdal
Do not take Risperdal if:
• You are allergic (hypersensitive) to risperidone
or any of the other ingredients of this medicine
(listed in section 6).
If you are not sure if the above applies to you,
talk to your doctor or pharmacist before using
Risperdal.
Warnings and precautions
Talk to your doctor or pharmacist before
taking Risperdal if:
• You have a heart problem. Examples include
an irregular heart rhythm or if you are prone to
low blood pressure or if you are using
medicines for your blood pressure. Risperdal
may cause low blood pressure. Your dose may
need to be adjusted
• You know of any factors which would favour
you having a stroke, such as high blood
pressure, cardiovascular disorder or blood
vessel problems in the brain
• You have ever experienced involuntary
movements of the tongue, mouth and face
• You have ever had a condition whose
symptoms include high temperature, muscle
stiffness, sweating or a lowered level of
consciousness (also known as Neuroleptic
Malignant Syndrome)
• You have Parkinson’s disease or dementia
• You know that you have had low levels of white
blood cells in the past (which may or may not
have been caused by other medicines)
• You are diabetic
• You have epilepsy
• You are a man and you have ever had a
prolonged or painful erection
• You have problems controlling your body
temperature or overheating
• You have kidney problems
• You have liver problems
• You have an abnormally high level of the
hormone prolactin in your blood or if you have
a possible prolactin-dependent tumour.
• You or someone else in your family has a
history of blood clots, as antipsychotics have
been associated with formation of blood clots.
If you are not sure if any of the above applies to
you, talk to your doctor or pharmacist before
using Risperdal.
As dangerously low numbers of a certain type of
white blood cell needed to fight infection in your
blood has been seen very rarely with patients
taking Risperdal, your doctor may check your
white blood cell counts.
Risperdal may cause you to gain weight.
Significant weight gain may adversely affect your
health. Your doctor should regularly measure
your body weight.
As diabetes mellitus or worsening of pre-existing
diabetes mellitus have been seen with patients
taking Risperdal, your doctor should check for
signs of high blood sugar. In patients with preexisting diabetes mellitus blood glucose should
be monitored regularly.
During an operation on the eye for cloudiness of
the lens (cataract), the pupil (the black circle in
the middle of your eye) may not increase in size
as needed. Also, the iris (the coloured part of the
eye) may become floppy during surgery and that
may lead to eye damage. If you are planning to
have an operation on your eye, make sure you
tell your eye doctor that you are taking this
medicine
Elderly people with dementia
In elderly patients with dementia, there is an
increased risk of stroke. You should not take
risperidone if you have dementia caused by
stroke.
During treatment with risperidone you should
frequently see your doctor.
Medical treatment should be sought straight
away if you or your care-giver notice a sudden

change in your mental state or sudden weakness
or numbness of your face, arms or legs,
especially on one side, or slurred speech, even
for a short period of time. These may be signs of
a stroke.
Children and adolescents
Before treatment is started for conduct disorder,
other causes of aggressive behaviour should
have been ruled out.
If during treatment with risperidone tiredness
occurs, a change in the time of administration
might improve attention difficulties.
Before treatment is started your, or your child’s
body weight may be measured and it may be
regularly monitored during treatment.
Other medicines and Risperdal
Tell your doctor or pharmacist if you are taking,
have recently taken or might take any other
medicines.
It is especially important to talk to your
doctor or pharmacist if you are taking any of
the following:
• Medicines that work on your brain such as to
help you calm down (benzodiazepines) or
some medicines for pain (opiates), medicines
for allergy (some antihistamines), as
risperidone may increase the sedative effect of
all of these
• Medicines that may change the electrical
activity of your heart, such as medicines for
malaria, heart rhythm problems, allergies (antihistamines), some antidepressants or other
medicines for mental problems
• Medicines that cause a slow heart beat
• Medicines that cause low blood potassium
(such as certain diuretics)
• Medicines to treat raised blood pressure.
Risperdal can lower blood pressure
• Medicines for Parkinson's disease (such as
levodopa)
• Water tablets (diuretics) used for heart
problems or swelling of parts of your body due
to a build up of too much fluid (such as
furosemide or chlorothiazide). Risperdal taken
by itself or with furosemide, may have an
increased risk of stroke or death in elderly
people with dementia.
The following medicines may reduce the
effect of risperidone
• Rifampicin (a medicine for treating some
infections)
• Carbamazepine, phenytoin (medicines for
epilepsy)
• Phenobarbital
If you start or stop taking such medicines you
may need a different dose of risperidone.
The following medicines may increase the
effect of risperidone
• Quinidine (used for certain types of heart
disease)
• Antidepressants such as paroxetine, fluoxetine,
tricyclic antidepressants
• Medicines known as beta blockers (used to
treat high blood pressure)
• Phenothiazines (such as medicines used to
treat psychosis or to calm down)
• Cimetidine, ranitidine (blockers of the acidity of
stomach)
If you start or stop taking such medicines you
may need a different dose of risperidone.
If you are not sure if any of the above applies to
you, talk to your doctor or pharmacist before
using Risperdal.
Risperdal with food, drink and alcohol
You can take this medicine with or without food.
You should avoid drinking alcohol when taking
Risperdal.

Pregnancy, breast-feeding and fertility
• If you are pregnant or breast-feeding, think you
may be pregnant or are planning to have a baby,
ask your doctor or pharmacist for advice before
taking this medicine. Your doctor will decide if
you can take it
• The following symptoms may occur in newborn
babies, of mothers that have used Risperdal in
the last trimester (last three months of their
pregnancy): shaking, muscle stiffness and/or
weakness, sleepiness, agitation, breathing
problems, and difficulty in feeding. If your baby
develops any of these symptoms you may need
to contact your doctor.
• Risperdal can raise your levels of a hormone
called “prolactin” that may impact fertility (see
Possible side effects).

Driving and using machines
Dizziness, tiredness, and vision problems may
occur during treatment with Risperdal. Do not drive
or use any tools or machines without talking to your
doctor first.
Risperdal contains lactose or aspartame
The film-coated tablets contain lactose, a type of
sugar. If you have been told by your doctor that you
have an intolerance to some sugars, contact your
doctor before taking this medicinal product.
The 2mg and 6mg film-coated tablets contain
sunset yellow (E110) that may cause allergic
reactions.
The orodispersible tablets contain aspartame, a
source of phenylalanine which may be harmful for
people with phenylketonuria.

3 How to take Risperdal
Always take this medicine exactly as your doctor
has told you. Check with your doctor or
pharmacist if you are not sure.
The recommended dose is as follows:
For the treatment of schizophrenia
Adults
• The usual starting dose is 2mg per day, this
may be increased to 4mg per day on the
second day
• Your dose may then be adjusted by your
doctor depending on how you respond to the
treatment
• Most people feel better with daily doses of 4 to
6mg.
• This total daily dose can be divided into either
one or two doses a day. Your doctor will tell
you which is the best for you.
Elderly people
• Your starting dose will normally be 0.5mg twice
a day
• Your dose may then be gradually increased by
your doctor to 1mg to 2mg twice a day
• Your doctor will tell you which is the best for
you.
For the treatment of mania
Adults
• Your starting dose will usually be 2mg once a
day
• Your dose may then be gradually adjusted by
your doctor depending on how you respond to
the treatment
• Most people feel better with doses of 1 to 6mg
once a day.
Elderly people
• Your starting dose will usually be 0.5mg twice
a day
• Your dose may then be gradually adjusted by
your doctor to 1mg to 2mg twice a day
depending on how much you respond to the
treatment.
For the treatment of long-standing
aggression in people with Alzheimer’s
dementia
Adults (including elderly people)
• Your starting dose will normally be 0.25mg
twice a day
• Your dose may then be gradually adjusted by
your doctor depending on how you respond to
the treatment
• Most people feel better with 0.5mg twice a day.
Some patients may need 1mg twice a day
• Treatment duration in patients with Alzheimer’s
dementia should be not more than 6 weeks.
Use in children and adolescents
• Children and adolescents under 18 years old
should not be treated with Risperdal for
schizophrenia or mania.
For the treatment of conduct disorder
The dose will depend on your child’s weight:
For children who weigh less than 50kg
• The starting dose will normally be 0.25mg once
a day
• The dose may be increased every other day in
steps of 0.25mg per day.
• The usual maintenance dose is 0.25mg to
0.75mg once a day.

For children who weigh 50kg or more
• The starting dose will normally be 0.5mg once
a day
• The dose may be increased every other day in
steps of 0.5mg per day.
• The usual maintenance dose is 0.5mg to 1.5mg
once a day.
Treatment duration in patients with conduct
disorder should be not more than 6 weeks.
Children under 5 years old should not be treated
with Risperdal for conduct disorder.
People with kidney or liver problems
Regardless of the disease to be treated, all
starting doses and following doses of risperidone
should be halved. Dose increases should be
slower in these patients.
Risperidone should be used with caution in this
patient group.
Risperdal film-coated tablets
• You should swallow your tablet with a drink of
water
• The score line is only there to help you break
the tablet if you have difficulty swallowing it
whole.
Risperdal Quicklet orodispersible tablets
Only remove a tablet from the blister when it is
time to take your medicine.
• Peel open a blister to expose the tablet
• Do not push the tablet through the foil because
it may break
• Remove the tablet from the blister with dry
hands
• Place the tablet on your tongue straight away
• The tablet will begin disintegrating within
seconds
• It can then be swallowed with or without water.
If you take more Risperdal than you should
• See a doctor right away. Take the medicine
pack with you
• In case of overdose you may feel sleepy or
tired, or have abnormal body movements,
problems standing and walking, feel dizzy due
to low blood pressure, or have abnormal heart
beats or fits.
If you forget to take Risperdal
• If you forget to take a dose, take it as soon as
you remember it. However, if it is almost time
for your next dose, skip the missed dose and
continue as usual. If you miss two or more
doses, contact your doctor
• Do not take a double dose (two doses at the
same time) to make up for a forgotten dose
If you stop taking Risperdal
You should not stop taking this medicine unless
told to do so by your doctor. Your symptoms may
return. If your doctor decides to stop this
medicine, your dose may be decreased gradually
over a few days.
If you have any further questions on the use of
this medicine, ask your doctor or pharmacist.

4 Possible side effects
Like all medicines, this medicine can cause side
effects, although not everybody gets them.
Tell your doctor immediately if you:
• Experience blood clots in the veins, especially
in the legs (symptoms include swelling, pain,
and redness in the leg), which may travel
through blood vessels to the lungs causing
chest pain and difficulty breathing. If you notice
any if these symptoms seek medical advice
immediately
• Have dementia and experience a sudden
change in your mental state or sudden
weakness or numbness of your face, arms or
legs, especially on one side, or slurred speech,
even for a short period of time. These may be
signs of a stroke
• Experience fever, muscle stiffness, sweating or
a lowered level of consciousness (a disorder
called “Neuroleptic Malignant Syndrome”).
Immediate medical treatment may be needed

• Are a man and experience prolonged or painful
erection. This is called priapism. Immediate
medical treatment may be needed
• Experience involuntary rhythmic movements of
the tongue, mouth and face. Withdrawal of
risperidone may be needed
• Experience severe allergic reaction
characterised by fever, swollen mouth, face, lip
or tongue, shortness of breath, itching, skin
rash or drop in blood pressure.

4 Possible side effects (continued)
The following side effects may happen:
Very Common (affects more than 1 user in
10):
• Difficulty falling or staying asleep
• Parkinsonism: This condition may include:
slow or impaired movement, sensation of
stiffness or tightness of the muscles (making
your movements jerky), and sometimes even a
sensation of movement “freezing up” and then
restarting. Other signs of parkinsonism include
a slow shuffling walk, a tremor while at rest,
increased saliva and/or drooling, and a loss of
expression on the face.
• Feeling sleepy, or less alert
• Headache
Common (affects 1 to 10 users in 100):
• Pneumonia, Infection of the chest (bronchitis),
Common cold symptoms, Sinus infection
Urinary tract infection Ear infection, Feeling like
you have the flu
• Risperdal can raise your levels of a hormone
called “prolactin” found on a blood test (which
may or may not cause symptoms). When
symptoms of high prolactin occur, they may
include in men breast swelling, difficulty in
getting or maintaining erections, or other
sexual dysfunction. In women they may include
breast discomfort, leakage of milk from the
breasts, missed menstrual periods, or other
problems with your cycle.
• Weight gain, Increased appetite, Decreased
appetite
• Sleep disorder, Irritability, Depression, Anxiety,
Restlessness
• Dystonia: This is a condition involving slow or
sustained involuntary contraction of muscles.
While it can involve any part of the body (and
may result in abnormal posture), dystonia often
involves muscles of the face, including
abnormal movements of the eyes, mouth,
tongue or jaw.
• Dizziness
• Dyskinesia: This is a condition involving
involuntary muscle movements, and can
include repetitive, spastic or writhing
movements, or twitching.
• Tremor (shaking)
• Blurry vision, Eye infection or “pink eye”
• Rapid heart rate, High blood pressure,
Shortness of breath
• Sore throat, Cough, Nosebleeds, Stuffy nose
• Abdominal pain, Abdominal discomfort,
Vomiting, Nausea, Constipation, Diarrhoea,
Indigestion, Dry mouth, Toothache
• Rash, Skin redness
• Muscle spasms, Bone or muscle ache, Back
pain, Joint pain
• Incontinence (lack of control) of urine
• Swelling of the body, arms or legs, Fever,
Chest pain, Weakness, Fatigue (tiredness),
Pain
• Fall.
Uncommon (affects 1 to 10 users in 1000):
• Infection of the breathing passages, Bladder
infection, ‘Eye infection, Tonsillitis, Fungal
infection of the nails, Infection of the skin, An
infection confined to a single area of skin or
part of the body, Viral infection, Skin
inflammation caused by mites
• Decrease in the type of white blood cells that
help to protect you against infection, White
blood cell count decreased Decrease in
platelets (blood cells that help you stop
bleeding), Anemia, Decrease in red blood cells,
Increase in eosinophils (a type of white blood
cell) in your blood
• Allergic reaction
• Diabetes or worsening of diabetes, High blood
sugar, Excessive drinking of water
• Weight loss, Loss of appetite resulting in
malnutrition and low body weight
• Increased cholesterol in your blood
• Elated mood (mania), Confusion, Decreased
sexual drive, Nervousness, Nightmares
• Tardive dyskinesia (twitching or jerking
movements that you cannot control in your
face, tongue, or other parts of your body). Tell
your doctor immediately if you experience
involuntary rhythmic movements of the tongue,
mouth and face. Withdrawal of Risperdal may
be needed,
• Sudden loss of blood supply to brain (stroke or
“mini” stroke)
• Unresponsive to stimuli, Loss of
consciousness, Low level of consciousness
• Convulsion (fits), Fainting
• A restless urge to move parts of your body,
Balance disorder, Abnormal coordination,
Dizziness upon standing, Disturbance in
attention, Problems with speech, Loss or
abnormal sense of taste, Reduced sensation of
skin to pain and touch, A sensation of tingling,
pricking, or numbness skin
• Oversensitivity of the eyes to light, Dry eye,
Increased tears, Redness of the eyes
• Sensation of spinning (vertigo), Ringing in the
ears, Ear pain
• Atrial fibrillation (an abnormal heart rhythm),
An interruption in conduction between the
upper and lower parts of the heart, Abnormal
electrical conduction of the heart, Prolongation
of the QT interval from your heart, Slow heart
rate, Abnormal electrical tracing of the heart
(electrocardiogram or ECG), A fluttering or
pounding feeling in your chest (palpitations)

• Low blood pressure, Low blood pressure upon
standing (consequently, some people taking
taking Risperdal may feel faint, dizzy, or may
pass out when they stand up or sit up
suddenly, Flushing
• Pneumonia caused by inhaling food, Lung
congestion, Congestion of breathing passages,
Crackly lung sounds, Wheezing, Voice
disorder, Breathing passage disorder
• Stomach or intestinal infection, Stool
incontinence, Very hard stool, Difficulty
swallowing, Excessive passing of gas or win
• Hives (or “nettle rash”), Itching, Hair loss,
Thickening of skin, Eczema, Dry skin, Skin
discoloration, Acne, Flaky, itchy scalp or skin,
Skin disorder, Skin lesion
• An increase of CPK (creatine phosphokinase)
in your blood, an enzyme which is sometimes
released with muscle breakdown
• Abnormal posture, Joint stiffness, Joint
swelling, Muscle weakness, Neck pain
• Frequent passing of urine, Inability to pass
urine, Pain when passing urine
• Erectile dysfunction, Ejaculation disorder
• Loss of menstrual periods, Missed menstrual
periods or other problems with your cycle
(females),
• Development of breasts in men, Leakage of
milk from the breasts, Sexual dysfunction,
Breast pain, Breast discomfort, Vaginal
discharge
• Swelling of the face, mouth, eyes, or lips
• Chills, An increase in body temperature
• A change in the way you walk
• Feeling thirsty, Feeling unwell, Chest
discomfort, Feeling “out of sorts”, Discomfort
• Increased liver transaminases in your blood,
Increased GGT (a liver enzyme called
gammaglutamyltransferase) in your blood,
Increased liver enzymes in your blood
• Procedural pain.
Rare (affects 1 to 10 users in 10,000):
• Infection
• Inappropriate secretion of a hormone that
controls urine volume
• Sugar in the urine, Low blood sugar, High blood
triglycerides (a fat)
• Lack of emotion, Inability to reach orgasm
• Neuroleptic malignant syndrome (confusion,
reduced or loss of consciousness, high fever,
and severe muscle stiffness)
• Blood vessel problems in the brain
• Coma due to uncontrolled diabetes
• Shaking of the head
• Glaucoma (increased pressure within the
eyeball), Problems with movement of your
eyes, Eye rolling, Eyelid margin crusting
• Eye problems during cataract surgery. During
cataract surgery, a condition called
intraoperative floppy iris syndrome (IFIS) can
happen if you take or have taken Risperdal. If
you need to have cataract surgery, be sure to
tell your eye doctor if you take or have taken
this medicine.
• Dangerously low numbers of a certain type of
white blood cell needed to fight infection in your
blood,
• Severe allergic reaction characterised by fever,
swollen mouth, face, lip or tongue, shortness of
breath, itching, skin rash and sometimes drop
in blood pressure
• Dangerously excessive intake of water
• Irregular heart beat
• Blood clot in the legs, Blood clot in the lungs
• Trouble breathing during sleep (sleep apnea),
Fast, shallow breathing
• Inflammation of the pancreas, A blockage in the
bowels
• Swollen tongue, Chapped lips, Rash on skin
related to drug
• Dandruff
• Breakdown of muscle fibers and pain in
muscles (rhabdomyolysis)
• A delay in menstrual periods, Enlargement of
the glands in your breasts, Breast enlargement,
Discharge from the breasts
• Increased insulin (a hormone that controls
blood sugar levels) in your blood
• Priapism (a prolonged penile erection that may
require surgical treatment)
• Hardening of the skin
• Decreased body temperature, A decrease in
body temperature, Coldness in arms and legs
• Symptoms of drug withdrawal
• Yellowing of the skin and the eyes (jaundice).
Very rare (affects less than 1 user in 10,000):
• Life threatening complications of uncontrolled
diabetes.
• Serious allergic reaction with swelling that may
involve the throat and lead to difficulty
breathing.
• Lack of bowel muscle movement that causes
blockage.
The following side effect has been seen with the
use of another medicine called paliperidone that
is very similar to risperidone, so these can also
be expected with Risperdal: Rapid heartbeat
upon standing.

Additional side effects in children and
adolescents
In general, side effects in children are expected
to be similar to those in adults.
The following side effects were reported more
often in children and adolescents (5 to 17 years)
than in adults: feeling sleepy, or less alert,
fatigue (tiredness), headache, increased
appetite, vomiting, common cold symptoms,
nasal congestion, abdominal pain, dizziness,
cough, fever, tremor (shaking), diarrhoea, and
incontinence (lack of control) of urine.

Reporting of side effects
If you get any side effects, talk to your doctor,
pharmacist or nurse. This includes any possible
side effects not listed in this leaflet. You can also
report side effects directly via the Yellow Card
Scheme at: www.mhra.gov.uk/yellowcard.
By reporting side effects, you can help provide
more information on the safety of this medicine.

5 How to store Risperdal
KEEP OUT OF THE SIGHT AND REACH OF
CHILDREN.
Do not store the tablets above 30°C.
Do not use the tablets after the expiry date
printed on the packaging.
Always return any left-over medicine to your
pharmacist. Only keep it if your doctor tells you
to.

If the tablets become discoloured or show signs
of deterioration, you should seek the advice of
your pharmacist
Medicines should not be disposed of via
wastewater or household waste. These
measures will help protect the environment.
Return any leftover Risperdal tablets to your
pharmacist. Only keep it if your doctor tells you
to.

6 Contents of the pack and other information
What Risperdal contains
The active substance
Each film-coated tablet also contains several
inactive ingredients, which allow it to be made.
These are: lactose, maize starch,
microcrystalline cellulose, hypromellose,
magnesium stearate, colloidal anhydrous silica,
sodium laurilsulfate and propylene glycol.
The 2mg tablets also contain: sunset yellow
(E110) aluminium lake, titanium dioxide (E171)
and talc
Each white, oblong, film-coated, half-scored
Risperdal 1mg tablet marked ‘RIS/1’ on one side
and plain on the other side contains 1mg of the
active ingredient risperidone.
Each pale orange, oblong, film-coated,
half-scored Risperdal 2mg tablet marked ‘RIS/2’
on one side and plain on the other side contains
2mg of the active ingredient risperidone.
Risperdal 1mg Tablets are available in pack size
of 20 tablets.
Risperdal 2mg Tablets are available in pack size
of 60 tablets.

Manufactured by:
Janssen-Cilag, S.P.A, Via C. Janssen, Borgo
San Michele, 04010, Latina, Italy (1mg, 2mg)
Janssen Pharmaceutica N.V., Turnhoutseweg,
30, 2340, Beerse, Belgium, (1mg, 2mg)
Lusomedicamenta – Sociedade Tecnica
Farmaceutica S.A, Estrada Consiglieri Pedroso,
69 B-Queluz de Baixo, 2730-055, Barcarena,
Portugal (1mg)
Procured from within the EU and repackaged
by the Product Licence holder:
B&S Healthcare, Unit 4, Bradfield Road, Ruislip,
Middlesex, HA4 0NU.
®

Risperdal 1mg tablets– PL No: 18799/1103
®
Risperdal 2mg tablets– PL No: 18799/1104
POM
Leaflet date: 12.09.2014
Risperdal is a trademark of JANSSEN- CILAG
Ltd.

 
 

PACKAGE LEAFLET: INFORMATION FOR THE USER

RISPERIDONE 1mg TABLETS
RISPERIDONE 2mg TABLETS
Read all of this leaflet carefully before you
start taking this medicine because it contains
important information for you.
• Keep this leaflet. You may need to read it
again.
• If you have any further questions, ask your
doctor or pharmacist.
• This medicine has been prescribed for you
only. Do not pass it on to others. It may harm
them, even if their signs of illness are the same
as yours.
• If you get any side effects, talk to your doctor
or pharmacist. This includes any possible side
effects not listed in this leaflet. See section 4.
The name of your medicine is Risperidone 1mg
Tablets and Risperidone 2mg Tablets but it will
be referred as Risperidone throughout this
leaflet.

Please note that this leaflet also contains
information about other strengths such as
Risperidone 0.5mg, 3mg, 4mg and 6mg Tablets
and Risperidone Quicklet 0.5 mg, 1mg, 2mg, 3mg
and 4mg Orodispersible tablets.
What is in this leaflet:
1

What Risperidone is and what it is used for

2

What you need to know before you take
Risperidone
How to take Risperidone

3
4

Possible side effects

5

How to store Risperidone

6

Contents of the pack and other information

1 What Risperidone is and what it is used for
Risperidone belongs to a group of medicines
called
‘anti-psychotics’.
Risperidone is used to treat the following:
• Schizophrenia, where you may see, hear or
feel things that are not there, believe things
that are not true or feel unusually suspicious,
or confused
• Mania, where you may feel very excited,
elated, agitated, enthusiastic or hyperactive
Mania occurs in an illness called “bipolar
disorder”

• Short-term treatment (up to 6 weeks) of longterm aggression in people with Alzheimer’s
dementia, who harm themselves or others.
Alternative (non-drug) treatments should have
been used previously.
• Short-term treatment (up to 6 weeks) of longterm, aggression in intellectually disabled
children (at least 5 years of age) and
adolescents with conduct disorder.
Risperidone can help alleviate the symptoms of
your disease and stop your symptoms from
coming back.

2 What you need to know before you take Risperidone
Do not take Risperidone if:
• You are allergic (hypersensitive) to risperidone
or any of the other ingredients of this medicine
(listed in section 6).
If you are not sure if the above applies to you,
talk to your doctor or pharmacist before using
Risperidone.
Warnings and precautions
Talk to your doctor or pharmacist before
taking Risperidone if:
• You have a heart problem. Examples include
an irregular heart rhythm or if you are prone to
low blood pressure or if you are using
medicines for your blood pressure. Risperidone
may cause low blood pressure. Your dose may
need to be adjusted
• You know of any factors which would favour
you having a stroke, such as high blood
pressure, cardiovascular disorder or blood
vessel problems in the brain
• You have ever experienced involuntary
movements of the tongue, mouth and face
• You have ever had a condition whose
symptoms include high temperature, muscle
stiffness, sweating or a lowered level of
consciousness (also known as Neuroleptic
Malignant Syndrome)
• You have Parkinson’s disease or dementia
• You know that you have had low levels of white
blood cells in the past (which may or may not
have been caused by other medicines)
• You are diabetic
• You have epilepsy
• You are a man and you have ever had a
prolonged or painful erection
• You have problems controlling your body
temperature or overheating
• You have kidney problems
• You have liver problems
• You have an abnormally high level of the
hormone prolactin in your blood or if you have
a possible prolactin-dependent tumour.
• You or someone else in your family has a
history of blood clots, as antipsychotics have
been associated with formation of blood clots.
If you are not sure if any of the above applies to
you, talk to your doctor or pharmacist before
using Risperidone.
As dangerously low numbers of a certain type of
white blood cell needed to fight infection in your
blood has been seen very rarely with patients
taking Risperidone, your doctor may check your
white blood cell counts.
Risperidone may cause you to gain weight.
Significant weight gain may adversely affect your
health. Your doctor should regularly measure
your body weight.
As diabetes mellitus or worsening of pre-existing
diabetes mellitus have been seen with patients
taking Risperidone, your doctor should check for
signs of high blood sugar. In patients with preexisting diabetes mellitus blood glucose should
be monitored regularly.
During an operation on the eye for cloudiness of
the lens (cataract), the pupil (the black circle in
the middle of your eye) may not increase in size
as needed. Also, the iris (the coloured part of the
eye) may become floppy during surgery and that
may lead to eye damage. If you are planning to
have an operation on your eye, make sure you
tell your eye doctor that you are taking this
medicine
Elderly people with dementia
In elderly patients with dementia, there is an
increased risk of stroke. You should not take
risperidone if you have dementia caused by
stroke.
During treatment with risperidone you should
frequently see your doctor.
Medical treatment should be sought straight
away if you or your care-giver notice a sudden

change in your mental state or sudden weakness
or numbness of your face, arms or legs,
especially on one side, or slurred speech, even
for a short period of time. These may be signs of
a stroke.
Children and adolescents
Before treatment is started for conduct disorder,
other causes of aggressive behaviour should
have been ruled out.
If during treatment with risperidone tiredness
occurs, a change in the time of administration
might improve attention difficulties.
Before treatment is started your, or your child’s
body weight may be measured and it may be
regularly monitored during treatment.
Other medicines and Risperidone
Tell your doctor or pharmacist if you are taking,
have recently taken or might take any other
medicines.
It is especially important to talk to your
doctor or pharmacist if you are taking any of
the following:
• Medicines that work on your brain such as to
help you calm down (benzodiazepines) or
some medicines for pain (opiates), medicines
for allergy (some antihistamines), as
risperidone may increase the sedative effect of
all of these
• Medicines that may change the electrical
activity of your heart, such as medicines for
malaria, heart rhythm problems, allergies (antihistamines), some antidepressants or other
medicines for mental problems
• Medicines that cause a slow heart beat
• Medicines that cause low blood potassium
(such as certain diuretics)
• Medicines to treat raised blood pressure.
Risperidone can lower blood pressure
• Medicines for Parkinson's disease (such as
levodopa)
• Water tablets (diuretics) used for heart
problems or swelling of parts of your body due
to a build up of too much fluid (such as
furosemide or chlorothiazide). Risperidone
taken by itself or with furosemide, may have an
increased risk of stroke or death in elderly
people with dementia.
The following medicines may reduce the
effect of risperidone
• Rifampicin (a medicine for treating some
infections)
• Carbamazepine, phenytoin (medicines for
epilepsy)
• Phenobarbital
If you start or stop taking such medicines you
may need a different dose of risperidone.
The following medicines may increase the
effect of risperidone
• Quinidine (used for certain types of heart
disease)
• Antidepressants such as paroxetine, fluoxetine,
tricyclic antidepressants
• Medicines known as beta blockers (used to
treat high blood pressure)
• Phenothiazines (such as medicines used to
treat psychosis or to calm down)
• Cimetidine, ranitidine (blockers of the acidity of
stomach)
If you start or stop taking such medicines you
may need a different dose of risperidone.
If you are not sure if any of the above applies to
you, talk to your doctor or pharmacist before
using Risperidone.
Risperidone with food, drink and alcohol
You can take this medicine with or without food.
You should avoid drinking alcohol when taking
Risperidone.

Pregnancy, breast-feeding and fertility
• If you are pregnant or breast-feeding, think you
may be pregnant or are planning to have a baby,
ask your doctor or pharmacist for advice before
taking this medicine. Your doctor will decide if
you can take it
• The following symptoms may occur in newborn
babies, of mothers that have used Risperidone in
the last trimester (last three months of their
pregnancy): shaking, muscle stiffness and/or
weakness, sleepiness, agitation, breathing
problems, and difficulty in feeding. If your baby
develops any of these symptoms you may need
to contact your doctor.
• Risperidone can raise your levels of a hormone
called “prolactin” that may impact fertility (see
Possible side effects).

Driving and using machines
Dizziness, tiredness, and vision problems may
occur during treatment with Risperidone. Do not
drive or use any tools or machines without talking
to your doctor first.
Risperidone contains lactose or aspartame
The film-coated tablets contain lactose, a type of
sugar. If you have been told by your doctor that you
have an intolerance to some sugars, contact your
doctor before taking this medicinal product.
The 2mg and 6mg film-coated tablets contain
sunset yellow (E110) that may cause allergic
reactions.
The orodispersible tablets contain aspartame, a
source of phenylalanine which may be harmful for
people with phenylketonuria.

3 How to take Risperidone
Always take this medicine exactly as your doctor
has told you. Check with your doctor or
pharmacist if you are not sure.
The recommended dose is as follows:
For the treatment of schizophrenia
Adults
• The usual starting dose is 2mg per day, this
may be increased to 4mg per day on the
second day
• Your dose may then be adjusted by your
doctor depending on how you respond to the
treatment
• Most people feel better with daily doses of 4 to
6mg.
• This total daily dose can be divided into either
one or two doses a day. Your doctor will tell
you which is the best for you.
Elderly people
• Your starting dose will normally be 0.5mg twice
a day
• Your dose may then be gradually increased by
your doctor to 1mg to 2mg twice a day
• Your doctor will tell you which is the best for
you.
For the treatment of mania
Adults
• Your starting dose will usually be 2mg once a
day
• Your dose may then be gradually adjusted by
your doctor depending on how you respond to
the treatment
• Most people feel better with doses of 1 to 6mg
once a day.
Elderly people
• Your starting dose will usually be 0.5mg twice
a day
• Your dose may then be gradually adjusted by
your doctor to 1mg to 2mg twice a day
depending on how much you respond to the
treatment.
For the treatment of long-standing
aggression in people with Alzheimer’s
dementia
Adults (including elderly people)
• Your starting dose will normally be 0.25mg
twice a day
• Your dose may then be gradually adjusted by
your doctor depending on how you respond to
the treatment
• Most people feel better with 0.5mg twice a day.
Some patients may need 1mg twice a day
• Treatment duration in patients with Alzheimer’s
dementia should be not more than 6 weeks.
Use in children and adolescents
• Children and adolescents under 18 years old
should not be treated with Risperidone for
schizophrenia or mania.
For the treatment of conduct disorder
The dose will depend on your child’s weight:
For children who weigh less than 50kg
• The starting dose will normally be 0.25mg once
a day
• The dose may be increased every other day in
steps of 0.25mg per day.
• The usual maintenance dose is 0.25mg to
0.75mg once a day.

For children who weigh 50kg or more
• The starting dose will normally be 0.5mg once
a day
• The dose may be increased every other day in
steps of 0.5mg per day.
• The usual maintenance dose is 0.5mg to 1.5mg
once a day.
Treatment duration in patients with conduct
disorder should be not more than 6 weeks.
Children under 5 years old should not be treated
with Risperidone for conduct disorder.
People with kidney or liver problems
Regardless of the disease to be treated, all
starting doses and following doses of risperidone
should be halved. Dose increases should be
slower in these patients.
Risperidone should be used with caution in this
patient group.
Risperidone film-coated tablets
• You should swallow your tablet with a drink of
water
• The score line is only there to help you break
the tablet if you have difficulty swallowing it
whole.
Risperidone Quicklet orodispersible tablets
Only remove a tablet from the blister when it is
time to take your medicine.
• Peel open a blister to expose the tablet
• Do not push the tablet through the foil because
it may break
• Remove the tablet from the blister with dry
hands
• Place the tablet on your tongue straight away
• The tablet will begin disintegrating within
seconds
• It can then be swallowed with or without water.
If you take more Risperidone than you should
• See a doctor right away. Take the medicine
pack with you
• In case of overdose you may feel sleepy or
tired, or have abnormal body movements,
problems standing and walking, feel dizzy due
to low blood pressure, or have abnormal heart
beats or fits.
If you forget to take Risperidone
• If you forget to take a dose, take it as soon as
you remember it. However, if it is almost time
for your next dose, skip the missed dose and
continue as usual. If you miss two or more
doses, contact your doctor
• Do not take a double dose (two doses at the
same time) to make up for a forgotten dose
If you stop taking Risperidone
You should not stop taking this medicine unless
told to do so by your doctor. Your symptoms may
return. If your doctor decides to stop this
medicine, your dose may be decreased gradually
over a few days.
If you have any further questions on the use of
this medicine, ask your doctor or pharmacist.

4 Possible side effects
Like all medicines, this medicine can cause side
effects, although not everybody gets them.
Tell your doctor immediately if you:
• Experience blood clots in the veins, especially
in the legs (symptoms include swelling, pain,
and redness in the leg), which may travel
through blood vessels to the lungs causing
chest pain and difficulty breathing. If you notice
any if these symptoms seek medical advice
immediately
• Have dementia and experience a sudden
change in your mental state or sudden
weakness or numbness of your face, arms or
legs, especially on one side, or slurred speech,
even for a short period of time. These may be
signs of a stroke
• Experience fever, muscle stiffness, sweating or
a lowered level of consciousness (a disorder
called “Neuroleptic Malignant Syndrome”).
Immediate medical treatment may be needed

• Are a man and experience prolonged or painful
erection. This is called priapism. Immediate
medical treatment may be needed
• Experience involuntary rhythmic movements of
the tongue, mouth and face. Withdrawal of
risperidone may be needed
• Experience severe allergic reaction
characterised by fever, swollen mouth, face, lip
or tongue, shortness of breath, itching, skin
rash or drop in blood pressure.

4 Possible side effects (continued)
The following side effects may happen:
Very Common (affects more than 1 user in
10):
• Difficulty falling or staying asleep
• Parkinsonism: This condition may include:
slow or impaired movement, sensation of
stiffness or tightness of the muscles (making
your movements jerky), and sometimes even a
sensation of movement “freezing up” and then
restarting. Other signs of parkinsonism include
a slow shuffling walk, a tremor while at rest,
increased saliva and/or drooling, and a loss of
expression on the face.
• Feeling sleepy, or less alert
• Headache
Common (affects 1 to 10 users in 100):
• Pneumonia, Infection of the chest (bronchitis),
Common cold symptoms, Sinus infection
Urinary tract infection Ear infection, Feeling like
you have the flu
• Risperidone can raise your levels of a hormone
called “prolactin” found on a blood test (which
may or may not cause symptoms). When
symptoms of high prolactin occur, they may
include in men breast swelling, difficulty in
getting or maintaining erections, or other
sexual dysfunction. In women they may include
breast discomfort, leakage of milk from the
breasts, missed menstrual periods, or other
problems with your cycle.
• Weight gain, Increased appetite, Decreased
appetite
• Sleep disorder, Irritability, Depression, Anxiety,
Restlessness
• Dystonia: This is a condition involving slow or
sustained involuntary contraction of muscles.
While it can involve any part of the body (and
may result in abnormal posture), dystonia often
involves muscles of the face, including
abnormal movements of the eyes, mouth,
tongue or jaw.
• Dizziness
• Dyskinesia: This is a condition involving
involuntary muscle movements, and can
include repetitive, spastic or writhing
movements, or twitching.
• Tremor (shaking)
• Blurry vision, Eye infection or “pink eye”
• Rapid heart rate, High blood pressure,
Shortness of breath
• Sore throat, Cough, Nosebleeds, Stuffy nose
• Abdominal pain, Abdominal discomfort,
Vomiting, Nausea, Constipation, Diarrhoea,
Indigestion, Dry mouth, Toothache
• Rash, Skin redness
• Muscle spasms, Bone or muscle ache, Back
pain, Joint pain
• Incontinence (lack of control) of urine
• Swelling of the body, arms or legs, Fever,
Chest pain, Weakness, Fatigue (tiredness),
Pain
• Fall.
Uncommon (affects 1 to 10 users in 1000):
• Infection of the breathing passages, Bladder
infection, ‘Eye infection, Tonsillitis, Fungal
infection of the nails, Infection of the skin, An
infection confined to a single area of skin or
part of the body, Viral infection, Skin
inflammation caused by mites
• Decrease in the type of white blood cells that
help to protect you against infection, White
blood cell count decreased Decrease in
platelets (blood cells that help you stop
bleeding), Anemia, Decrease in red blood cells,
Increase in eosinophils (a type of white blood
cell) in your blood
• Allergic reaction
• Diabetes or worsening of diabetes, High blood
sugar, Excessive drinking of water
• Weight loss, Loss of appetite resulting in
malnutrition and low body weight
• Increased cholesterol in your blood
• Elated mood (mania), Confusion, Decreased
sexual drive, Nervousness, Nightmares
• Tardive dyskinesia (twitching or jerking
movements that you cannot control in your
face, tongue, or other parts of your body). Tell
your doctor immediately if you experience
involuntary rhythmic movements of the tongue,
mouth and face. Withdrawal of Risperidone
may be needed,
• Sudden loss of blood supply to brain (stroke or
“mini” stroke)
• Unresponsive to stimuli, Loss of
consciousness, Low level of consciousness
• Convulsion (fits), Fainting
• A restless urge to move parts of your body,
Balance disorder, Abnormal coordination,
Dizziness upon standing, Disturbance in
attention, Problems with speech, Loss or
abnormal sense of taste, Reduced sensation of
skin to pain and touch, A sensation of tingling,
pricking, or numbness skin
• Oversensitivity of the eyes to light, Dry eye,
Increased tears, Redness of the eyes
• Sensation of spinning (vertigo), Ringing in the
ears, Ear pain
• Atrial fibrillation (an abnormal heart rhythm),
An interruption in conduction between the
upper and lower parts of the heart, Abnormal
electrical conduction of the heart, Prolongation
of the QT interval from your heart, Slow heart
rate, Abnormal electrical tracing of the heart
(electrocardiogram or ECG), A fluttering or
pounding feeling in your chest (palpitations)

• Low blood pressure, Low blood pressure upon
standing (consequently, some people taking
taking Risperidone may feel faint, dizzy, or may
pass out when they stand up or sit up
suddenly, Flushing
• Pneumonia caused by inhaling food, Lung
congestion, Congestion of breathing passages,
Crackly lung sounds, Wheezing, Voice
disorder, Breathing passage disorder
• Stomach or intestinal infection, Stool
incontinence, Very hard stool, Difficulty
swallowing, Excessive passing of gas or win
• Hives (or “nettle rash”), Itching, Hair loss,
Thickening of skin, Eczema, Dry skin, Skin
discoloration, Acne, Flaky, itchy scalp or skin,
Skin disorder, Skin lesion
• An increase of CPK (creatine phosphokinase)
in your blood, an enzyme which is sometimes
released with muscle breakdown
• Abnormal posture, Joint stiffness, Joint
swelling, Muscle weakness, Neck pain
• Frequent passing of urine, Inability to pass
urine, Pain when passing urine
• Erectile dysfunction, Ejaculation disorder
• Loss of menstrual periods, Missed menstrual
periods or other problems with your cycle
(females),
• Development of breasts in men, Leakage of
milk from the breasts, Sexual dysfunction,
Breast pain, Breast discomfort, Vaginal
discharge
• Swelling of the face, mouth, eyes, or lips
• Chills, An increase in body temperature
• A change in the way you walk
• Feeling thirsty, Feeling unwell, Chest
discomfort, Feeling “out of sorts”, Discomfort
• Increased liver transaminases in your blood,
Increased GGT (a liver enzyme called
gammaglutamyltransferase) in your blood,
Increased liver enzymes in your blood
• Procedural pain.
Rare (affects 1 to 10 users in 10,000):
• Infection
• Inappropriate secretion of a hormone that
controls urine volume
• Sugar in the urine, Low blood sugar, High blood
triglycerides (a fat)
• Lack of emotion, Inability to reach orgasm
• Neuroleptic malignant syndrome (confusion,
reduced or loss of consciousness, high fever,
and severe muscle stiffness)
• Blood vessel problems in the brain
• Coma due to uncontrolled diabetes
• Shaking of the head
• Glaucoma (increased pressure within the
eyeball), Problems with movement of your
eyes, Eye rolling, Eyelid margin crusting
• Eye problems during cataract surgery. During
cataract surgery, a condition called
intraoperative floppy iris syndrome (IFIS) can
happen if you take or have taken Risperidone.
If you need to have cataract surgery, be sure to
tell your eye doctor if you take or have taken
this medicine.
• Dangerously low numbers of a certain type of
white blood cell needed to fight infection in your
blood,
• Severe allergic reaction characterised by fever,
swollen mouth, face, lip or tongue, shortness of
breath, itching, skin rash and sometimes drop
in blood pressure
• Dangerously excessive intake of water
• Irregular heart beat
• Blood clot in the legs, Blood clot in the lungs
• Trouble breathing during sleep (sleep apnea),
Fast, shallow breathing
• Inflammation of the pancreas, A blockage in the
bowels
• Swollen tongue, Chapped lips, Rash on skin
related to drug
• Dandruff
• Breakdown of muscle fibers and pain in
muscles (rhabdomyolysis)
• A delay in menstrual periods, Enlargement of
the glands in your breasts, Breast enlargement,
Discharge from the breasts
• Increased insulin (a hormone that controls
blood sugar levels) in your blood
• Priapism (a prolonged penile erection that may
require surgical treatment)
• Hardening of the skin
• Decreased body temperature, A decrease in
body temperature, Coldness in arms and legs
• Symptoms of drug withdrawal
• Yellowing of the skin and the eyes (jaundice).
Very rare (affects less than 1 user in 10,000):
• Life threatening complications of uncontrolled
diabetes.
• Serious allergic reaction with swelling that may
involve the throat and lead to difficulty
breathing.
• Lack of bowel muscle movement that causes
blockage.
The following side effect has been seen with the
use of another medicine called paliperidone that
is very similar to risperidone, so these can also
be expected with Risperidone: Rapid heartbeat
upon standing.

Additional side effects in children and
adolescents
In general, side effects in children are expected
to be similar to those in adults.
The following side effects were reported more
often in children and adolescents (5 to 17 years)
than in adults: feeling sleepy, or less alert,
fatigue (tiredness), headache, increased
appetite, vomiting, common cold symptoms,
nasal congestion, abdominal pain, dizziness,
cough, fever, tremor (shaking), diarrhoea, and
incontinence (lack of control) of urine.

Reporting of side effects
If you get any side effects, talk to your doctor,
pharmacist or nurse. This includes any possible
side effects not listed in this leaflet. You can also
report side effects directly via the Yellow Card
Scheme at: www.mhra.gov.uk/yellowcard.
By reporting side effects, you can help provide
more information on the safety of this medicine.

5 How to store Risperidone
KEEP OUT OF THE SIGHT AND REACH OF
CHILDREN.
Do not store the tablets above 30°C.
Do not use the tablets after the expiry date
printed on the packaging.
Always return any left-over medicine to your
pharmacist. Only keep it if your doctor tells you
to.

If the tablets become discoloured or show signs
of deterioration, you should seek the advice of
your pharmacist
Medicines should not be disposed of via
wastewater or household waste. These
measures will help protect the environment.
Return any leftover Risperidone tablets to your
pharmacist. Only keep it if your doctor tells you
to.

6 Contents of the pack and other information
What Risperidone contains
The active substance
Each film-coated tablet also contains several
inactive ingredients, which allow it to be made.
These are: lactose, maize starch,
microcrystalline cellulose, hypromellose,
magnesium stearate, colloidal anhydrous silica,
sodium laurilsulfate and propylene glycol.
The 2mg tablets also contain: sunset yellow
(E110) aluminium lake, titanium dioxide (E171)
and talc
Each white, oblong, film-coated, half-scored
Risperidone 1mg tablet marked ‘RIS/1’ on one
side and plain on the other side contains 1mg of
the active ingredient risperidone.
Each pale orange, oblong, film-coated,
half-scored Risperidone 2mg tablet marked
‘RIS/2’ on one side and plain on the other side
contains 2mg of the active ingredient risperidone.
Risperidone 1mg Tablets are available in pack
size of 20 tablets.
Risperidone 2mg Tablets are available in pack
size of 60 tablets.

 

Manufactured by:
Janssen-Cilag, S.P.A, Via C. Janssen, Borgo
San Michele, 04010, Latina, Italy (1mg, 2mg)
Janssen Pharmaceutica N.V., Turnhoutseweg,
30, 2340, Beerse, Belgium, (1mg, 2mg)
Lusomedicamenta – Sociedade Tecnica
Farmaceutica S.A, Estrada Consiglieri Pedroso,
69 B-Queluz de Baixo, 2730-055, Barcarena,
Portugal (1mg)
Procured from within the EU and repackaged
by the Product Licence holder:
B&S Healthcare, Unit 4, Bradfield Road, Ruislip,
Middlesex, HA4 0NU.
Risperidone 1mg tablets– PL No: 18799/1103
Risperidone 2mg tablets– PL No: 18799/1104
POM
Leaflet date: 12.09.2014

 

Expand view ⇕

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

Hide
(web3)